| Entry |
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| Name |
sulfoacetaldehyde dehydrogenase;
SafD
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| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
2-sulfoacetaldehyde:NAD+ oxidoreductase
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| Reaction(IUBMB) |
2-sulfoacetaldehyde + H2O + NAD+ = sulfoacetate + NADH + 2 H+ [RN: R06980]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
This reaction is part of a bacterial pathway that can utilize the amino group of taurine as a sole source of nitrogen for growth. At physiological concentrations, NAD+ cannot be replaced by NADP+. The enzyme is specific for sulfoacetaldehyde, as formaldehyde, acetaldehyde, betaine aldehyde, propanal, glyceraldehyde, phosphonoacetaldehyde, glyoxylate, glycolaldehyde and 2-oxobutyrate are not substrates.
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| History |
EC 1.2.1.73 created 2008
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| Pathway |
| ec00430 | Taurine and hypotaurine metabolism |
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| Orthology |
| K19699 | sulfoacetaldehyde dehydrogenase |
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| Reference |
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| Authors |
Krejcik Z, Denger K, Weinitschke S, Hollemeyer K, Paces V, Cook AM, Smits TH |
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| Title |
Sulfoacetate released during the assimilation of taurine-nitrogen by Neptuniibacter caesariensis: purification of sulfoacetaldehyde dehydrogenase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.2.1.73 |
| ExPASy - ENZYME nomenclature database: | 1.2.1.73 |
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| LinkDB |
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