Entry |
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Name |
arogenate dehydrogenase (NADP+);
arogenic dehydrogenase (ambiguous);
pretyrosine dehydrogenase (ambiguous);
TyrAAT1;
TyrAAT2;
TyrAa
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Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
L-arogenate:NADP+ oxidoreductase (decarboxylating)
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Reaction(IUBMB) |
L-arogenate + NADP+ = L-tyrosine + NADPH + CO2 [RN: R00733]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NADP+-dependent enzymes usually predominate in higher plants.The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 and the TyrAAT1 isoform of the plant Arabidopsis thaliana cannot use prephenate as a substrate, while the Arabidopsis isoform TyrAAT2 can use it very poorly [2,3].
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History |
EC 1.3.1.78 created 2005
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Pathway |
ec00400 | Phenylalanine, tyrosine and tryptophan biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K15226 | arogenate dehydrogenase (NADP+) |
K15227 | arogenate dehydrogenase (NADP+), plant |
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Genes |
» show all
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Reference |
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Authors |
Gaines CG, Byng GS, Whitaker RJ, Jensen RA |
Title |
L-tyrosine regulation and biosynthesis via arogenate dehydrogenase in suspension-cultured cells of Nicotiana silvestris Speg. et Comes. |
Journal |
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Reference |
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Authors |
Rippert P, Matringe M |
Title |
Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana. |
Journal |
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Sequence |
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Reference |
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Authors |
Bonner CA, Jensen RA, Gander JE, Keyhani NO |
Title |
A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.3.1.78 |
ExPASy - ENZYME nomenclature database: | 1.3.1.78 |
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LinkDB |
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