KEGG   ENZYME: 1.14.19.53Help
Entry
EC 1.14.19.53               Enzyme                                 

Name
all-trans-retinol 3,4-desaturase;
CYP27C1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
BRITE hierarchy
Sysname
all-trans-retinol,reduced adrenodoxin:oxygen 3,4-oxidoreductase
Reaction(IUBMB)
all-trans-retinol + 2 reduced adrenodoxin + 2 H+ + O2 = all-trans-3,4-didehydroretinol + 2 oxidized adrenodoxin + 2 H2O [RN:R11952]
Reaction(KEGG)
Substrate
all-trans-retinol [CPD:C00473];
reduced adrenodoxin [CPD:C00662];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
all-trans-3,4-didehydroretinol [CPD:C21797];
oxidized adrenodoxin [CPD:C00667];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme thiolate) enzyme found in vertebrates. The enzyme is also active with retinal and retinoic acid.
History
EC 1.14.19.53 created 2018
Pathway
ec00830  Retinol metabolism
Orthology
K17951  all-trans-retinol 3,4-desaturase
Genes
HSA: 339761(CYP27C1)
PTR: 470525
PPS: 100975504
GGO: 101148971
PON: 100453764
NLE: 100600882
MCC: 713954
MCF: 102138872
CSAB: 103216882(CYP27C1)
RRO: 104662434
RBB: 108533024
CJC: 100407433
SBQ: 101050984
OCU: 100355448
TUP: 102486613
CFA: 483869(CYP27C1)
VVP: 112932715
AML: 100475175
UMR: 103658573
UAH: 113263376
ORO: 101369154
FCA: 101096908
PTG: 102957625
PPAD: 109278795
AJU: 106966380
BTA: 617338(CYP27C1)
BOM: 102274061
BIU: 109565330
BBUB: 102407599
CHX: 102179328
OAS: 101118856
SSC: 100517560
CFR: 102504552
CDK: 105084485
BACU: 103017184
LVE: 103083694
OOR: 101269815
DLE: 111183411
PCAD: 102981411
ECB: 100051659(CYP27C1)
EPZ: 103562192
EAI: 106834094
TMU: 101354619
MDO: 100026810
SHR: 100916977
PCW: 110194704
OAA: 100089911
GGA: 424227(CYP27C1)
MGP: 100542744
CJO: 107316860
NMEL: 110399800
APLA: 101801511
TGU: 100225584
LSR: 110468322
SCAN: 103814334
GFR: 102033475
FAB: 101811458
PHI: 102112535
PMAJ: 107207282
CCAE: 111932211
CCW: 104693991
ETL: 114055572
FPG: 101921287
CLV: 102092786
EGZ: 104133721
NNI: 104020396
ACUN: 113482262
PADL: 103916539
AAM: 106499209
ASN: 102378794
AMJ: 102574953(CYP27C1)
PSS: 102448341
CMY: 102940478
CPIC: 101935484
ACS: 100557779
PVT: 110085301
PBI: 103048791
PMUR: 107302019
GJA: 107113561
XLA: 108701260 447625(cyp27c1.L) 735141
XTR: 496805(cyp27c1)
NPR: 108785388
DRE: 558396(cyp27c1)
IPU: 108272716
PHYP: 113538219
AMEX: 103026207
EEE: 113584084
TRU: 101074060
LCO: 104918263
MZE: 101466396
ONL: 100700192
OLA: 101157281
XMA: 102223373
XCO: 114142722
PRET: 103461994
CVG: 107082507
NFU: 107381651
KMR: 108250623
ALIM: 106513953
AOCE: 111564848
CSEM: 103398814
POV: 109624782
LCF: 108887985
SDU: 111238623
SLAL: 111652557
HCQ: 109524630
BPEC: 110173034
MALB: 109964498
ELS: 105020091
PKI: 111852224
LCM: 102367688
RTP: 109912647
MYI: 110458452
LAK: 106175024
AQU: 100637286
 » show all
Taxonomy
Reference
1  [PMID:26549260]
  Authors
Enright JM, Toomey MB, Sato SY, Temple SE, Allen JR, Fujiwara R, Kramlinger VM, Nagy LD, Johnson KM, Xiao Y, How MJ, Johnson SL, Roberts NW, Kefalov VJ, Guengerich FP, Corbo JC
  Title
Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2.
  Journal
Curr Biol 25:3048-57 (2015)
DOI:10.1016/j.cub.2015.10.018
  Sequence
[dre:558396]
Reference
2  [PMID:27059013]
  Authors
Kramlinger VM, Nagy LD, Fujiwara R, Johnson KM, Phan TT, Xiao Y, Enright JM, Toomey MB, Corbo JC, Guengerich FP
  Title
Human cytochrome P450 27C1 catalyzes 3,4-desaturation of retinoids.
  Journal
FEBS Lett 590:1304-12 (2016)
DOI:10.1002/1873-3468.12167
  Sequence
[hsa:339761]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.53
IUBMB Enzyme Nomenclature: 1.14.19.53
ExPASy - ENZYME nomenclature database: 1.14.19.53
BRENDA, the Enzyme Database: 1.14.19.53
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