| Entry |
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| Name |
arogenate dehydrogenase (NADP+);
arogenic dehydrogenase (ambiguous);
pretyrosine dehydrogenase (ambiguous);
TyrAAT1;
TyrAAT2;
TyrAa
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
L-arogenate:NADP+ oxidoreductase (decarboxylating)
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| Reaction(IUBMB) |
L-arogenate + NADP+ = L-tyrosine + NADPH + CO2 [RN: R00733]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NADP+-dependent enzymes usually predominate in higher plants.The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 and the TyrAAT1 isoform of the plant Arabidopsis thaliana cannot use prephenate as a substrate, while the Arabidopsis isoform TyrAAT2 can use it very poorly [2,3].
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| History |
EC 1.3.1.78 created 2005
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| Pathway |
| ec00400 | Phenylalanine, tyrosine and tryptophan biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K15226 | arogenate dehydrogenase (NADP+) |
| K15227 | arogenate dehydrogenase (NADP+), plant |
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| Genes |
» show all
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| Reference |
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| Authors |
Gaines CG, Byng GS, Whitaker RJ, Jensen RA |
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| Title |
L-tyrosine regulation and biosynthesis via arogenate dehydrogenase in suspension-cultured cells of Nicotiana silvestris Speg. et Comes. |
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| Journal |
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| Reference |
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| Authors |
Rippert P, Matringe M |
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| Title |
Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Bonner CA, Jensen RA, Gander JE, Keyhani NO. |
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| Title |
A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.3.1.78 |
| ExPASy - ENZYME nomenclature database: | 1.3.1.78 |
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| LinkDB |
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