KEGG   ENZYME: 1.15.1.2
Entry
EC 1.15.1.2                 Enzyme                                 

Name
superoxide reductase;
neelaredoxin;
desulfoferrodoxin
Class
Oxidoreductases;
Acting on superoxide as acceptor;
Acting on superoxide as acceptor (only sub-subclass identified to date)
Sysname
rubredoxin:superoxide oxidoreductase
Reaction(IUBMB)
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin [RN:R05743]
Reaction(KEGG)
R05743
Substrate
superoxide [CPD:C00704];
reduced rubredoxin [CPD:C00340];
H+ [CPD:C00080]
Product
H2O2 [CPD:C00027];
oxidized rubredoxin [CPD:C00435]
Comment
The enzyme contains non-heme iron.
History
EC 1.15.1.2 created 2001 as EC 1.18.96.1, transferred 2001 to EC 1.15.1.2
Orthology
K05919  superoxide reductase
Genes
EAL: EAKF1_ch3412c
CFD: CFNIH1_13140
METY: MRY16398_12390(rbo)
KIN: AB182_05565
PDZ: HHA33_08275
EBC: C2U52_15210
SERA: Ser39006_011130
SERQ: CWC46_11125
DDA: Dd703_1404
BGJ: AWC36_00140
FBL: Fbal_1766
METL: U737_11160
TIG: THII_0066
SUA: Saut_1297
SULC: CVO_05270
SULR: B649_06470
CSPF: CSF_1368
CBLA: CBLAS_1215
AELL: AELL_0887
AAQI: AAQM_0781
ASUI: ASUIS_0866
ACLO: ACLO_0854
ALK: ALEK_1048
AMYT: AMYT_0948
AMAR: AMRN_0910
ACAA: ACAN_0960
AMOL: AMOL_0819
APAI: APAC_0773
HBV: ABIV_0649
HEBR: AEBR_0915
PACO: AACT_0982
ARC: ABLL_0958
SDL: Sdel_1185
HYO: NNO_1116
SUN: SUN_1204
GSU: GSU0720
GME: Gmet_2613
GLO: Glov_2591
GBM: Gbem_3292
GEO: Geob_3296
GEM: GM21_0956
GEB: GM18_3374
PCA: Pcar_2347
PPD: Ppro_1133
DVU: DVU3183(rbO)
DVL: Dvul_0204
DVM: DvMF_2481
DDE: Dde_3193
DDS: Ddes_2010
DMA: DMR_17610(rbo)
DGG: DGI_3082(nlr)
DTR: RSDT_0359(dfx)
DFL: DFE_2921
DPI: BN4_11664(dfx)
PPRF: DPRO_2575(dfx)
LIP: LI0273
LIR: LAW_00282
DBA: Dbac_2514
DRT: Dret_0140
DPS: DP1668
DOL: Dole_2870
DML: Dmul_11290(dfx)
DAL: Dalk_2367
DAT: HRM2_42000(dfx)
DTO: TOL2_C17410(dfx)
DOV: DSCO28_52640(dfx)
DWD: DSCW_20160(dfx_1) DSCW_49810(dfx_2)
DALK: DSCA_32000(dfx)
SFU: Sfum_3891
DBR: Deba_2050
MGM: Mmc1_2950
CAC: CA_C2450
CAE: SMB_G2485
CAY: CEA_G2464
CTC: CTC_02454
CBA: CLB_3391
CBH: CLC_3278
CBY: CLM_3769
CBL: CLK_2750
CBB: CLD_1188
CBI: CLJ_B3615
CBF: CLI_3506
CBM: CBF_3487
CBE: Cbei_3348
CBZ: Cbs_3348
CBEI: LF65_03833
CKL: CKL_3781(rbo)
CKR: CKR_3342
CPAS: Clopa_1192
CPAT: CLPA_c12400(dfx)
CPAE: CPAST_c12400(dfx)
CSB: CLSA_c38480(dfx)
CSQ: CSCA_4512
CLD: CLSPO_c34560(dfx)
CTYK: CTK_C26860(dfx)
CCOH: SAMEA4530647_2158(dfx)
AMT: Amet_4653
AOE: Clos_0239
HHW: NCTC503_00627(dfx)
HSC: HVS_15645(dfx)
CCE: Ccel_3474
RUM: CK1_08610
BPB: bpr_I0377(dfx)
BFI: CIY_31980
BHU: bhn_I1019
ROB: CK5_07940
BPRO: PMF13cell1_00460(dfx_1) PMF13cell1_02030(dfx_3)
CSCI: HDCHBGLK_01585(dfx_1)
CSO: CLS_38870
BPRL: CL2_05720
HSD: SD1D_0274
CPRO: CPRO_00250(dfx)
EHL: EHLA_2655
ACEL: acsn021_36620(rbo)
ERT: EUR_17120
CDF: CD630_08270(rbo)
PDC: CDIF630_00946(dsr)
CDC: CD196_0776(rbo)
CDL: CDR20291_0757(rbo)
PDF: CD630DERM_08270(rbo)
EAC: EAL2_c12690(dfx)
PHX: KGNDJEFE_00677(dfx_1)
SLP: Slip_1537
SGY: Sgly_3044
ELM: ELI_3815
AWO: Awo_c14750(rbo)
OVA: OBV_40810(rbo)
BPRM: CL3_01260
TTE: TTE2229
TIT: Thit_2145
MTA: Moth_1285
MTHO: MOTHE_c12680(dfx)
MTHZ: MOTHA_c13540(dfx)
ADG: Adeg_0945
CSC: Csac_2039
ATE: Athe_1492
TTM: Tthe_0254
TSH: Tsac_0814
TACI: TDSAC_0126
TOC: Toce_1860
FMA: FMG_0046
APR: Apre_1362
PED: ING2D1G_1219(sorA)
VPR: Vpar_1127
VRM: 44547418_01196(nlr)
SRI: SELR_07190(dfx)
MHG: MHY_06710
PUF: UFO1_1486
PFT: JBW_02848
AIN: Acin_1207
PFAC: PFJ30894_02271(dfx)
EUC: EC1_18330
AARG: Aargi30884_29570(rbo)
ABSI: A9CBEGH2_01700(rbo)
FIT: Fi14EGH31_27910(rbo)
MGJ: MGM1_1960
AHK: NCTC10172_00138(dfx)
MBJ: KQ51_01851(dfx)
ELE: Elen_1113
GPA: GPA_31640
AEQ: AEQU_1313
APV: Apar_0897
CBAC: JI75_03720
DFO: Dform_00385(dfx)
TTF: THTE_0582
PBU: L21SP3_01534(dfx)
PBP: STSP1_01290(dfx)
PBAS: SMSP2_00801(dfx)
TPW: TPANIC_0823(sorA)
TPP: TPASS_0823(rbo)
TPU: TPADAL_0823(sorA)
TPO: TPAMA_0823(sorA)
TPC: TPECDC2_0823(sorA)
TPG: TPEGAU_0823(sorA)
TPM: TPESAMD_0823(sorA)
TPB: TPFB_0823(sorA)
TDE: TDE1754
TPL: TPCCA_0823(sorA)
TPED: TPE_0071
EMI: Emin_0011
EPO: Epro_1202(sor)
ETI: RSTT_245(sor)
RSD: TGRD_271
TAI: Taci_0007
TLI: Tlie_0048
BACC: BRDCF_p296(sorA)
MBAS: ALGA_3701
CACI: CLOAM1366(dfx)
TTK: TST_0336
TMA: TM0658
TMW: THMA_0673
TMQ: THMB_0673
TMX: THMC_0673
TPT: Tpet_0273
TRQ: TRQ2_0271
TNA: CTN_1928
TNP: Tnap_0454
TLE: Tlet_1498
TME: Tmel_1201
TAF: THA_1590
THER: Y592_06890
FNO: Fnod_0468
PMO: Pmob_1631
MARN: LN42_00750
DTN: DTL3_1841
KOL: Kole_2139
ASAC: ATHSA_0174
CEX: CSE_12390(dfx) CSE_12400
CABY: Cabys_2172
DTU: Dtur_0429
CTHI: THC_1396
BANA: BARAN1_1226(sorA)
MJA: MJ_0741
MMP: MMP1157(rbo)
MMD: GYY_06630
MMAK: MMKA1_13350(dfx)
MMAO: MMOS7_12650(dfx)
MMAD: MMJJ_16880(dfx)
MAE: Maeo_0331
MVO: Mvol_0775
MMG: MTBMA_c11510(rbo)
METC: MTCT_0676
METE: tca_00724(dfx)
MST: Msp_0788(rbo)
MRU: mru_1564(dfx)
MSI: Msm_0262
MEB: Abm4_1180(dfx)
MMIL: sm9_0800(dfx)
MEYE: TL18_06305
MOL: YLM1_1050
METH: MBMB1_0845(rbo)
MFC: BRM9_1007(dfx)
MFI: DSM1535_1665(rbo)
MCUB: MCBB_1262(dfx)
AFU: AF_0344
GAC: GACE_1486
GAH: GAH_01684
MEAR: Mpt1_c02720(sorA)
MARC: AR505_0630
ABI: Aboo_0880
PFU: PF1281
PFI: PFC_05620
PHO: PH1083(PH1083)
PAB: PAB0599
PYN: PNA2_1606
PYS: Py04_1401
TKO: TK0525
TON: TON_0868
TGA: TGAM_1216(sorA)
TSI: TSIB_1894
THE: GQS_00690
THA: TAM4_1892
THM: CL1_1840
TLT: OCC_12431
THS: TES1_0427
TNU: BD01_0679
TEU: TEU_08965
PPAC: PAP_03335
MAC: MA_3737
MMA: MM_0632
MMAC: MSMAC_0678
METM: MSMTP_0741
MHOR: MSHOH_0795
MHU: Mhun_0773
MLA: Mlab_0173
MPI: Mpet_2109
MBN: Mboo_2085
MPL: Mpal_0613
MPD: MCP_0733(sor)
MEZ: Mtc_1945(sor) Mtc_2431(dfx)
RCI: RCIX1592(dfx) RCIX2624(sor)
SMR: Smar_0046
IHO: Igni_1348
IIS: EYM_06985
DKA: DKAM_0429
TAG: Tagg_0590
HBU: Hbut_1161
TPE: Tpen_1830
NEQ: NEQ011
LOKI: Lokiarch_17190(dfx)
PSYT: DSAG12_01108(sorA)
 » show all
Reference
1  [PMID:10514376]
  Authors
Jenney FE Jr, Verhagen MF, Cui X, Adams MW
  Title
Anaerobic microbes: oxygen detoxification without superoxide dismutase.
  Journal
Science 286:306-9 (1999)
DOI:10.1126/science.286.5438.306
  Sequence
[pfu:PF1281]
Reference
2  [PMID:10704199]
  Authors
Yeh AP, Hu Y, Jenney FE Jr, Adams MW, Rees DC.
  Title
Structures of the superoxide reductase from Pyrococcus furiosus in the oxidized and reduced states.
  Journal
Biochemistry 39:2499-508 (2000)
DOI:10.1021/bi992428k
  Sequence
[pfu:PF1281]
Reference
3  [PMID:10617593]
  Authors
Lombard M, Fontecave M, Touati D, Niviere V
  Title
Reaction of the desulfoferrodoxin from Desulfoarculus baarsii with superoxide anion. Evidence for a superoxide reductase activity.
  Journal
J Biol Chem 275:115-21 (2000)
DOI:10.1074/jbc.275.1.115
  Sequence
[dbr:Deba_2050]
Reference
4  [PMID:11069658]
  Authors
Abreu IA, Saraiva LM, Carita J, Huber H, Stetter KO, Cabelli D, Teixeira M.
  Title
Oxygen detoxification in the strict anaerobic archaeon Archaeoglobus fulgidus: superoxide scavenging by neelaredoxin.
  Journal
Mol Microbiol 38:322-34 (2000)
DOI:10.1046/j.1365-2958.2000.02121.x
Other DBs
ExplorEnz - The Enzyme Database: 1.15.1.2
IUBMB Enzyme Nomenclature: 1.15.1.2
ExPASy - ENZYME nomenclature database: 1.15.1.2
BRENDA, the Enzyme Database: 1.15.1.2
CAS: 250679-67-5
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