KEGG   ENZYME: 1.14.99.50
Entry
EC 1.14.99.50               Enzyme                                 

Name
gamma-glutamyl hercynylcysteine S-oxide synthase;
EgtB
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
Sysname
hercynine,gamma-L-glutamyl-L-cysteine:oxygen oxidoreductase [gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide-forming]
Reaction(IUBMB)
hercynine + gamma-L-glutamyl-L-cysteine + O2 = gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O [RN:R11013]
Reaction(KEGG)
R11013
Substrate
hercynine [CPD:C05575];
gamma-L-glutamyl-L-cysteine [CPD:C00669];
O2 [CPD:C00007]
Product
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide [CPD:C20995];
H2O [CPD:C00001]
Comment
Requires Fe2+ for activity. The enzyme, found in bacteria, is specific for both hercynine and gamma-L-glutamyl-L-cysteine. It is part of the biosynthesis pathway of ergothioneine.
History
EC 1.14.99.50 created 2015
Pathway
ec00340  Histidine metabolism
ec01100  Metabolic pathways
Orthology
K18912  gamma-glutamyl hercynylcysteine S-oxide synthase
Genes
SACZ: AOT14_23530
STEK: AXG53_17280
PMEX: H4W19_15905
LAB: LA76x_4692
LAQ: GLA29479_5048
LCP: LC55x_0350
LGU: LG3211_0373
LEZ: GLE_0191
LEM: LEN_4741
LMB: C9I47_0976
PAGR: E2H98_13110(egtB)
MAQ: Maqu_3454
MHC: MARHY3337
MAD: HP15_3232
MARA: D0851_10180(egtB)
MARJ: MARI_31950(egtB_2)
TGR: Tgr7_2475
TKM: TK90_0939
TVR: TVD_07845
SPIZ: GJ672_01325(egtB)
HCO: LOKO_03727(egtB)
SVA: SVA_1069
SALN: SALB1_3450
TBN: TBH_C2361
ENM: EBS_0581
COX: E0W60_01320(egtB)
BPH: Bphy_4432
BFN: OI25_6295(egtB)
PMEG: FNZ07_07500(egtB)
CABA: SBC2_69120(egtB_3)
RFR: Rfer_1619
RHF: EUB48_06585(egtB) EUB48_07140(egtB)
POL: Bpro_1756
PNA: Pnap_1506
POS: DT070_00320(egtB)
POO: F7R28_09125(egtB)
LIH: L63ED372_02889(egtB)
HYR: BSY239_2994(egtB)
HYB: Q5W_23760
HYC: E5678_11545(egtB)
MMS: mma_1200
JAG: GJA_1593
JAJ: EKL02_07895(egtB)
JAS: FJQ89_00005(egtB)
JLV: G3257_11140(egtB)
MFLA: GO485_26330(egtB)
UPV: EJN92_10180(egtB)
UPI: EJG51_013050(egtB)
LCH: Lcho_1725
RGE: RGE_39310
METR: BSY238_3070(egtB)
TBD: Tbd_1022
SLT: Slit_2647
NIM: W01_19350
TCL: Tchl_2728
BPRC: D521_1362
ADE: Adeh_2207
MXA: MXAN_7471
MPO: Mpop_5439
MOR: MOC_1628
GOH: B932_1130
BSL: A7A1_1791
BSH: BSU6051_07480(yfmG)
BSUT: BSUB_00822
BSUL: BSUA_00822(yfmG)
BSUS: Q433_04225
BST: GYO_1013
BACL: BS34A_08460(egtB)
BTS: Btus_1664
MTU: Rv3703c(etgB)
MTC: MT3806
MRA: MRA_3739
MTUR: CFBS_3924
MTD: UDA_3703c
MTUE: J114_19780
MTUH: I917_25965
MTUL: TBHG_03638
MTUT: HKBT1_3908
MTUU: HKBT2_3918
MBB: BCG_3762c
MBT: JTY_3764
MBX: BCGT_3565
MAF: MAF_37110
MMIC: RN08_4083
MPA: MAP_0305c
MAO: MAP4_3566
MAVI: RC58_17720
MAVU: RE97_17750
MAV: MAV_0400
MIT: OCO_03530
MIA: OCU_03600
MID: MIP_00737
MYO: OEM_03650
MIR: OCQ_03550
MUL: MUL_4287
MMC: Mmcs_4881
MKM: Mkms_4970
MJL: Mjls_5249
MMI: MMAR_5214
MMM: W7S_01735
MLI: MULP_05491(egtB)
MHAD: B586_03745
MSHG: MSG_04707(egtB)
MFJ: MFLOJ_39060(egtB)
MXE: MYXE_03630(egtB)
MNV: MNVI_14050(egtB)
MVA: Mvan_5485
MGI: Mflv_1316
MPHL: MPHLCCUG_00352(egtB)
MVQ: MYVA_5375
MTHN: 4412656_04308(egtB)
MHAS: MHAS_03908(egtB)
MDU: MDUV_47500(egtB)
MCHT: MCHIJ_17960(egtB)
MDR: MDOR_34100(egtB)
MAUU: NCTC10437_05230(egtB)
MMAG: MMAD_50030(egtB)
MMOR: MMOR_09290(egtB)
MAB: MAB_0370
MABB: MASS_0366
MCHE: BB28_01805
MSTE: MSTE_00329(egtB)
MSAL: DSM43276_00320(egtB)
MTER: 4434518_03930(egtB)
MMIN: MMIN_14030(egtB)
MHIB: MHIB_32430(egtB)
ASD: AS9A_2109
MKR: MKOR_31820(egtB)
NFA: NFA_48860
NFR: ERS450000_05023(egtB)
NNO: NONO_c66360(egtB)
NAH: F5544_39500(egtB)
NAD: NCTC11293_06260(egtB)
RER: RER_43190
REY: O5Y_20240
ROP: ROP_57700
REQ: REQ_12470
RHB: NY08_2332
RFA: A3L23_00521(egtB)
RHS: A3Q41_02832(egtB)
RHU: A3Q40_02533(egtB)
RRT: 4535765_01115(egtB)
RCR: NCTC10994_01625(egtB)
SCO: SCO0911(SCM1.44)
SALB: XNR_5671
SMA: SAVERM_7340(egtB)
SGR: SGR_696
SGB: WQO_31710
SCT: SCAT_4660
SFA: Sfla_0405
SBH: SBI_01719
SHY: SHJG_7894
SVE: SVEN_6869
SALS: SLNWT_7177
STRP: F750_6594
SFI: SFUL_6745
SALU: DC74_6878
SALL: SAZ_35730
SLV: SLIV_33375(egtB)
SGU: SGLAU_29365(egtB)
STRE: GZL_01888
SLD: T261_1095
STRM: M444_29585
SAMB: SAM23877_6629(egtB)
SPRI: SPRI_0729
SRW: TUE45_00193(egtB)
SLE: sle_06840(sle_06840)
SRN: A4G23_05244(egtB)
SNR: SNOUR_08405(egtB)
STRD: NI25_03145
SMAL: SMALA_7432
SALJ: SMD11_0805
SLX: SLAV_06110(egtB)
SFK: KY5_7467c
SGE: DWG14_01145(egtB)
SRJ: SRO_0886
SNQ: CP978_05155(egtB)
SKA: CP970_02855(egtB)
KSK: KSE_64560
LMOI: VV02_12405
KFL: Kfla_5162
NDA: Ndas_0638
NAL: B005_3533
STRR: EKD16_07225(egtB)
TCU: Tcur_3640
SRO: Sros_0331
NOW: GBF35_07825(egtB)
FAL: FRAAL6841
NML: Namu_1081
GOB: Gobs_0204
SEN: SACE_3825
SACE: GIY23_10325(egtB)
SACC: EYD13_12500(egtB)
AMD: AMED_4963
AMN: RAM_25265
AMM: AMES_4904
AMZ: B737_4904
AOI: AORI_3753
AJA: AJAP_20390(egtB)
AMYY: YIM_27655(egtB)
AORI: SD37_19250
PDX: Psed_3382
PSEA: WY02_03175
PSEE: FRP1_09620
PSEH: XF36_11005
PAUT: Pdca_32230(egtB)
AMI: Amir_2123
SESP: BN6_30860
KAL: KALB_2951
ACTI: UA75_11530
ACAD: UA74_11445
AHG: AHOG_10780(egtB1)
ALO: CRK56188
SAQ: Sare_2257
MIL: ML5_4984
MTEM: GCE86_13005(egtB)
ASE: ACPL_6426
ACTN: L083_7399
AFS: AFR_38615
ACTS: ACWT_6293
PSUU: Psuf_077000(egtB)
CAI: Caci_8029
SNA: Snas_5169
TBI: Tbis_2650
RXY: Rxyl_0687
RUB: GBA63_13755(egtB) GBA63_15135(egtB)
BSOL: FSW04_08725(egtB)
CWO: Cwoe_4693
SYZ: MYO_12820
SYY: SYNGTS_0280(slr1303)
SYT: SYNGTI_0280(slr1303)
SYS: SYNPCCN_0280(slr1303)
SYQ: SYNPCCP_0280(slr1303)
THEC: FFX45_08975(egtB)
AMR: AM1_5690
OXY: HCG48_02445(egtB)
GLJ: GKIL_4414
AVA: Ava_4280
CALH: IJ00_06485
CTHE: Chro_5483
RCA: Rcas_0125
HAU: Haur_1994
PSL: Psta_4609
RUL: UC8_30590(pkn1_1)
BVO: Pan97_40810(pkn1_4)
FTJ: FTUN_8066
SACI: Sinac_3425
AGV: OJF2_11450(pkn1_2) OJF2_68630(pkn1_6)
KST: KSMBR1_3014(sumf1)
SUS: Acid_3753
ABAC: LuPra_04569(egtB)
BCEL: BcellWH2_03051(pkn1_1)
LFC: LFE_0674
NAX: HC341_03550(egtB)
 » show all
Reference
1  [PMID:20420449]
  Authors
Seebeck FP
  Title
In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.
  Journal
J Am Chem Soc 132:6632-3 (2010)
DOI:10.1021/ja101721e
  Sequence
Reference
2  [PMID:24828577]
  Authors
Pluskal T, Ueno M, Yanagida M
  Title
Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system.
  Journal
PLoS One 9:e97774 (2014)
DOI:10.1371/journal.pone.0097774
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.50
IUBMB Enzyme Nomenclature: 1.14.99.50
ExPASy - ENZYME nomenclature database: 1.14.99.50
BRENDA, the Enzyme Database: 1.14.99.50
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