KEGG   ENZYME: 1.2.1.94
Entry
EC 1.2.1.94                 Enzyme                                 

Name
farnesal dehydrogenase;
AaALDH3
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
farnesal:NAD+ oxidoreductase
Reaction(IUBMB)
(2E,6E)-farnesal + NAD+ + H2O = (2E,6E)-farnesoate + NADH + 2 H+
Substrate
(2E,6E)-farnesal [CPD:C03461];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
(2E,6E)-farnesoate [CPD:C16502];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Invoved in juvenile hormone production in insects. The enzyme was described from the corpora allata of Drosophila melanogaster (fruit fly), Manduca sexta (tobacco hornworm) and Aedes aegypti (dengue mosquito).
History
EC 1.2.1.94 created 2015
Reference
1  [PMID:4631837]
  Authors
Madhavan K, Conscience-Egli M, Sieber F, Ursprung H
  Title
Farnesol metabolism in Drosophila melanogaster: ontogeny and tissue distribution  of octanol dehydrogenase and aldehyde oxidase.
  Journal
J Insect Physiol 19:235-41 (1973)
DOI:10.1016/0022-1910(73)90236-9
Reference
2  [PMID:6366103]
  Authors
Baker FC, Mauchamp B, Tsai LW, Schooley DA
  Title
Farnesol and farnesal dehydrogenase(s) in corpora allata of the tobacco hornworm  moth, Manduca sexta.
  Journal
J Lipid Res 24:1586-94 (1983)
Reference
3  [PMID:23639754]
  Authors
Rivera-Perez C, Nouzova M, Clifton ME, Garcia EM, LeBlanc E, Noriega FG
  Title
Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes.
  Journal
Insect Biochem Mol Biol 43:675-82 (2013)
DOI:10.1016/j.ibmb.2013.04.002
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.94
IUBMB Enzyme Nomenclature: 1.2.1.94
ExPASy - ENZYME nomenclature database: 1.2.1.94
BRENDA, the Enzyme Database: 1.2.1.94
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