KEGG ENZYME: 1.14.13.189

ENZYME: 1.14.13.189

Entry

EC 1.14.13.189 Enzyme

Name

5-methyl-1-naphthoate 3-hydroxylase;
AziB1

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

5-methyl-1-naphthoate,NADPH:oxygen oxidoreductase (3-hydroxylating)

Reaction(IUBMB)

5-methyl-1-naphthoate + NADPH + H+ + O2 = 3-hydroxy-5-methyl-1-naphthoate + NADP+ + H2O [RN:R10725]

Reaction(KEGG)

R10725

Substrate

5-methyl-1-naphthoate [CPD:C20803];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

3-hydroxy-5-methyl-1-naphthoate [CPD:C20805];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Comment

The enzyme from the bacterium Streptomyces sahachiroi is involved in the biosynthesis of 3-methoxy-5-methyl-1-naphthoate, a component of of the the antitumor antibiotic azinomycin B.

History

EC 1.14.13.189 created 2014

Orthology

K21376

5-methyl-1-naphthoate 3-hydroxylase

Reference

1 [PMID:20485749]

Authors

Ding W, Deng W, Tang M, Zhang Q, Tang G, Bi Y, Liu W

Title

Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the antitumor antibiotic azinomycin B.

Journal