EC 126.96.36.199 Enzyme
enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific);
enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase;
NADPH 2-enoyl Co A reductase;
enoyl-[acyl-carrier-protein] reductase (NADPH2, A-specific);
acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (A-specific);
enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific);
acyl-[acyl-carrier protein]:NADP+ oxidoreductase (A-specific)
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
acyl-[acyl-carrier protein]:NADP+ oxidoreductase (Re-specific)
an acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+ [RN:
acyl-[acyl-carrier protein] [CPD:
trans-2,3-dehydroacyl-[acyl-carrier protein] [CPD:
This enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to an acyl-carrier protein. It is one of the activities of EC
, fatty-acid synthase system. The mammalian enzyme is Re-specific with respect to NADP+. cf. EC
, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC
, enoyl-[acyl-carrier-protein] reductase (NADPH).
EC 188.8.131.52 created 1986, modified 2013, modified 2018
Dugan RE, Slakey LL, Porter JW.
Stereospecificity of the transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate to the acyl chain in the dehydrogenase-catalyzed reactions of fatty acid synthesis.
J Biol Chem 245:6312-6 (1970)
Carlisle-Moore L, Gordon CR, Machutta CA, Miller WT, Tonge PJ
Substrate recognition by the human fatty-acid synthase.
J Biol Chem 280:42612-8 (2005)
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IUBMB Enzyme Nomenclature:
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