EC                Enzyme                                 

acyl-CoA 6-desaturase;
Delta6-fatty acyl-CoA desaturase;
Delta6-acyl CoA desaturase;
fatty acid Delta6-desaturase;
fatty acid 6-desaturase;
linoleate desaturase;
linoleic desaturase;
linoleic acid desaturase;
linoleoyl CoA desaturase;
linoleoyl-coenzyme A desaturase;
long-chain fatty acid Delta6-desaturase;
linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase;
linoleoyl-CoA desaturase;
FADS2 (gene name)
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
BRITE hierarchy
acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (6,7 cis-dehydrogenating)
(1) linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R03814];
(2) alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R07933]
linoleoyl-CoA [CPD:C02050];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080];
alpha-linolenoyl-CoA [CPD:C16162]
gamma-linolenoyl-CoA [CPD:C03035];
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001];
stearidonoyl-CoA [CPD:C16163]
An iron protein. The enzyme introduces a cis double bond at carbon 6 of acyl-CoAs. It is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. The human enzyme has a broad substrate range. It also acts on palmitoyl-CoA, generating sapienoyl-CoA [4], and on (9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoyl-CoA, converting it to (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoyl-CoA as part of a pathway that produces docosahexaenoate [3]. The enzyme contains a cytochrome b5 domain that is assumed to act in vivo as the electron donor to the active site of the desaturase.
EC created 1986 as EC, transferred 2000 to EC, modified 2015
ec00591  Linoleic acid metabolism
ec01040  Biosynthesis of unsaturated fatty acids
ec01100  Metabolic pathways
K00508  linoleoyl-CoA desaturase
K10226  acyl-CoA 6-desaturase (Delta-6 desaturase)
HSA: 9415(FADS2)
PTR: 451244(FADS2)
PPS: 100980611(FADS2)
GGO: 109024898(FADS2)
PON: 100190814(FADS2)
NLE: 100596455(FADS2)
MCC: 719037(FADS2)
MCF: 101926688(FADS2)
CSAB: 103234245(FADS2)
RRO: 104679373(FADS2)
RBB: 108533600(FADS2)
CJC: 100387410(FADS2) 103796370
SBQ: 101051429(FADS2)
MMU: 56473(Fads2)
MCAL: 110285898(Fads2)
MPAH: 110322460(Fads2)
RNO: 83512(Fads2)
MUN: 110548092(Fads2)
CGE: 100757464(Fads2)
NGI: 103729125(Fads2)
HGL: 101726663(Fads2)
CCAN: 109695673(Fads2)
OCU: 100352712(FADS2)
TUP: 102475407(FADS2)
CFA: 483792(FADS2)
VVP: 112911087(FADS2)
AML: 100470289(FADS2)
UMR: 103678231(FADS2)
UAH: 113246983(FADS2)
ORO: 101364529(FADS2)
FCA: 101085071(FADS2)
PTG: 102968308(FADS2)
PPAD: 109246554(FADS2)
AJU: 106986967(FADS2)
BTA: 521822(FADS2)
BOM: 102275533(FADS2)
BIU: 109554370(FADS2)
BBUB: 102396145 102405983(FADS2)
CHX: 100861212(FADS2) 102171133(FADS2)
OAS: 101108497 101108615(FADS2)
SSC: 444997(FADS2)
CFR: 102506325(FADS2) 102523732
CDK: 105091525(FADS2) 105104977
BACU: 103000252(FADS2)
LVE: 103083143(FADS2)
OOR: 101275563(FADS2)
DLE: 111183883(FADS2)
PCAD: 102993101 114487991(FADS2)
ECB: 100062709(FADS2)
EPZ: 103543786 103567043(FADS2)
EAI: 106847560(FADS2)
MYB: 102261893(FADS2)
MYD: 102773468(FADS2)
MNA: 107527684(FADS2)
HAI: 109390019(FADS2)
DRO: 112317237(FADS2)
PALE: 102894063(FADS2)
RAY: 107501589(FADS2)
MJV: 108407763(FADS2)
LAV: 100677680
TMU: 101347025
MDO: 100009895(FADS2)
SHR: 100930034(FADS2)
PCW: 110195307(FADS2)
OAA: 100086288
GGA: 423122(FADS2)
MGP: 100549977(FADS2)
CJO: 107314439(FADS2)
NMEL: 110400735(FADS2)
APLA: 101798758(FADS2)
ACYG: 106033870
TGU: 100222881(FADS2)
LSR: 110484926(FADS2)
SCAN: 103822123(FADS2)
GFR: 102040567(FADS2)
FAB: 101810111(FADS2)
PHI: 102112585(FADS2)
PMAJ: 107205402(FADS2)
CCAE: 111930632
CCW: 104697641
ETL: 114067866
FPG: 101910606(FADS2)
FCH: 102058085(FADS2)
CLV: 102098615(FADS2)
EGZ: 104122147
NNI: 104009393(FADS2)
ACUN: 113481354
PADL: 103925785(FADS2)
AAM: 106490046
ASN: 102382989
AMJ: 102563693(FADS2)
PSS: 102460236(FADS2)
CMY: 102933275(FADS2)
CPIC: 101936434
ACS: 100551818(fads2)
PVT: 110086191(FADS2)
PBI: 103050551(FADS2)
TSR: 106538426(FADS2) 106550281
PMUA: 114600538
GJA: 107108854(FADS2)
XLA: 399058(fads2.S) 446688(fads2.L)
XTR: 100145314(fads2)
NPR: 108794176(FADS2)
DRE: 140615(fads2)
SRX: 107754339
IPU: 100305117(fads2) 108275104
AMEX: 103027972(fads2)
EEE: 113588191(fads2)
LCO: 104937137(fads2)
NCC: 104956187(fads2)
AOCE: 111582148(fads2)
CSEM: 103380276(fads2)
POV: 109623584(fads2)
LCF: 108886851(fads2)
SDU: 111229900(fads2)
SLAL: 111666947(fads2)
HCQ: 109507604(fads2)
BPEC: 110167702(fads2)
SASA: 100136383(fadsd5) 100136441(fadsd6) 100329172(d6fadc) 100337624(d6fad_b) 106584797(D6fad_b) 106590822(D6fad_b)
OTW: 112264870
SALP: 112071110
ELS: 105018065(fads2)
LCM: 102349949(FADS2)
CMK: 103174861(fads2)
RTP: 109937250(fads2)
FCD: 110845258
OBI: 106867675
SHX: MS3_06568
AQU: 100632154
ECC: c1695
ESE: ECSF_1212
ELC: i14_1525
ELD: i02_1525
ELF: LF82_208
ECOJ: P423_06960
ECOS: EC958_1504
EFE: EFER_1726
EEC: EcWSU1_02601(des6)
SRL: SOD_c26990(des1) SOD_c27000(des)
ECA: ECA0116
PCT: PC1_4135
XCC: XCC3878
XCB: XC_3964
XCP: XCR_0405
XCV: XCV4052
XAX: XACM_3829
XAC: XAC3959
XCI: XCAW_00342(desA)
XOO: XOO4446(DesA)
XOM: XOO4186(XOO4186)
XOP: PXO_03878(desA3)
XOR: XOC_4266
XAL: XALC_2600
XPH: XppCFBP6546_14725(XppCFBP6546P_14725)
SML: Smlt2831
SMT: Smal_2285
SMZ: SMD_2477
PSD: DSC_07755
LEZ: GLE_4391
LEM: LEN_0825
DKO: I596_2530
PAE: PA4888(desB)
PAEV: N297_5058
PAEI: N296_5058
PAG: PLES_52741(desB)
PAF: PAM18_5000(desB)
PAEP: PA1S_26540
PAEM: U769_26805
PAEL: T223_27000
PAEU: BN889_05439(desB)
PAEG: AI22_07455
PAEC: M802_5056
PAEO: M801_4923
PMY: Pmen_0669
PMK: MDS_0755
PPSE: BN5_0558
PCQ: PcP3B5_56390(desA3)
PKC: PKB_5205(desA3)
ACB: A1S_2458
ABN: AB57_2885
ABX: ABK1_2787
ABH: M3Q_2969
ABAD: ABD1_24450
ABAZ: P795_4665
ABAU: IX87_08950
ABAA: IX88_15485
ACC: BDGL_001925(des6)
GPS: C427_2135
APAC: S7S_15795
TOL: TOL_2040
CVI: CV_1644(desD) CV_2452
BUB: BW23_4705
BSTG: WT74_24150
ADE: Adeh_1021
CCX: COCOR_07436(des6)
HOH: Hoch_5632
SYN: sll0262(desD(des6))
SYZ: MYO_119490(desD(des6))
SYY: SYNGTS_1931(desD)
SYT: SYNGTI_1930(desD)
SYS: SYNPCCN_1929(desD)
SYQ: SYNPCCP_1929(desD)
SYJ: D082_30330(desD)
AMR: AM1_1073
MAR: MAE_48160(desD)
MPK: VL20_3454
MVZ: myaer102_21530(desD)
ARP: NIES39_J03090(desD)
PAGH: NIES204_12070(desD)
PUV: PUV_10250(des6)
WCH: wcw_0161
FMR: Fuma_00671(desA)
SACI: Sinac_0398
DORI: FH5T_15505
CPI: Cpin_5677
PHE: Phep_0579
SMIZ: 4412673_01383(desA3_1) 4412673_04012(desA3_2)
SLI: Slin_4655
FAE: FAES_3358 FAES_4414(desD)
FJG: BB050_00859(desA3_1) BB050_02987(desA3_2)
FPS: FP0413
FIN: KQS_11875
ZPR: ZPR_0940
MARM: YQ22_03825
CBAL: M667_08640
CBAT: M666_08605
DDO: I597_1302(desA3)
ZGA: ZOBELLIA_1067(des6-2) ZOBELLIA_755(des6-1)
MLT: VC82_2131
EAO: BD94_3599
CHZ: CHSO_0007
WIN: WPG_2001
AALG: AREALGSMS7_02543(desA3)
MARF: CJ739_552
SRG: XF24_00844(desA3)
 » show all
1  [PMID:7212717]
Okayasu T, Nagao M, Ishibashi T, Imai Y.
Purification and partial characterization of linoleoyl-CoA desaturase from rat liver microsomes.
Arch Biochem Biophys 206:21-8 (1981)
2  [PMID:9867867]
Cho HP, Nakamura MT, Clarke SD
Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase.
J Biol Chem 274:471-7 (1999)
[hsa:9415] [mmu:56473]
3  [PMID:10903473]
Sprecher H
Metabolism of highly unsaturated n-3 and n-6 fatty acids.
Biochim Biophys Acta 1486:219-31 (2000)
4  [PMID:12713571]
Ge L, Gordon JS, Hsuan C, Stenn K, Prouty SM
Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity.
J Invest Dermatol 120:707-14 (2003)
5  [PMID:15769252]
Domergue F, Abbadi A, Zahringer U, Moreau H, Heinz E
In vivo characterization of the first acyl-CoA Delta6-desaturase from a member of the plant kingdom, the microalga Ostreococcus tauri.
Biochem J 389:483-90 (2005)
Other DBs
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IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 9082-66-0
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