| Entry |
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| Name |
2-oxoaldehyde dehydrogenase (NADP+);
alpha-ketoaldehyde dehydrogenase;
methylglyoxal dehydrogenase;
NADP+-linked alpha-ketoaldehyde dehydrogenase;
2-ketoaldehyde dehydrogenase;
NADP+-dependent alpha-ketoaldehyde dehydrogenase
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| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
2-oxoaldehyde:NADP+ 2-oxidoreductase
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| Reaction(IUBMB) |
a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo carboxylate + NADPH + H+ [RN: R01338]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Not identical with EC 1.2.1.23 2-oxoaldehyde dehydrogenase (NAD+).
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| History |
EC 1.2.1.49 created 1986
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| Pathway |
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| Reference |
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| Authors |
Ray M, Ray S. |
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| Title |
On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase. |
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| Journal |
J Biol Chem 257:10571-4 (1982) |
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| Reference |
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| Authors |
Ray S, Ray M. |
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| Title |
Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate. |
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| Journal |
J Biol Chem 257:10566-70 (1982) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.2.1.49 |
| ExPASy - ENZYME nomenclature database: | 1.2.1.49 |
| CAS: | 83588-97-0 97162-76-0 |
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| LinkDB |
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