KEGG   ENZYME: 1.3.1.36
Entry
EC 1.3.1.36                 Enzyme                                 

Name
geissoschizine dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
geissoschizine:NADP+ 4,21-oxidoreductase
Reaction(IUBMB)
geissoschizine + NADP+ = 4,21-didehydrogeissoschizine + NADPH [RN:R03860]
Reaction(KEGG)
R03860
Substrate
geissoschizine [CPD:C02151];
NADP+ [CPD:C00006]
Product
4,21-didehydrogeissoschizine;
NADPH [CPD:C00005]
Comment
Involved in the interconversion of heteroyohimbine alkaloids in Catharanthus roseus.
History
EC 1.3.1.36 created 1986
Pathway
ec00901  Indole alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K23493  geissoschizine synthase
Reference
1
  Authors
Pfitzner, A. and Stockigt, J.
  Title
Partial-purification and characterization of geissoschizine dehydrogenase from suspension-cultures of Catharanthus roseus.
  Journal
Phytochemistry 21:1585-1588 (1982)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.36
IUBMB Enzyme Nomenclature: 1.3.1.36
ExPASy - ENZYME nomenclature database: 1.3.1.36
BRENDA, the Enzyme Database: 1.3.1.36
CAS: 84399-94-0
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