EC                  Enzyme                                 

aerobic carbon monoxide dehydrogenase;
coxSML (gene names);
molybdoenzyme carbon monoxide dehydrogenase
Acting on the aldehyde or oxo group of donors;
With a quinone or similar compound as acceptor
BRITE hierarchy
carbon-monoxide:quinone oxidoreductase
CO + a quinone + H2O = CO2 + a quinol [RN:R11168]
CO [CPD:C00237];
quinone [CPD:C15602];
H2O [CPD:C00001]
CO2 [CPD:C00011];
quinol [CPD:C15603]
This enzyme, found in carboxydotrophic bacteria, catalyses the oxidation of CO to CO2 under aerobic conditions. The enzyme contains a binuclear Mo-Cu cluster in which the copper is ligated to a molybdopterin center via a sulfur bridge. The enzyme also contains two [2Fe-2S] clusters and FAD, and belongs to the xanthine oxidoreductase family. The CO2 that is produced is assimilated by the Calvin-Benson-Basham cycle, while the electrons are transferred to a quinone via the FAD site, and continue through the electron transfer chain to a dioxygen terminal acceptor [5]. cf. EC, anaerobic carbon monoxide dehydrogenase.
EC created 2016
K03518  aerobic carbon-monoxide dehydrogenase small subunit
K03519  aerobic carbon-monoxide dehydrogenase medium subunit
K03520  aerobic carbon-monoxide dehydrogenase large subunit
OTW: 112244193
KOX: KOX_23335
KOE: A225_3555
KOY: J415_14310
KOM: HR38_21635
KOK: KONIH1_17375
KOC: AB185_18530
EAE: EAE_17615
EAR: CCG30369
CRO: ROD_33891
RTG: NCTC13098_02435(ndhS)
SPLY: Q5A_021395(cdhA) Q5A_021400(cdhC) Q5A_021405(cdhB)
SFJ: SAMEA4384070_4134(hcrC_2)
MINT: C7M51_04199(ndhS)
MTHI: C7M52_02857(ndhS)
PPR: PBPRA1940(RB0790)
SHL: Shal_0652
GAI: IMCC3135_02055(cutM) IMCC3135_02060(ndhS)
RSC: RCFBP_11878(coxS) RCFBP_11879(coxL) RCFBP_11880(coxM)
RSL: RPSI07_1900(coxS) RPSI07_1901(coxL) RPSI07_1902(coxM)
RSN: RSPO_c01882(coxS) RSPO_c01884(coxL) RSPO_c01885(coxM)
RSM: CMR15_20676(coxM) CMR15_20677(coxL) CMR15_20678(coxS)
RSY: RSUY_19090(cutM) RSUY_19100(cutL) RSUY_19110(coxS)
REH: H16_A0437(coxM1) H16_A0438(coxL1) H16_A0439(coxS1) H16_A1724(h16_A1724) H16_A3369(h16_A3369) H16_A3370(coxS5) H16_B0744(hcrB) H16_B0745(hcrC) H16_B0815(qorL2) H16_B0816(h16_B0816) H16_B0817(h16_B0817)
CNC: CNE_1c04580(coxM) CNE_1c04590(coxL1) CNE_1c04600(coxS1) CNE_2c06910(hcrB) CNE_2c06920(hcrC) CNE_2c07630(cutL) CNE_2c07640(cutM) CNE_2c07650(cutS)
RME: Rmet_0363(coxM) Rmet_0364(coxL) Rmet_0365(coxS)
CTI: RALTA_A0379(cooxM) RALTA_A0380(coxL) RALTA_A0381(coxS) RALTA_A2828(xdhB1) RALTA_A2829(xdhC1) RALTA_B0581(hbaD) RALTA_B0582(hbaB)
CGD: CR3_0354(coxM) CR3_0355(coxL) CR3_0356(coxS) CR3_2984(coxL) CR3_2985(coxM) CR3_2986(coxS)
BAV: BAV1575(cutS) BAV1576(cutM) BAV1577(cutL) BAV2736(cutL) BAV2738(cutM)
AFQ: AFA_15090(picA3) AFA_15095(picA2) AFA_15100(picA1)
HPSE: HPF_04395(cutL1) HPF_04400(cutS) HPF_04405(cutM) HPF_17415(coxS) HPF_17420(cutL2) HPF_17425(coxM)
MMS: mma_0774(cutL) mma_0775(cutM) mma_0776
RGE: RGE_39240(coxS) RGE_39250(coxL) RGE_39260(coxM)
TCL: Tchl_1903
GME: Gmet_2134(pcmR) Gmet_2135(pcmS)
GLO: Glov_2414
GEO: Geob_0107(pcmS) Geob_0108(pcmR)
DMA: DMR_19370(xdhC)
DGG: DGI_2469
DAS: Daes_3248
DPI: BN4_11185
PPRF: DPRO_1024(cutC)
DPS: DP2532(coxS)
DAT: HRM2_38000(coxS)
DTO: TOL2_C15820(hcrC) TOL2_C15830(hcrB) TOL2_C16060(hcrC2) TOL2_C41670(hcrB3) TOL2_C41680(hcrC3)
SCL: sce5894
SFU: Sfum_2011
DBR: Deba_2625
AMIH: CO731_03083(cutS) CO731_03084(cutL_1) CO731_03085(cutM) CO731_04394(cutL_2)
ARA: Arad_4266(xdhA) Arad_4267 Arad_4268(xdhA)
AVI: Avi_5434(xdhA)
RLE: pRL80023(cutM) pRL80024(cutC)
RGA: RGR602_CH03767(coxM-1) RGR602_CH03768(coxL-1) RGR602_CH03769(coxS-1) RGR602_PA00035(coxL-2) RGR602_PA00037(coxS-2)
PLEO: OHA_1_02482(cutM) OHA_1_02483(cutL_1) OHA_1_02484(cutS) OHA_1_04365(cutL_2)
HDI: HDIA_0356(cdhB_1) HDIA_0357(cdhC) HDIA_0358(cdhA_1) HDIA_0630(cutS_1) HDIA_0631(cutL_1) HDIA_0632(cutM) HDIA_2733(cutL_2) HDIA_3416(cdhA_2) HDIA_3417(cdhB_2) HDIA_3418(cutS_2)
SIL: SPO1518(coxS-1) SPO1519(coxL-1) SPO1520 SPO2397(coxL-2) SPO2398(coxS-2) SPO2399(coxM) SPO2881 SPO3019
RUT: FIU92_02340(coxM1) FIU92_02345(coxS1) FIU92_02350(coxL) FIU92_03885(cutL1) FIU92_12525(cutS) FIU92_19420(coxS2) FIU92_19425(cutL2) FIU92_19430(coxM3) FIU92_21390(coxS3) FIU92_21395(cutL3) FIU92_21400(cutM)
RSP: RSP_2876 RSP_2877(coxL) RSP_2878(coxS)
RDE: RD1_1758 RD1_2972(coxM) RD1_2973(coxL) RD1_2974(coxS)
DSH: Dshi_1040 Dshi_1210(coxM) Dshi_1211(coxS) Dshi_1212(coxL2) Dshi_2086(coxL3) Dshi_2658 Dshi_2659(coxL1) Dshi_2660 Dshi_4200(coxM) Dshi_4201(coxS) Dshi_4202(coxL)
PSF: PSE_1024(coxS) PSE_1025(coxL) PSE_1027(coxM) PSE_4140
OTM: OSB_14940(coxS_1) OSB_14950(cutL) OSB_14960(coxM_1) OSB_29600(coxL) OSB_29610(coxS_2) OSB_29620(coxM_2)
LABT: FIU93_15555(cutL1) FIU93_19880(cutS2) FIU93_19885(cutL2) FIU93_19890(cutM) FIU93_20275(coxM) FIU93_20280(coxS) FIU93_20285(coxL) FIU93_27560(cdhA) FIU93_27565(cdhC) FIU93_27570(kdhA)
RID: RIdsm_02424(coxS) RIdsm_02425(cutL) RIdsm_02426(cutM) RIdsm_03762(coxL) RIdsm_04066(cutS)
ROH: FIU89_11795(cutM1) FIU89_11800(cutL) FIU89_11810(coxS) FIU89_14355(ndhS2)
MARU: FIU81_10175(coxL) FIU81_10515(coxM) FIU81_10520(cutL) FIU81_10525(coxS2)
ROT: FIV09_03175(cutL1) FIV09_08295(kdhA) FIV09_08300(cdhC) FIV09_08305(cdhA) FIV09_10550(coxM1) FIV09_10555(cutL2) FIV09_10560(coxS1) FIV09_18870(coxM3) FIV09_18875(coxS2) FIV09_18880(coxL)
ANH: A6F65_02142(kdhA) A6F65_02143(cutL) A6F65_02144(coxS)
KSC: CD178_01483(cdhA) CD178_01484(cdhB)
RCE: RC1_1074(coxM) RC1_1075(coxL) RC1_1076(coxS)
MAGX: XM1_1619 XM1_2479(xdhA) XM1_2779(cutC) XM1_2780
AZL: AZL_015320(xdhB) AZL_c02250 AZL_c02260(xdhB) AZL_c02270(cutM)
ALI: AZOLI_1316(coxL2) AZOLI_p30107(coxS) AZOLI_p30108(coxL1) AZOLI_p30109(coxM)
TMO: TMO_0651(cutL) TMO_1174(cutM) TMO_1175(cutL) TMO_1176(cutS) TMO_2155(coxL)
AFR: AFE_0776
BSR: I33_3350(pucE)
BSL: A7A1_2463
BSH: BSU6051_32470(pucE)
BSUT: BSUB_03466(pucE)
BSUL: BSUA_03466(pucE)
BSUS: Q433_17770
BSS: BSUW23_15845(pucE)
BST: GYO_3545(pucE)
BSO: BSNT_09731(pucE)
BSQ: B657_32470(pucE)
BAQ: BACAU_3715(pucE)
BYA: BANAU_3884(pucE)
BAMP: B938_18990
BAML: BAM5036_3621(ndhS)
BAMA: RBAU_3829(nicA)
BAMN: BASU_3611(nicA)
BAMB: BAPNAU_3893(pucE)
BAMT: AJ82_20880
BAMY: V529_39680
BMP: NG74_03878(nicA)
BAO: BAMF_3826(RBAM_037010)
BQL: LL3_04148
BQY: MUS_4393
BAMI: KSO_000590
BAMC: U471_38610
BAMF: U722_19705
BMQ: BMQ_2567(pucE)
BMD: BMD_2556(pucE)
BMEG: BG04_5020
BACP: SB24_10255
BACB: OY17_02180
BACY: QF06_14555
BACL: BS34A_35430(pucE)
BALM: BsLM_3243
BEO: BEH_09830
BGY: BGLY_3831
BKW: BkAM31D_03140(pucE)
BBEV: BBEV_2694(pucE)
GGH: GHH_c03990(pucE1) GHH_c21840(pucE2)
GEA: GARCT_00425(ndhS) GARCT_02057(pucE)
AAMY: GFC30_798
BSE: Bsel_0577
PSWU: SY83_16730
CBO: CBO0260(xdhC1)
CBA: CLB_0304
CBH: CLC_0319
CBL: CLK_3442
CBB: CLD_0498
CBT: CLH_3081
CBF: CLI_0333
CBM: CBF_0301
CBE: Cbei_1985
CBZ: Cbs_1985
CBEI: LF65_02154
CPAT: CLPA_c03330(ndhS2)
CPAE: CPAST_c03330(ndhS2)
CSB: CLSA_c18360(hcrC)
CTYK: CTK_C07950
RUM: CK1_05420
FPR: FP2_06970
FPA: FPR_30810
RIX: RO1_14790
RIM: ROI_22700
ROB: CK5_31120
BPRL: CL2_20270
EHL: EHLA_0953
ERT: EUR_06050
ERA: ERE_13450
CDF: CD630_20810(xdhC1) CD630_20880(xdhC2) CD630_21000(xdhC)
PDC: CDIF630_02304(xdhC1) CDIF630_02311(xdhC2) CDIF630_02323(xdhC3)
CDC: CD196_1945(xdhC) CD196_1952(cutS) CD196_1964
EAC: EAL2_808p07310(pucE)
PTH: PTH_1539(CoxS) PTH_1540(CoxM) PTH_1579(CoxS)
AWO: Awo_c11860(xdhC)
OVA: OBV_12080 OBV_17280(xdhC)
BPRS: CK3_12390
CBAR: PATL70BA_2720(xdhC) PATL70BA_2727(pucE)
CHY: CHY_0691
MTA: Moth_1961
MTHO: MOTHE_c20000(ndhS2)
MTHZ: MOTHA_c20790(ndhS2)
FMA: FMG_0505
VPR: Vpar_0285
VRM: 44547418_00299(hcrC)
VDN: NCTC11831_00271(hcrC)
MED: MELS_0172
MHG: MHY_25210
PUF: UFO1_2036
PFT: JBW_02542
STED: SPTER_35980(pucE) SPTER_36120(ndhS) SPTER_39230(cutS) SPTER_39240(ndhF_2)
EUC: EC1_03630
MCQ: BN44_10414(cutL) BN44_10415(coxS) BN44_10416(CoxM)
MCV: BN43_10406(cutL) BN43_10407(coxS) BN43_10408(CoxM)
MCX: BN42_20100(cutL) BN42_20101(coxS) BN42_20102(CoxM)
MCZ: BN45_10415(cutL) BN45_10416(coxS) BN45_10417(CoxM)
MUL: MUL_0115(coxL) MUL_0116(coxS) MUL_0587(coxM_2) MUL_0588(coxL_2)
MMI: MMAR_0621(coxS_3) MMAR_0622(coxM_3) MMAR_0623(coxL_3) MMAR_0655(coxM) MMAR_0656(coxS) MMAR_0657(coxL)
MMAE: MMARE11_05800(coxS_3) MMARE11_05810(coxM_3) MMARE11_05820(coxL_3) MMARE11_06050(coxM) MMARE11_06060(coxS) MMARE11_06070(coxL)
MLI: MULP_00617(coxS_3) MULP_00618(coxM_3) MULP_00619(coxL_3) MULP_00646(coxM) MULP_00647(coxS) MULP_00648(coxL)
MTHN: 4412656_00449(cutM_1) 4412656_00450(coxS_1) 4412656_00451(cutL_1) 4412656_04003(cutL_2) 4412656_04005(cutM_2) 4412656_04006(coxS_2)
MHAS: MHAS_03670(cdhA) MHAS_03672(kdhA) MHAS_03673(coxS)
RHB: NY08_3485
RFA: A3L23_03315(kdhA_1) A3L23_03316(cdhA_1) A3L23_03317(cdhC_1) A3L23_03482(cdhA_2) A3L23_03483(cdhC_2) A3L23_03484(kdhA_2)
RHS: A3Q41_00015(cdhC_1) A3Q41_00016(cdhA_1) A3Q41_00017(kdhA_1) A3Q41_04771(kdhA_2) A3Q41_04772(cdhC_2) A3Q41_04773(cdhA_2) A3Q41_04902(cdhC_3)
RRT: 4535765_01785(cutM_1) 4535765_01786(cutS_1) 4535765_01787(cutL_1) 4535765_04468(cutL_2) 4535765_04469(coxS) 4535765_04470(cutM_2) 4535765_04774(cutS_2) 4535765_04775(cutL_3) 4535765_04776(cutM_3)
SCO: SCO6171(SC6C5.07)
SGR: SGR_1354
SGB: WQO_28510
SCT: SCAT_4759
SFA: Sfla_1090
SVE: SVEN_5953
STRP: F750_5751
SFI: SFUL_6109
SRW: TUE45_06801(ndhS_2)
SLE: sle_15060(sle_15060)
STRD: NI25_08520
SLAU: SLA_6052
SALF: SMD44_06773(coxS)
SALJ: SMD11_1460(coxS)
SLX: SLAV_09445(ndhS) SLAV_30315(coxS) SLAV_30320(cutL) SLAV_30325(cutM)
SFK: KY5_6396
SGE: DWG14_01894(ndhS_1)
ARX: ARZXY2_2002(coxS)
AAU: AAur_1922
BCV: Bcav_1675
NDK: I601_0512(cutM) I601_0513(cutL) I601_0514(cutS) I601_1312(cdhC) I601_1313(cdhA)
NDA: Ndas_2225
NAL: B005_4597
STRR: EKD16_02770(cutS1) EKD16_02775(cutL) EKD16_02780(cutM) EKD16_13740(coxS) EKD16_19200(cdhA) EKD16_19205(kdhB) EKD16_19210(kdhA)
BSD: BLASA_0145(coxL3) BLASA_0146(coxS3) BLASA_0147(coxM3) BLASA_1355(coxS1) BLASA_1356(coxM1) BLASA_1453(coxL4) BLASA_1454(coxM4) BLASA_1461(coxM5) BLASA_1462(coxS5) BLASA_4798(coxM2) BLASA_4799(coxL2) BLASA_4800(coxS2)
SACC: EYD13_02855(cutM1) EYD13_02860(cutS1) EYD13_02865(cutL1) EYD13_07115(cutS2) EYD13_07120(cutL2) EYD13_07125(cutM2) EYD13_10445(cutL3) EYD13_10450(coxS) EYD13_10455(cutM3) EYD13_13305(cdhA) EYD13_13310(cdhC)
AMD: AMED_1870(coxS) AMED_1871 AMED_1872(cutM) AMED_1920(coxS) AMED_4584(coxS) AMED_5244(cutM) AMED_5245(coxS)
AMM: AMES_1856(coxS) AMES_1857 AMES_1858(cutM) AMES_1905(coxS) AMES_4529(coxS) AMES_5181(cutM) AMES_5182(coxS) AMES_5183(cutL)
AMZ: B737_1857(coxS) B737_1858 B737_1859(cutM) B737_1906(coxS) B737_4529(coxS) B737_5181(cutM) B737_5182(coxS) B737_5183(cutL)
AOI: AORI_4770(coxS) AORI_4771(cutL) AORI_4772(cutM) AORI_5955(coxS) AORI_6004(cutM) AORI_6005 AORI_6006(coxS) AORI_6478 AORI_6479(cutM) AORI_6480(coxS)
AMYY: YIM_10470(cutS1) YIM_10475(cutL) YIM_10480(cutM) YIM_11195(ndhS1) YIM_19275(ndhS2) YIM_29105(cdhA) YIM_29110(kdhA)
KAL: KALB_4509
SNA: Snas_2540
PCAT: Pcatena_11860(xdhC1)
PSL: Psta_3686
PLH: VT85_11495(ndhS)
GMR: GmarT_13180(cutS)
PBOR: BSF38_03373(ndhS)
TDE: TDE0727
TPED: TPE_1115
BHY: BHWA1_00061(coxS)
BRM: Bmur_2647
BPW: WESB_2039
BIP: Bint_1940(coxS)
ABAC: LuPra_04499(cutS_1) LuPra_04500(cutL) LuPra_04501(cutM)
SBR: SY1_20970
FAE: FAES_4895(cutM) FAES_4896(coxL) FAES_4897
HTH: HTH_0386(coxM) HTH_0387(coxL) HTH_0388(coxS)
KOL: Kole_2076
MINF: MESINF_2575(xdhC) MESINF_2772(ndhS) MESINF_2776(xdhC)
HMA: pNG7245(iorA) pNG7247(cutC)
HHI: HAH_5306(cutC) HAH_5310(iorA)
NMO: Nmlp_3629(coxM) Nmlp_3631(coxS)
HWA: HQ_1942A(coxM) HQ_1943A(coxS)
HWC: Hqrw_2105(coxM1) Hqrw_2106(coxS1) Hqrw_2218(coxS2) Hqrw_2219(coxL2) Hqrw_2220(coxM2)
HVO: HVO_B0308(coxS) HVO_B0309(coxL) HVO_B0310(coxM)
HDF: AArcSl_2501(coxS) AArcSl_2504(coxS2)
SSO: SSO2150(cutA-3) SSO2433(cutC-1) SSO2434(cutB-1)
TTN: TTX_0326(coxL_cutL) TTX_0327(coxS_cutS) TTX_0328(coxM_cutM)
 » show all
1  [PMID:10636886]
Gremer L, Kellner S, Dobbek H, Huber R, Meyer O
Binding of flavin adenine dinucleotide to molybdenum-containing carbon monoxide dehydrogenase from Oligotropha carboxidovorans. Structural and functional analysis of a carbon monoxide dehydrogenase species in which the native flavoprotein has been replaced by its recombinant counterpart produced in Escherichia coli.
J Biol Chem 275:1864-72 (2000)
2  [PMID:12475995]
Dobbek H, Gremer L, Kiefersauer R, Huber R, Meyer O
Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution.
Proc Natl Acad Sci U S A 99:15971-6 (2002)
3  [PMID:12515558]
Gnida M, Ferner R, Gremer L, Meyer O, Meyer-Klaucke W
A novel binuclear [CuSMo] cluster at the active site of carbon monoxide dehydrogenase: characterization by X-ray absorption spectroscopy.
Biochemistry 42:222-30 (2003)
4  [PMID:16091936]
Resch M, Dobbek H, Meyer O
Structural and functional reconstruction in situ of the [CuSMoO2] active site of  carbon monoxide dehydrogenase from the carbon monoxide oxidizing eubacterium Oligotropha carboxidovorans.
J Biol Inorg Chem 10:518-28 (2005)
5  [PMID:21275368]
Wilcoxen J, Zhang B, Hille R
Reaction of the molybdenum- and copper-containing carbon monoxide dehydrogenase from Oligotropha carboxydovorans with quinones.
Biochemistry 50:1910-6 (2011)
6  [PMID:25377894]
Pelzmann AM, Mickoleit F, Meyer O
Insights into the posttranslational assembly of the Mo-, S- and Cu-containing cluster in the active site of CO dehydrogenase of Oligotropha carboxidovorans.
J Biol Inorg Chem 19:1399-414 (2014)
7  [PMID:25156151]
Hille R, Dingwall S, Wilcoxen J
The aerobic CO dehydrogenase from Oligotropha carboxidovorans.
J Biol Inorg Chem 20:243-51 (2015)
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