KEGG   ENZYME: 1.21.3.1Help
Entry
EC 1.21.3.1                 Enzyme                                 

Name
isopenicillin-N synthase;
isopenicillin N synthetase
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With oxygen as acceptor
BRITE hierarchy
Sysname
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)
Reaction(IUBMB)
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O
Reaction(KEGG)
(other) R04872
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Substrate
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine;
O2 [CPD:C00007]
Product
isopenicillin N [CPD:C05557];
H2O [CPD:C00001]
Comment
Forms part of the penicillin biosynthesis pathway (for pathway, click here).
History
EC 1.21.3.1 created 2002
Pathway
ec00311  Penicillin and cephalosporin biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K04126  isopenicillin-N synthase
Genes
ANI: AN2622.2
AOR: AO090038000544
AFV: AFLA_070870
PCS: Pc21g21380(ips)
ABE: ARB_02225
TVE: TRV_00552
SCT: SCAT_5683(pcbC)
SCY: SCATT_56830
Taxonomy
Reference
1  [PMID:1588566]
  Authors
Huffman GW, Gesellchen PD, Turner JR, Rothenberger RB, Osborne HE, Miller FD, Chapman JL, Queener SW.
  Title
Substrate specificity of isopenicillin N synthase.
  Journal
J Med Chem 35:1897-914 (1992)
Reference
2  [PMID:7791906]
  Authors
Roach PL, Clifton IJ, Fulop V, Harlos K, Barton GJ, Hajdu J, Andersson I, Schofield CJ, Baldwin JE.
  Title
Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
  Journal
Nature 375:700-4 (1995)
DOI:10.1038/375700a0
  Sequence
[ani:AN2622.2]
Other DBs
ExplorEnz - The Enzyme Database: 1.21.3.1
IUBMB Enzyme Nomenclature: 1.21.3.1
ExPASy - ENZYME nomenclature database: 1.21.3.1
BRENDA, the Enzyme Database: 1.21.3.1
CAS: 78642-31-6
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