Oxidoreductases;
Acting on CH or CH2 groups;
With a disulfide as acceptor
BRITE hierarchy

3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase

3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol = 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol [RN:R03512]

R03512;
(other) R05830
Reaction

3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone [CPD:C02785];
oxidized dithiothreitol [CPD:C01119]

Vitamin K 2,3-epoxide is reduced to 3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithiothreitol, which is oxidized to a disulfide. Not inhibited by warfarin [cf. EC 1.17.4.4, vitamin-K-epoxide reductase (warfarin-sensitive)].

EC 1.17.4.5 created 1989 as EC 1.1.4.2, transferred 2014 to EC 1.17.4.5

1  [PMID:3857611]

Mukharji I, Silverman RB.

Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone.

Proc Natl Acad Sci U S A 82:2713-7 (1985)
DOI:10.1073/pnas.82.9.2713