KEGG   ENZYME: 1.3.1.45
Entry
EC 1.3.1.45                 Enzyme                                 
Name
2'-hydroxyisoflavone reductase;
NADPH:2'-hydroxyisoflavone oxidoreductase;
isoflavone reductase;
2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
vestitone:NADP+ oxidoreductase
Reaction(IUBMB)
vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+ [RN:R06562]
Reaction(KEGG)
R06562;
(other) R06563 R07747 R07751
Substrate
vestitone [CPD:C00786];
NADP+ [CPD:C00006]
Product
2'-hydroxyformononetin [CPD:C02920];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
In the reverse reaction, a 2'-hydroxyisoflavone is reduced to an isoflavanone; 2'-hydroxypseudobaptigenin also acts. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.
History
EC 1.3.1.45 created 1990
Pathway
ec00943  Isoflavonoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K05281  2'-hydroxyisoflavone reductase
Genes
GMX100778149 100781316(IFR) 100781863 547659
GSJ114372907 114374345 114420398 114420408
PVUPHAVU_002G032900g PHAVU_002G033000g
VRA106776923 106777314 106778034 106778035
VAR108335124 108335125
VUN114168785 114172980 114173087
CCAJ109801392 109801470 109801488
APRC113868882 113869189
MTRMTR_5g020760 MTR_5g020800
CAM101508729(IFR)
LJALj2g3v1734650.1(Lj2g3v1734650.1) Lj2g3v1734650.2(Lj2g3v1734650.2)
ADU107487966
AIP107642895
AHF112749381 112800734
 » show all
Reference
1
  Authors
Tiemann, K., Hinderer, W. and Barz, W.
  Title
Isolation of NADPH:isoflavone oxidoreductase, a new enzyme of pterocarpan biosynthesis in cell suspensions of Cicer arietinum.
  Journal
FEBS Lett 213:324-328 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.45
IUBMB Enzyme Nomenclature: 1.3.1.45
ExPASy - ENZYME nomenclature database: 1.3.1.45
BRENDA, the Enzyme Database: 1.3.1.45
CAS: 128449-69-4
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