KEGG   ENZYME: 1.14.19.11Help
Entry
EC 1.14.19.11               Enzyme                                 

Name
acyl-[acyl-carrier-protein] 4-desaturase;
Delta4-palmitoyl-[acyl carrier protein] desaturase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
BRITE hierarchy
Sysname
palmitoyl-[acyl-carrier protein],reduced acceptor:oxygen oxidoreductase (4,5 cis-dehydrogenating)
Reaction(IUBMB)
palmitoyl-[acyl-carrier protein] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = (4Z)-hexadec-4-enoyl-[acyl-carrier protein] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O [RN:R11108]
Reaction(KEGG)
Substrate
palmitoyl-[acyl-carrier protein] [CPD:C05764];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
(4Z)-hexadec-4-enoyl-[acyl-carrier protein] [CPD:C21114];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139];
H2O [CPD:C00001]
Comment
The enzymes from the plants Coriandrum sativum (coriander) and Hedera helix (English ivy) are involved in biosynthesis of petroselinate [(6Z)-octadec-6-enoate], which is formed by elongation of (4Z)-hexadec-4-enoate. The ivy enzyme can also act on oleoyl-[acyl-carrier protein] and palmitoleoyl-[acyl-carrier protein], generating the corresponding 4,9-diene.
History
EC 1.14.19.11 created 2015
Orthology
K03921  acyl-[acyl-carrier-protein] desaturase
Genes
ATH: AT1G43800(FTM1) AT2G43710(SSI2) AT3G02610 AT3G02620 AT3G02630 AT5G16230 AT5G16240
ALY: ARALYDRAFT_477504 ARALYDRAFT_488473 ARALYDRAFT_670995 ARALYDRAFT_891368 ARALYDRAFT_903770 ARALYDRAFT_909604
CRB: 17881420 17884225 17887583 17892070 17892815 17897283
CSAT: 104703073 104705911 104705912 104735648 104735649 104742149 104744342 104744343 104757931 104763879 104763880 104769885 104769886 104777112 104777214 104782900 104784970 104793309(SAD3)
EUS: EUTSA_v10001477mg EUTSA_v10011783mg EUTSA_v10012283mg EUTSA_v10013713mg EUTSA_v10013733mg EUTSA_v10020875mg
BRP: 103843412 103846343 103846344 103858091 103858976 103866745 103870910
BNA: 106360893 106366808 106366809 106372016 106372017 106372205 106379047 106387283 106388339 106396242 106438946 106447152 111197705
BOE: 106294068 106313000 106319191 106335862 106336467 106342438
RSZ: 108805325 108813074 108814102 108817491 108835283 108847440 108855347 108857870
THJ: 104802328 104802432 104802433 104804087 104806847 104827165
TCC: 18592535(SAD7) 18598496(SAD2) 18601170(SAD5) 18602344(SAD1) 18602345(SAD4) 18602347(SAD3)
GMX: 100037478(SACPD-C) 100217331(SAD2) 100816146(SACPD) 547808(ACPD)
LJA: Lj0g3v0353059.1(Lj0g3v0353059.1) Lj1g3v0264200.1(Lj1g3v0264200.1) Lj4g3v0510250.1(Lj4g3v0510250.1)
DOSA: Os01t0880800-01(Os01g0880800) Os01t0919900-01(Os01g0919900) Os02t0504800-01(Os02g0504800) Os03t0423300-01(Os03g0423300) Os03t0741000-00(Os03g0741000) Os04t0379900-01(Os04g0379900) Os06t0503800-00(Os06g0503800) Os08t0199400-01(Os08g0199400) Os08t0200100-01(Os08g0200100)
ATS: 109737747(LOC109737747) 109742804(LOC109742804) 109743731(LOC109743731) 109747362(LOC109747362) 109748642(LOC109748642) 109748975(LOC109748975) 109749248(LOC109749248) 109759486(LOC109759486) 109763251(LOC109763251) 109763252(LOC109763252) 109766563(LOC109766563) 109779328(LOC109779328) 109782689(LOC109782689)
TPS: THAPSDRAFT_bd1192(DES7)
SCL: sce2527
BCZ: BCE33L2881(staD)
BTI: BTG_03995
BWW: bwei_3845(staD)
BMYO: BG05_2756
BMYC: DJ92_5455
ESI: Exig_2392
EAN: Eab7_2235
PMW: B2K_01300
ASOC: CB4_01449(desA1)
BTS: Btus_3008
SAY: TPY_2839
MTU: Rv0824c(desA1)
MTC: MT0846
MRA: MRA_0834(desA1)
MTUR: CFBS_0865(desA1)
MTO: MTCTRI2_0841(desA1)
MTD: UDA_0824c(desA1)
MTN: ERDMAN_0907(desA1)
MTUC: J113_05775
MTUE: J114_04385
MTUH: I917_05820
MTUL: TBHG_00813
MTUT: HKBT1_0866(desA1)
MTUU: HKBT2_0866(desA1)
MTQ: HKBS1_0865(desA1)
MBO: BQ2027_MB0847C(desA1)
MBB: BCG_0877c(desA1)
MBT: JTY_0847(desA1)
MBM: BCGMEX_0848c(desA1)
MBX: BCGT_0624
MAF: MAF_08340(desA1)
MMIC: RN08_0920
MCE: MCAN_08271(desA1)
MCQ: BN44_10898(desA)
MCV: BN43_20267(desA)
MCX: BN42_20586(desA)
MCZ: BN45_20093(desA)
MLE: ML2185(desA1)
MLB: MLBr02185(desA1)
MPA: MAP_0658c(desA1)
MAVI: RC58_15915
MAVU: RE97_15945
MIT: OCO_06740
MIA: OCU_06800
MID: MIP_01188
MYO: OEM_06830
MIR: OCQ_06900
MUL: MUL_0445(desA1) MUL_3646(desA1_1)
MMI: MMAR_3704(desA1_1) MMAR_4856(desA1)
MMAE: MMARE11_36110(desA1_1) MMARE11_46640(desA1)
MMM: W7S_03315
MLI: MULP_03954(desA1_1) MULP_05089(desA1)
MSHG: MSG_02390 MSG_04355(desA1)
MSG: MSMEI_5619(des)
MGI: Mflv_1668
MPHL: MPHLCCUG_00726(desA1_1) MPHLCCUG_05145(desA1_2)
MVQ: MYVA_4940
MHAS: MHAS_03582(desA1)
MSAL: DSM43276_00673(desA1_1) DSM43276_01869(desA1_2) DSM43276_02252(desA1_3) DSM43276_03143(desA1_4) DSM43276_04258(desA1_5)
MJD: JDM601_0873(desA1_1) JDM601_3526(desA1)
NFA: NFA_6080
RER: RER_47900(desA1)
REY: O5Y_22685
ROP: ROP_49510(desA1)
REQ: REQ_08730
RFA: A3L23_00640(desA1_1) A3L23_00758(desA1_2) A3L23_01498(desA1_3) A3L23_01832(desA1_4) A3L23_03015(desA1_5)
RHS: A3Q41_00308(desA1_1) A3Q41_01533(desA1_2) A3Q41_01860(desA1_3) A3Q41_02594(desA1_4) A3Q41_02715(desA1_5)
RHU: A3Q40_02386(desA1_1) A3Q40_02652(desA1_2) A3Q40_02779(desA1_3)
GRU: GCWB2_14585(desA4) GCWB2_19715(desA8)
GOM: D7316_00659(desA1_1) D7316_01574(desA1_2) D7316_02295(desA1_3)
SCO: SCO6717(SC4C6.27c)
SALB: XNR_0316
SMA: SAVERM_1691(desA)
SGR: SGR_1008
SGB: WQO_30535
SFA: Sfla_0689
SHY: SHJG_7615
SVE: SVEN_6398
SDV: BN159_1702(desA1)
SALS: SLNWT_0409
STRP: F750_6176
SFI: SFUL_6491
SALU: DC74_3164
SALL: SAZ_16890
SLV: SLIV_04925(desA1)
SGU: SGLAU_28080(desA1)
STRE: GZL_05766
STRM: M444_27940
SAMB: SAM23877_6369(desA)
SPRI: SPRI_1049
SRW: TUE45_07262(desA1)
SLE: sle_11110(sle_11110)
SRN: A4G23_05001(desA1)
SNR: SNOUR_27115(desA1)
SMAL: SMALA_2648
SLAU: SLA_6346
SALJ: SMD11_4487
SLX: SLAV_07635(desA1)
SGE: DWG14_01447(desA1)
KSK: KSE_54350(desA)
LMOI: VV02_01125
NDK: I601_2941(desA1)
KFL: Kfla_7030
TCU: Tcur_3578
SRO: Sros_1903
FAL: FRAAL0670
NML: Namu_0992
MMAR: MODMU_5493
AMD: AMED_4117
AMN: RAM_20980
AMM: AMES_4069
AMZ: B737_4069
AOI: AORI_1632
SAQ: Sare_1811
MIL: ML5_2412
CAI: Caci_2173
AYM: YM304_36700(desA)
HAU: Haur_0733
DGE: Dgeo_0121
DGO: DGo_CA2715(staD)
TRA: Trad_2440
PLH: VT85_13645(desA1_1) VT85_24455(desA1_2)
GES: VT84_22280(desA1)
PBOR: BSF38_01549(desA1)
ABAC: LuPra_05096(desA1)
GAU: GAU_3746
GBA: J421_1125
PHE: Phep_1163
SMIZ: 4412673_02968(desA1)
MUC: MuYL_4091
MGOT: MgSA37_04262(desA1)
DFE: Dfer_5690
SLI: Slin_4583
LBY: Lbys_3166
FAE: FAES_2147
HSW: Hsw_2548
GFO: GFO_3404
GFL: GRFL_1514
FJO: Fjoh_0968
FJG: BB050_01640(desA1)
FIN: KQS_13090
ZPR: ZPR_0309
MARM: YQ22_07090
CBAL: M667_03965
CBAT: M666_03910
ZGA: ZOBELLIA_1485(ACPD)
NDO: DDD_1638
EAO: BD94_2620
ELB: VO54_00092(desA1)
MYR: MYRA21_1005(desA)
MPW: MPR_3539
CHZ: CHSO_2306
CTAK: 4412677_00299(desA1)
WIN: WPG_1455
TMAR: MARIT_0197
AALG: AREALGSMS7_01036(desA1)
KOS: KORDIASMS9_00959(desA1)
MARF: CJ739_1383
FBA: FIC_01332
IAL: IALB_0537
 » show all
Taxonomy
Reference
1  [PMID:1454797]
  Authors
Cahoon EB, Shanklin J, Ohlrogge JB
  Title
Expression of a coriander desaturase results in petroselinic acid production in transgenic tobacco.
  Journal
Proc Natl Acad Sci U S A 89:11184-8 (1992)
DOI:10.1073/pnas.89.23.11184
Reference
2  [PMID:12232129]
  Authors
Cahoon EB, Ohlrogge JB
  Title
Metabolic Evidence for the Involvement of a [delta]4-Palmitoyl-Acyl Carrier Protein Desaturase in Petroselinic Acid Synthesis in Coriander Endosperm and Transgenic Tobacco Cells.
  Journal
Plant Physiol 104:827-837 (1994)
Reference
3  [PMID:15939740]
  Authors
Whittle E, Cahoon EB, Subrahmanyam S, Shanklin J
  Title
A multifunctional acyl-acyl carrier protein desaturase from Hedera helix L. (English ivy) can synthesize 16- and 18-carbon monoene and diene products.
  Journal
J Biol Chem 280:28169-76 (2005)
DOI:10.1074/jbc.M504205200
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.11
IUBMB Enzyme Nomenclature: 1.14.19.11
ExPASy - ENZYME nomenclature database: 1.14.19.11
BRENDA, the Enzyme Database: 1.14.19.11
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