KEGG   ENZYME: 1.14.14.79
Entry
EC 1.14.14.79               Enzyme                                 

Name
docosahexaenoic acid omega-hydroxylase;
CYP4F3B;
CYP4V2;
docosahexaenoate,NADPH:O2 oxidoreductase (22-hydroxydocosahexaenoate forming)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
docosahexaenoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (22-hydroxydocosahexaenoate-forming)
Reaction(IUBMB)
docosahexaenoate + [reduced NADPH---hemoprotein reductase] + O2 = 22-hydroxydocosahexaenoate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R10795]
Reaction(KEGG)
R10795
Substrate
docosahexaenoate [CPD:C06429];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
22-hydroxydocosahexaenoate [CPD:C20855];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein isolated from human eye tissue. Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy. The enzyme also produces some 21-hydroxydocosahexaenoate. Acts in a similar way on icosapentaenoic acid.
History
EC 1.14.14.79 created 2014 as EC 1.14.13.199, transferred 2018 to EC 1.14.14.79
Orthology
K07427  docosahexaenoic acid omega-hydroxylase
K17726  phylloquinone omega-hydroxylase / docosahexaenoic acid omega-hydroxylase / leukotriene-B4 20-monooxygenase
Genes
HSA: 285440(CYP4V2) 4051(CYP4F3) 8529(CYP4F2)
PTR: 100609185 744981(CYP4V2) 748117(CYP4F3) 748531(CYP4F2)
PPS: 100967411 100969141 100969847 100982619 100985937
GGO: 101125692 101135418 101142243 101152881
PON: 100172140(CYP4V2) 100434096 100437847 100453229
NLE: 100579320 100588006 100602871 115836096 115836968
MCC: 696520(CYP4V2) 718349 719317
MCF: 102130440(CYP4F3v2) 102134301(CYP4F45) 102141321
CSAB: 103234079 103234089 103236636
RRO: 104661012 104661014 104673816
CJC: 100408123(CYP4V2) 100411160 100412575(CYP4F2)
MMU: 102294(Cyp4v3)
MCAL: 110300005
MPAH: 110337006
RNO: 266761(Cyp4v3)
MUN: 110558009
CGE: 100750743
NGI: 103750492
HGL: 101716986
CCAN: 109684291
CFA: 102152484
VVP: 112934751
AML: 100468607
UMR: 103681006
UAH: 113262286
ORO: 101378686
ELK: 111144567
FCA: 101097556
PTG: 102960154
PPAD: 109250992
AJU: 106982209
BTA: 510156(CYP4V2)
BOM: 102268997
BIU: 109553482
BBUB: 102394892
CHX: 102188826
OAS: 101116121
SSC: 100113469(CYP4V2)
CFR: 102512100
CDK: 105102385
BACU: 102999883
LVE: 103081363
OOR: 101278344
DLE: 111173427
PCAD: 102990897
ECB: 100056687
EPZ: 103543058
EAI: 106840365
MNA: 107534032
HAI: 109395858
PALE: 102883230
RAY: 107510438
MJV: 108396407
LAV: 100661067
TMU: 101342431
MDO: 100014017
SHR: 100917708
PCW: 110222598
OAA: 100090407
GGA: 415121(CYP4V2)
MGP: 100549160
CJO: 107313678
APLA: 101790057
ACYG: 106035235
TGU: 100230859
LSR: 110484918
SCAN: 103825461
GFR: 102033190
FAB: 101813952
PHI: 102107875
PMAJ: 107203122
CCAE: 111927975
CCW: 104690591
ETL: 114067779
FPG: 101918235
FCH: 102054486
CLV: 102094289
EGZ: 104129484
NNI: 104021298
ACUN: 113479206
PADL: 103922516
AAM: 106484032
AMJ: 102563402(CYP4V2) 102563645(CYP4V2) 102570586
ACS: 100557625
PVT: 110077895
PBI: 103052236
PMUR: 107302659
TSR: 106542020
GJA: 107121984
XLA: 100337567(cyp4v4) 444482(cyp4v2.1.L)
XTR: 100485929(cyp4v2.1) 780124(cyp4v2.2)
DRE: 558851(cyp4v8) 562008(cyp4v7)
CCAR: 109073701
IPU: 108260937 108269274(CYP4V2)
EEE: 113579251
TRU: 101061436
LCO: 104917763
NCC: 104952998
MZE: 101485601
ONL: 100703355
OLA: 101162575
XMA: 102237202
XCO: 114145628
PRET: 103461721
NFU: 107374000
KMR: 108231369
AOCE: 111582916
CSEM: 103384330
POV: 109641907
LCF: 108901662
SDU: 111216661
SLAL: 111663247
HCQ: 109510969
MALB: 109968238
LCM: 102361464
CMK: 103178199
RTP: 109916600
BFO: 118407885
APLC: 110987520
SKO: 100375440
AAG: 5567661
AALB: 109411363
ATD: 109606373
BMOR: 101742342
BMAN: 114253007
CLEC: 106672025
FCD: 110862369
DPTE: 113793077
CEL: CELE_Y80D3A.5(cyp-42A1)
CBR: CBG20323(Cbr-cyp-42A1)
TSP: Tsp_10837
PCAN: 112556660
MYI: 110451224
LAK: 106156039
EPA: 110235098
 » show all
Reference
1  [PMID:22772592]
  Authors
Nakano M, Kelly EJ, Wiek C, Hanenberg H, Rettie AE
  Title
CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of omega-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant.
  Journal
Mol Pharmacol 82:679-86 (2012)
DOI:10.1124/mol.112.080085
  Sequence
[hsa:285440]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.79
IUBMB Enzyme Nomenclature: 1.14.14.79
ExPASy - ENZYME nomenclature database: 1.14.14.79
BRENDA, the Enzyme Database: 1.14.14.79
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