| Entry |
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| Name |
albendazole monooxygenase;
albendazole oxidase (misleading);
albendazole sulfoxidase (ambiguous);
FMO3 (gene name);
albendazole monooxygenase (flavin-containing)
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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| Sysname |
albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)
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| Reaction(IUBMB) |
albendazole + NADPH + H+ + O2 = albendazole S-oxide + NADP+ + H2O [RN: R03712]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A microsomal flavin-containing monooxygenase. A similar conversion is also carried out by some microsomal cytochrome P-450 enzymes [EC 1.14.14.73, albendazole monooxygenase (sulfoxide-forming)]. It is estimated that cytochrome P-450s are responsible for 70% of the activity.
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| History |
EC 1.14.13.32 created 1989, modified 2018
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| Orthology |
| K17689 | cytochrome P450 family 3 subfamily A4 |
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| Genes |
» show all
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| Reference |
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| Authors |
Fargetton X, Galtier P, Delatour P. |
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| Title |
Sulfoxidation of albendazole by a cytochrome P450-independent monooxygenase from rat liver microsomes. |
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| Journal |
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| Reference |
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| Authors |
Moroni P, Buronfosse T, Longin-Sauvageon C, Delatour P, Benoit E |
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| Title |
Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes. |
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| Journal |
Drug Metab Dispos 23:160-5 (1995) |
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| Reference |
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| Authors |
Rawden HC, Kokwaro GO, Ward SA, Edwards G. |
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| Title |
Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes. |
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| Journal |
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| Other DBs |
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| LinkDB |
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