| Entry |
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| Name |
2-oxoisovalerate dehydrogenase (acylating);
2-oxoisovalerate dehydrogenase;
alpha-ketoisovalerate dehydrogenase
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| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)
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| Reaction(IUBMB) |
3-methyl-2-oxobutanoate + CoA + NAD+ = 2-methylpropanoyl-CoA + CO2 + NADH [RN: R01210]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxopentanoate.
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| History |
EC 1.2.1.25 created 1972
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| Reference |
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| Authors |
Namba Y, Yoshizawa K, Ejima A, Hayashi T, Kaneda T. |
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| Title |
Coenzyme A- and nicotinamide adenine dinucleotide-dependent branched chain alpha-keto acid dehydrogenase. I. Purification and properties of the enzyme from Bacillus subtilis. |
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| Journal |
J Biol Chem 244:4437-47 (1969) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.2.1.25 |
| ExPASy - ENZYME nomenclature database: | 1.2.1.25 |
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| LinkDB |
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