KEGG   ENZYME: 1.3.1.113
Entry
EC 1.3.1.113                Enzyme                                 
Name
(4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase;
bprA (gene name);
scbC (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
[(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl-phosphate:NADP+ oxidoreductase
Reaction(IUBMB)
a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP+ = a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + NADPH + H+ [RN:R11927]
Reaction(KEGG)
R11927
Substrate
[(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate [CPD:C21773];
NADP+ [CPD:C00006]
Product
(4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate [CPD:C21774];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacteria Streptomyces griseus and Streptomyces coelicolor, is involved in the biosynthesis of gamma-butyrolactone autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.
History
EC 1.3.1.113 created 2017
Orthology
K22462  (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase
Genes
SCOSCO6267(SCAH10.32)
SMASAVERM_3525
SGRSGR_6890
SGBWQO_00735
SHYSHJG_4002 SHJG_8652
SHOSHJGH_3767 SHJGH_8412
SSOII1A49_09945
SDVBN159_2281
SFISFUL_270
SLVSLIV_06810
SGUSGLAU_25505
SVTSVTN_03090
SCZABE83_34270
SRWTUE45_pSRc_0611(azoB)
SPAVSpa2297_32645
SCADDN051_10580
SLSSLINC_6538
SSIAA7J05_00555
SVUB1H20_00405
SLXSLAV_40305(azoB6)
SGZC0216_31800
SNKCP967_15140 CP967_31570
SFICEIZ62_19135
SPADDVK44_34910
SCAVCVT27_00250
SCINCP977_28625
SPACB1H29_00925 B1H29_36140
SCOECP976_35715
SSPBCP982_41460
SCALI6J39_00525
SXNIAG42_36220
SGJIAG43_33755
SDDD9753_04945
SACTDMT42_30655
KABB7C62_00285
 » show all
Reference
1  [PMID:17277085]
  Authors
Kato JY, Funa N, Watanabe H, Ohnishi Y, Horinouchi S
  Title
Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces.
  Journal
Proc Natl Acad Sci U S A 104:2378-83 (2007)
DOI:10.1073/pnas.0607472104
Reference
2  [PMID:29510026]
  Authors
Biarnes-Carrera M, Lee CK, Nihira T, Breitling R, Takano E
  Title
Orthogonal Regulatory Circuits for Escherichia coli Based on the gamma-Butyrolactone System of Streptomyces coelicolor.
  Journal
ACS Synth Biol 7:1043-1055 (2018)
DOI:10.1021/acssynbio.7b00425
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.113
IUBMB Enzyme Nomenclature: 1.3.1.113
ExPASy - ENZYME nomenclature database: 1.3.1.113
BRENDA, the Enzyme Database: 1.3.1.113
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