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Entry
EC 1.14.99.59               Enzyme                                 

Name
tryptamine 4-monooxygenase;
PsiH
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
tryptamine,hydrogen-donor:oxygen oxidoreductase (4-hydroxylating)
Reaction(IUBMB)
tryptamine + reduced acceptor + O2 = 4-hydroxytryptamine + acceptor + H2O [RN:R11912]
Reaction(KEGG)
Substrate
tryptamine [CPD:C00398];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
4-hydroxytryptamine [CPD:C21762];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein isolated from the fungus Psilocybe cubensis. Involved in the biosynthesis of the psychoactive compound psilocybin.
History
EC 1.14.99.59 created 2017
Pathway
ec00901  Indole alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K22434  tryptamine 4-monooxygenase
Reference
1  [PMID:28763571]
  Authors
Fricke J, Blei F, Hoffmeister D
  Title
Enzymatic Synthesis of Psilocybin.
  Journal
Angew Chem Int Ed Engl 56:12352-12355 (2017)
DOI:10.1002/anie.201705489
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.59
IUBMB Enzyme Nomenclature: 1.14.99.59
ExPASy - ENZYME nomenclature database: 1.14.99.59
BRENDA, the Enzyme Database: 1.14.99.59
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