Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)

4-hydroxybenzoate + NAD(P)H + 2 H+ + O2 = hydroquinone + NAD(P)+ + H2O + CO2 [RN:R01297 R01299]

R01297 R01299;
(other) R01629 R01630

4-hydroxybenzoate [CPD:C00156];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]

Requires FAD. The enzyme from Candida parapsilosis is specific for 4-hydroxybenzoate derivatives and prefers NADH to NADPH as electron donor.

EC 1.14.13.64 created 1999

1  [PMID:7926672]

van Berkel WJ, Eppink MH, Middelhoven WJ, Vervoort J, Rietjens IM.

Catabolism of 4-hydroxybenzoate in Candida parapsilosis proceeds through initial oxidative decarboxylation by a FAD-dependent 4-hydroxybenzoate 1-hydroxylase.

FEMS Microbiol Lett 121:207-15 (1994)
DOI:10.1111/j.1574-6968.1994.tb07100.x