KEGG   ENZYME: 1.14.14.128
Entry
EC 1.14.14.128              Enzyme                                 

Name
farnesoate epoxidase;
CYP15C1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
(2E,6E)-farnesoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
(2E,6E)-farnesoate + [reduced NADPH---hemoprotein reductase] + O2 = juvenile-hormone-III carboxylate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R10925]
Reaction(KEGG)
R10925
Substrate
(2E,6E)-farnesoate [CPD:C16502];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
juvenile-hormone-III carboxylate [CPD:C16504];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate (cf. EC 1.14.14.127, methyl farnesoate epoxidase) [1,2]. It is involved in the synthesis of juvenile hormone.
History
EC 1.14.14.128 created 2015 as EC 1.14.13.203, transferred 2018 to EC 1.14.14.128
Pathway
ec00981  Insect hormone biosynthesis
Orthology
K14937  methyl farnesoate epoxidase / farnesoate epoxidase
Genes
AGA: AgaP_AGAP005658
AAG: 5573424
AALB: 109400580 109404918
CQU: CpipJ_CPIJ014944
AME: 551179 551632
BIM: 100741407
BTER: 100642209
CCAL: 108622763 108626525 108628064
OBB: 114880426 114882699
SOC: 105193715 105201474
MPHA: 105834547
TCA: 658858(CYP15A1)
DPA: 109538052
ATD: 109600030
NVL: 108561482
BMOR: 100286798(P450)
BMAN: 114249593
PMAC: 106719118
PRAP: 110999807
HAW: 110370071
TNL: 113496128
PXY: 105393482
DNX: 107173974
BTAB: 109037742
CLEC: 106662678
ZNE: 110840507
 » show all
Reference
1  [PMID:22412378]
  Authors
Daimon T, Kozaki T, Niwa R, Kobayashi I, Furuta K, Namiki T, Uchino K, Banno Y, Katsuma S, Tamura T, Mita K, Sezutsu H, Nakayama M, Itoyama K, Shimada T, Shinoda T
  Title
Precocious metamorphosis in the juvenile hormone-deficient mutant of the silkworm, Bombyx mori.
  Journal
PLoS Genet 8:e1002486 (2012)
DOI:10.1371/journal.pgen.1002486
  Sequence
[bmor:100286798]
Reference
2  [PMID:23586995]
  Authors
Daimon T, Shinoda T
  Title
Function, diversity, and application of insect juvenile hormone epoxidases (CYP15).
  Journal
Biotechnol Appl Biochem 60:82-91 (2013)
DOI:10.1002/bab.1058
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.128
IUBMB Enzyme Nomenclature: 1.14.14.128
ExPASy - ENZYME nomenclature database: 1.14.14.128
BRENDA, the Enzyme Database: 1.14.14.128
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