| Entry |
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| Name |
D-glyceraldehyde dehydrogenase (NADP+);
glyceraldehyde dehydrogenase;
GADH
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| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
D-glyceraldehyde:NADP+ oxidoreductase
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| Reaction(IUBMB) |
D-glyceraldehyde + NADP+ + H2O = D-glycerate + NADPH + H+ [RN: R10615]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme from the archaea Thermoplasma acidophilum and Picrophilus torridus is involved in the non-phosphorylative Entner-Doudoroff pathway. cf. EC 1.2.99.8, glyceraldehyde dehydrogenase (FAD-containing).
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| History |
EC 1.2.1.89 created 2014
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K18128 | D-glyceraldehyde dehydrogenase (NADP+) |
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| Genes |
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| Reference |
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| Authors |
Jung JH, Lee SB |
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| Title |
Identification and characterization of Thermoplasma acidophilum glyceraldehyde dehydrogenase: a new class of NADP+-specific aldehyde dehydrogenase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Reher M, Schonheit P |
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| Title |
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.2.1.89 |
| ExPASy - ENZYME nomenclature database: | 1.2.1.89 |
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| LinkDB |
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