Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy

5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate:NAD+ 5-oxidoreductase

5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + NAD+ + H2O = 3-hydroxy-2-methylpyridine-4,5-dicarboxylate + NADH + H+ [RN:R04524]

R04524
Reaction

5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate [CPD:C06050];
NAD+ [CPD:C00003];
H2O [CPD:C00001]

The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B6).

EC 1.2.1.100 created 2018

1  [PMID:3533936]

Lee YC, Nelson MJ, Snell EE.

Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase.

J Biol Chem 261:15106-11 (1986)

2  [PMID:19218190]

Yokochi N, Yoshikane Y, Matsumoto S, Fujisawa M, Ohnishi K, Yagi T

Gene identification and characterization of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD+-dependent dismutase.

J Biochem 145:493-503 (2009)
DOI:10.1093/jb/mvp007

[mlo:mlr6793]

3  [PMID:25446130]

Mugo AN, Kobayashi J, Mikami B, Yoshikane Y, Yagi T, Ohnishi K

Crystal structure of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD(+)-dependent dismutase from Mesorhizobium loti.

Biochem Biophys Res Commun 456:35-40 (2015)
DOI:10.1016/j.bbrc.2014.11.028

[mlo:mlr6793]