KEGG   ENZYME: 1.14.14.85
Entry
EC 1.14.14.85               Enzyme                                 

Name
7-deoxyloganate 7-hydroxylase;
CYP72A224 (gene name);
7-deoxyloganin 7-hydroxylase (incorrect);
7-deoxyloganin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating) (incorrect)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
7-deoxyloganate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating)
Reaction(IUBMB)
7-deoxyloganate + [reduced NADPH---hemoprotein reductase] + O2 = loganate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R05832]
Reaction(KEGG)
R05832;
(other) R03556
Substrate
7-deoxyloganate [CPD:C11636];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
loganate [CPD:C01512];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the plant Catharanthus roseus, is a cytochrome P-450 (heme-thiolate) enzyme. It catalyses a reaction in the pathway leading to biosynthesis of monoterpenoid indole alkaloids.
History
EC 1.14.14.85 created 2002 as EC 1.14.13.74, transferred 2018 to EC 1.14.14.85, modified 2018
Pathway
ec00902  Monoterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K23276  7-deoxyloganate 7-hydroxylase
Reference
1  [PMID:11524113]
  Authors
Katano N, Yamamoto H, Iio R, Inoue K.
  Title
7-Deoxyloganin 7-hydroxylase in Lonicera japonica cell cultures.
  Journal
Phytochemistry 58:53-8 (2001)
DOI:10.1016/S0031-9422(01)00181-9
Reference
2  [PMID:24710322]
  Authors
Miettinen K, Dong L, Navrot N, Schneider T, Burlat V, Pollier J, Woittiez L, van der Krol S, Lugan R, Ilc T, Verpoorte R, Oksman-Caldentey KM, Martinoia E, Bouwmeester H, Goossens A, Memelink J, Werck-Reichhart D.
  Title
The seco-iridoid pathway from Catharanthus roseus.
  Journal
Nat Commun 5:3606 (2014)
DOI:10.1038/ncomms4606
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.85
IUBMB Enzyme Nomenclature: 1.14.14.85
ExPASy - ENZYME nomenclature database: 1.14.14.85
BRENDA, the Enzyme Database: 1.14.14.85
CAS: 335305-40-3
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