| Entry |
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| Name |
enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific);
acyl-ACP dehydrogenase;
enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase;
NADPH 2-enoyl Co A reductase;
enoyl-ACp reductase;
enoyl-[acyl-carrier-protein] reductase (NADPH2, A-specific);
acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (A-specific);
enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific);
acyl-[acyl-carrier protein]:NADP+ oxidoreductase (A-specific)
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
acyl-[acyl-carrier protein]:NADP+ oxidoreductase (Re-specific)
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| Reaction(IUBMB) |
an acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+ [RN: R01404]
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| Reaction(KEGG) |
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| Substrate |
acyl-[acyl-carrier protein] [CPD: C00173];
NADP+ [CPD: C00006]
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| Product |
trans-2,3-dehydroacyl-[acyl-carrier protein] [CPD: C00693];
NADPH [CPD: C00005];
H+ [CPD: C00080]
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| Comment |
This enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to an acyl-carrier protein. It is one of the activities of EC 2.3.1.85, fatty-acid synthase system. The mammalian enzyme is Re-specific with respect to NADP+. cf. EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.3.1.104, enoyl-[acyl-carrier-protein] reductase (NADPH).
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| History |
EC 1.3.1.39 created 1986, modified 2013, modified 2018
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| Reference |
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| Authors |
Dugan RE, Slakey LL, Porter JW. |
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| Title |
Stereospecificity of the transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate to the acyl chain in the dehydrogenase-catalyzed reactions of fatty acid synthesis. |
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| Journal |
J Biol Chem 245:6312-6 (1970) |
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| Reference |
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| Authors |
Carlisle-Moore L, Gordon CR, Machutta CA, Miller WT, Tonge PJ |
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| Title |
Substrate recognition by the human fatty-acid synthase. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.3.1.39 |
| ExPASy - ENZYME nomenclature database: | 1.3.1.39 |
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| LinkDB |
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