Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With a disulfide as acceptor
BRITE hierarchy

pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)

pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2 [RN:R01699]

R01699;
(other) R00014 R03270
Reaction

pyruvate [CPD:C00022];
[dihydrolipoyllysine-residue acetyltransferase] lipoyllysine [CPD:C15972]

Contains thiamine diphosphate. It is a component (in multiple copies) of the multienzyme pyruvate dehydrogenase complex in which it is bound to a core of molecules of EC 2.3.1.12, dihydrolipoyllysine-residue acetyltransferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12.

EC 1.2.4.1 created 1961, modified 2003