KEGG   ENZYME: 1.2.1.103
Entry
EC 1.2.1.103                Enzyme                                 

Name
[amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase;
lysY (gene name)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
[amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine]:NADP+ 5-oxidoreductase (phosphorylating)
Reaction(IUBMB)
an [amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine] + phosphate + NADP+ = an [amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-phosphooxy-5-oxopentyl)-L-glutamine] + NADPH + H+ [RN:R09777]
Reaction(KEGG)
R09777
Substrate
[amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine];
phosphate [CPD:C00009];
NADP+ [CPD:C00006]
Product
[amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-phosphooxy-5-oxopentyl)-L-glutamine];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme participates in an L-lysine biosynthesis in certain species of archaea and bacteria.
History
EC 1.2.1.103 created 2019
Pathway
ec00300  Lysine biosynthesis
ec01100  Metabolic pathways
Orthology
K05829  LysW-gamma-L-alpha-aminoadipyl-6-phosphate/LysW-L-glutamyl-5-phosphate reductase
Genes
ENF: AKI40_3666(argC1)
CARI: FNU76_03415(argC)
ADE: Adeh_0171
ACP: A2cp1_0191
AFW: Anae109_0180
ANK: AnaeK_0180
MXA: MXAN_5110(argC)
MSD: MYSTI_01367 MYSTI_05599
MYM: A176_001775
CCX: COCOR_02066(argC) COCOR_02384(argC1)
CCRO: CMC5_013340(argC)
HOH: Hoch_4934
PMW: B2K_22475
PSWU: SY83_08900
SGR: SGR_3479
SFA: Sfla_0120
STRP: F750_6904
SFI: SFUL_3351
SCI: B446_19850(lysY)
SPRI: SPRI_3643
SRW: TUE45_06897(argC_2)
SLAU: SLA_3044
SALJ: SMD11_6707(lysY)
SESP: BN6_56700
ASE: ACPL_7490(argC)
ACTS: ACWT_7360
PLK: CIK06_18385(argC)
CAI: Caci_6304
RCA: Rcas_3468
CAU: Caur_0335
CAG: Cagg_3596
HAU: Haur_3307
TRO: trd_1518(argC)
STI: Sthe_0216
ATM: ANT_12400(argC)
CAP: CLDAP_41080(argC)
DRA: DR_0963(argC)
DGE: Dgeo_0685
DGO: DGo_CA1602(argC)
DFC: DFI_07605
DGA: DEGR_14640(argC1)
TRA: Trad_1395
TTH: TT_C1542
TTJ: TTHA1904(argC)
TSC: TSC_c01930(argC1)
TAQ: TO73_0099
TBC: A0O31_00869(argC_1)
MRB: Mrub_2723
MRE: K649_08920(argC)
TTR: Tter_0319
TAI: Taci_0448
TLI: Tlie_1470
RMR: Rmar_0948
MRO: MROS_0164
CABY: Cabys_3149(argC)
PTO: PTO1472
FAI: FAD_0505(lysY)
CDIV: CPM_0548
PFU: PF1683
PFI: PFC_10190(argC)
PHO: PH1720(PH1720)
PAB: PAB0291(argC)
PYN: PNA2_0328
PYS: Py04_1635
TKO: TK0277
THS: TES1_0508
HHB: Hhub_3649(argC)
HJE: HacjB3_00985(argC)
HALH: HTSR_0665(argC)
HHSR: HSR6_0691(argC)
HSU: HLASF_2138(argC)
HSF: HLASA_2172(argC)
HMA: rrnAC2678(argC)
HHI: HAH_3082(argC)
NPH: NP_5260A(argC)
NMO: Nmlp_1242(argC)
HUT: Huta_1501
HTI: HTIA_1540
HMU: Hmuk_0773
HALL: LC1Hm_3289(argC)
HWA: HQ_3715A(argC)
HWC: Hqrw_4130(argC)
HVO: HVO_0045(argC)
HME: HFX_0045(argC)
HLA: Hlac_2615
HDF: AArcSl_0042(argC)
HTU: Htur_0327
NMG: Nmag_1760(argC)
NAT: NJ7G_0262
SALI: L593_07890(argC)
APE: APE_1462(lysY)
ACJ: ACAM_0921
IHO: Igni_0728
IIS: EYM_02375
IAG: Igag_1754
STO: STK_01950(argC_lysY)
SSO: SSO0155(argC)
SOL: Ssol_1133
SSOA: SULA_1169
SSOL: SULB_1170
SSOF: SULC_1168
SAI: Saci_0750(argC)
SACN: SacN8_03645(argC)
SACR: SacRon12I_03630(argC)
SID: M164_1990
SII: LD85_2245
SIH: SiH_1928
SIR: SiRe_1855
SIC: SiL_1837
MSE: Msed_0164
MCN: Mcup_1909
AHO: Ahos_0883
STEP: IC006_1902
PAI: PAE2881
PIS: Pisl_0276
PCL: Pcal_0373
PAS: Pars_0966
PYR: P186_1636
POG: Pogu_1380
TNE: Tneu_1837
CMA: Cmaq_1301
TTN: TTX_0120(lysY_argC)
TUZ: TUZN_1285
VDI: Vdis_0193
VMO: VMUT_1533
NMR: Nmar_1289
NIR: NSED_07155(argC)
NKR: NKOR_07275(argC)
NID: NPIRD3C_0835(argC)
NIN: NADRNF5_0667(argC)
NCT: NMSP_0399
NGA: Ngar_c29960(argC)
NVN: NVIE_016490(argC)
NEV: NTE_00734
TAA: NMY3_02222(argC2)
NFN: NFRAN_2984(lysY)
NCV: NCAV_1251(lysY)
NBV: T478_1044(argC)
NDV: NDEV_1624(argC)
KCR: Kcr_0809
BARB: AOA66_0020
CCAI: NAS2_0267
 » show all
Reference
1  [PMID:10613839]
  Authors
Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H
  Title
A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis.
  Journal
Genome Res 9:1175-83 (1999)
DOI:10.1101/gr.9.12.1175
Reference
2  [PMID:19620981]
  Authors
Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M.
  Title
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
  Journal
Nat Chem Biol 5:673-9 (2009)
DOI:10.1038/nchembio.198
  Sequence
[tth:TT_C1542]
Reference
3  [PMID:26966182]
  Authors
Shimizu T, Tomita T, Kuzuyama T, Nishiyama M
  Title
Crystal Structure of the LysY.LysW Complex from Thermus thermophilus.
  Journal
J Biol Chem 291:9948-59 (2016)
DOI:10.1074/jbc.M115.707034
  Sequence
[tth:TT_C1542]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.103
IUBMB Enzyme Nomenclature: 1.2.1.103
ExPASy - ENZYME nomenclature database: 1.2.1.103
BRENDA, the Enzyme Database: 1.2.1.103
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