KEGG   ENZYME: 1.14.14.17
Entry
EC 1.14.14.17               Enzyme                                 

Name
squalene monooxygenase;
squalene epoxidase;
squalene-2,3-epoxide cyclase;
squalene 2,3-oxidocyclase;
squalene hydroxylase;
squalene oxydocyclase;
squalene-2,3-epoxidase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
squalene,NADPH---hemoprotein:oxygen oxidoreductase (2,3-epoxidizing)
Reaction(IUBMB)
squalene + [reduced NADPH---hemoprotein reductase] + O2 = (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R02874]
Reaction(KEGG)
R02874
Substrate
squalene [CPD:C00751];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7, lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor is EC 1.6.2.4, NADPH---hemoprotein reductase [5,7].
History
EC 1.14.14.17 created 1961 as EC 1.99.1.13, transferred 1965 to EC 1.14.1.3, part transferred 1972 to EC 1.14.99.7, transferred 2011 to EC 1.14.13.132, transferred 2015 to EC 1.14.14.17
Pathway
ec00100  Steroid biosynthesis
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00511  squalene monooxygenase
Genes
HSA: 6713(SQLE)
PTR: 464383(SQLE)
PPS: 100976805(SQLE)
GGO: 101129462(SQLE)
PON: 100453462(SQLE)
NLE: 100585992(SQLE)
MCC: 706764(SQLE)
MCF: 102118907(SQLE)
CSAB: 103237411(SQLE)
RRO: 104662802(SQLE)
RBB: 108538084(SQLE)
CJC: 100410163(SQLE)
SBQ: 101054084(SQLE)
MMU: 20775(Sqle)
MCAL: 110310474(Sqle)
MPAH: 110334642(Sqle)
RNO: 29230(Sqle)
MUN: 110552435(Sqle)
CGE: 100764834(Sqle)
NGI: 103743909(Sqle)
HGL: 101709317(Sqle)
CCAN: 109688126(Sqle)
OCU: 100356021(SQLE)
TUP: 102473783(SQLE)
CFA: 608021(SQLE)
VVP: 112915974(SQLE)
AML: 100465589(SQLE)
UMR: 103661624(SQLE)
UAH: 113252737(SQLE)
ORO: 101386907(SQLE)
ELK: 111146730
FCA: 101086537(SQLE)
PTG: 102948681(SQLE)
PPAD: 109273158(SQLE)
AJU: 106986573(SQLE)
BTA: 526535(SQLE)
BOM: 102264644(SQLE)
BIU: 109568596(SQLE)
BBUB: 102411716(SQLE)
CHX: 102187506(SQLE)
OAS: 100125351(SQLE)
SSC: 100113409(SQLE)
CFR: 102518096(SQLE)
CDK: 105096439(SQLE)
BACU: 103015244(SQLE)
LVE: 103088551(SQLE)
OOR: 101275903(SQLE)
DLE: 111164434(SQLE)
PCAD: 102996556(SQLE)
ECB: 100067615(SQLE)
EPZ: 103555758(SQLE)
EAI: 106839365(SQLE)
MYB: 102239947(SQLE)
MYD: 102766276(SQLE)
MNA: 107539554(SQLE)
HAI: 109383232(SQLE)
DRO: 112315359(SQLE)
PALE: 102894920(SQLE)
RAY: 107521591(SQLE)
MJV: 108400205(SQLE)
LAV: 100664731(SQLE)
TMU: 101359006
MDO: 100032247(SQLE)
SHR: 100918180(SQLE)
PCW: 110193305(SQLE)
OAA: 100076751(SQLE)
GGA: 420335(SQLE)
MGP: 100546703(SQLE)
CJO: 107310534(SQLE)
NMEL: 110394194(SQLE)
APLA: 101802617(SQLE)
ACYG: 106038503(SQLE)
TGU: 100225604(SQLE)
LSR: 110476988(SQLE)
SCAN: 103814522(SQLE)
GFR: 102033103(SQLE)
FAB: 101806873(SQLE)
PHI: 102109574(SQLE)
PMAJ: 107200846(SQLE)
CCAE: 111925120(SQLE)
CCW: 104692651(SQLE)
ETL: 114065244(SQLE)
FPG: 101920264(SQLE)
FCH: 102054050(SQLE)
CLV: 102090054(SQLE)
EGZ: 104134437(SQLE)
NNI: 104017981(SQLE)
ACUN: 113477107(SQLE)
PADL: 103916372(SQLE)
AAM: 106496303(SQLE)
ASN: 102368291(SQLE)
AMJ: 102563308(SQLE)
PSS: 102444614(SQLE)
CMY: 102929627(SQLE)
CPIC: 101943545(SQLE)
ACS: 100557553(sqle)
PVT: 110080534(SQLE)
PBI: 103062700
PMUR: 107295853(SQLE)
PMUA: 114600258(SQLE)
GJA: 107118942(SQLE)
XLA: 108695454(sqle.S) 108719421(sqle.L)
XTR: 100491400(sqle)
NPR: 108789438(SQLE)
DRE: 565329(sqleb) 799528(sqlea)
SRX: 107714342 107719155(sqle)
IPU: 108256332(sqle)
PHYP: 113532934(sqle)
AMEX: 103022030(sqle)
EEE: 113577069(sqle)
TRU: 101073594(sqle)
LCO: 104926267(sqle)
NCC: 104964943(sqle)
MZE: 101469229(sqle)
ONL: 100703372(sqle)
OLA: 101165835(sqle)
XMA: 102218921(sqle)
XCO: 114143874(sqle)
PRET: 103478205(sqle)
CVG: 107090131(sqle)
NFU: 107378852(sqle)
KMR: 108234140(sqle)
ALIM: 106523620(sqle)
AOCE: 111562938(sqle)
CSEM: 103388631(sqle)
POV: 109631985(sqle)
LCF: 108887154(sqle)
SDU: 111227759(sqle)
SLAL: 111658124(sqle)
HCQ: 109507068(sqle)
BPEC: 110171635(sqle)
MALB: 109966629(sqle)
ELS: 105019213(sqle)
SFM: 108940515(sqle)
PKI: 111844075(sqle)
CMK: 103187848(sqle)
RTP: 109919445(sqle)
BFO: 118410114
APLC: 110978788
SKO: 100370736
PCAN: 112573399
LAK: 106169642
AQU: 100632870
ATH: AT1G58440(XF1) AT2G22830(SQE2) AT4G37760(SQE3) AT5G24140(SQP2) AT5G24150(SQP1) AT5G24160(SQE6)
LJA: Lj0g3v0267429.1(Lj0g3v0267429.1) Lj0g3v0267429.2(Lj0g3v0267429.2) Lj0g3v0267429.3(Lj0g3v0267429.3) Lj0g3v0292939.1(Lj0g3v0292939.1) Lj0g3v0298799.2(Lj0g3v0298799.2) Lj1g3v1779010.1(Lj1g3v1779010.1) Lj1g3v1779010.2(Lj1g3v1779010.2) Lj4g3v0412640.1(Lj4g3v0412640.1) Lj5g3v0347610.1(Lj5g3v0347610.1) Lj6g3v2171780.1(Lj6g3v2171780.1) Lj6g3v2171780.2(Lj6g3v2171780.2) Lj6g3v2171780.3(Lj6g3v2171780.3)
DOSA: Os03t0231700-01(Os03g0231700) Os03t0231800-02(Os03g0231800)
BDI: 100839945
ATS: 109744486(LOC109744486)
SBI: 8056854
ZMA: 100274333 100285558(pco148653)
SITA: 101777295
ATR: 18446877
PPP: 112296106
MNG: MNEG_6310
APRO: F751_4796
SCE: YGR175C(ERG1)
ERC: Ecym_6016
KMX: KLMA_30204(ERG1)
NCS: NCAS_0A06930(NCAS0A06930)
NDI: NDAI_0D01990(NDAI0D01990)
TPF: TPHA_0E03160(TPHA0E03160)
TBL: TBLA_0C05980(TBLA0C05980) TBLA_0H02130(TBLA0H02130)
TDL: TDEL_0E04440(TDEL0E04440)
KAF: KAFR_0D01720(KAFR0D01720)
PIC: PICST_75910(ERG1)
SPAA: SPAPADRAFT_62808(ERG1)
CAL: CAALFM_C108590CA(ERG1)
NCR: NCU08280
NTE: NEUTE1DRAFT116406(NEUTE1DRAFT_116406)
MGR: MGG_06139
SSCK: SPSK_03260
MAW: MAC_01304
MAJ: MAA_06325
CMT: CCM_07184
BFU: BCIN_01g00360(Bcerg1)
MBE: MBM_00629
ANG: ANI_1_450034(An03g03770)
ABE: ARB_06092
TVE: TRV_00314
PTE: PTT_17609
ZTR: MYCGRDRAFT_108597(ERG1)
SPO: SPBC713.12(erg1)
CNE: CND06110
CNB: CNBD0290
TASA: A1Q1_01672
ABP: AGABI1DRAFT69774(AGABI1DRAFT_69774)
ABV: AGABI2DRAFT205454(AGABI2DRAFT_205454)
MGL: MGL_0127
MRT: MRET_1190
DDI: DDB_G0293584(sqle)
DFA: DFA_07098(sqle)
SPAR: SPRG_11641
TCR: 509589.20
MCA: MCA2872
MMAI: sS8_2585
CCX: COCOR_01775(ubiF)
MCG: GL4_3111
FTJ: FTUN_7823
 » show all
Reference
1  [PMID:5918046]
  Authors
Cory EJ, Russey WE, Ortiz de Montellano PR.
  Title
2,3-oxidosqualene, an intermediate in the biological synthesis of sterols from squalene.
  Journal
J Am Chem Soc 88:4750-1 (1966)
DOI:10.1021/ja00972a056
Reference
2  [PMID:13438881]
  Authors
TCHEN TT, BLOCH K.
  Title
On the conversion of squalene to lanosterol in vitro.
  Journal
J Biol Chem 226:921-30 (1957)
Reference
3  [PMID:5918048]
  Authors
Van Tamelen EE, Willett JD, Clayton RB, Lord KE.
  Title
Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol.
  Journal
J Am Chem Soc 88:4752-4 (1966)
DOI:10.1021/ja00972a058
Reference
4  [PMID:5438357]
  Authors
Yamamoto S, Bloch K.
  Title
Studies on squalene epoxidase of rat liver.
  Journal
J Biol Chem 245:1670-4 (1970)
Reference
5  [PMID:234459]
  Authors
Ono T, Bloch K
  Title
Solubilization and partial characterization of rat liver squalene epoxidase.
  Journal
J Biol Chem 250:1571-9 (1975)
Reference
6  [PMID:8358382]
  Authors
Satoh T, Horie M, Watanabe H, Tsuchiya Y, Kamei T
  Title
Enzymatic properties of squalene epoxidase from Saccharomyces cerevisiae.
  Journal
Biol Pharm Bull 16:349-52 (1993)
DOI:10.1248/bpb.16.349
Reference
7  [PMID:12467639]
  Authors
Chugh A, Ray A, Gupta JB
  Title
Squalene epoxidase as hypocholesterolemic drug target revisited.
  Journal
Prog Lipid Res 42:37-50 (2003)
DOI:10.1016/S0163-7827(02)00029-2
Reference
8  [PMID:17852349]
  Authors
He F, Zhu Y, He M, Zhang Y
  Title
Molecular cloning and characterization of the gene encoding squalene epoxidase in Panax notoginseng.
  Journal
DNA Seq 19:270-3 (2008)
DOI:10.1080/10425170701575026
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.17
IUBMB Enzyme Nomenclature: 1.14.14.17
ExPASy - ENZYME nomenclature database: 1.14.14.17
BRENDA, the Enzyme Database: 1.14.14.17
CAS: 9029-62-3
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