Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy

phenylacetone,NADPH:oxygen oxidoreductase

phenylacetone + NADPH + H+ + O2 = benzyl acetate + NADP+ + H2O [RN:R07201]

R07201
Reaction

phenylacetone [CPD:C15512];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]

A flavoprotein (FAD). NADH cannot replace NADPH as coenzyme. In addition to phenylacetone, which is the best substrate found to date, this Baeyer-Villiger monooxygenase can oxidize other aromatic ketones [1-(4-hydroxyphenyl)propan-2-one, 1-(4-hydroxyphenyl)propan-2-one and 3-phenylbutan-2-one], some alipatic ketones (e.g. dodecan-2-one) and sulfides (e.g. 1-methyl-4-(methylsulfanyl)benzene).

EC 1.14.13.92 created 2005

1  [PMID:15328411]

Malito E, Alfieri A, Fraaije MW, Mattevi A.

Crystal structure of a Baeyer-Villiger monooxygenase.

Proc Natl Acad Sci U S A 101:13157-62 (2004)
DOI:10.1073/pnas.0404538101

[tfu:Tfu_1490]

2  [PMID:15599520]

Fraaije MW, Wu J, Heuts DP, van Hellemond EW, Spelberg JH, Janssen DB

Discovery of a thermostable Baeyer-Villiger monooxygenase by genome mining.

Appl Microbiol Biotechnol 66:393-400 (2005)
DOI:10.1007/s00253-004-1749-5

[tfu:Tfu_1490]