EC 184.108.40.206 Enzyme
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
5-methyl-1-naphthoate,NADPH:oxygen oxidoreductase (3-hydroxylating)
5-methyl-1-naphthoate + NADPH + H+ + O2 = 3-hydroxy-5-methyl-1-naphthoate + NADP+ + H2O [RN:
The enzyme from the bacterium Streptomyces sahachiroi is involved in the biosynthesis of 3-methoxy-5-methyl-1-naphthoate, a component of of the the antitumor antibiotic azinomycin B.
EC 220.127.116.11 created 2014
Ding W, Deng W, Tang M, Zhang Q, Tang G, Bi Y, Liu W
Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the antitumor antibiotic azinomycin B.
Mol Biosyst 6:1071-81 (2010)
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