| Entry |
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| Name |
arogenate dehydrogenase [NAD(P)+];
arogenic dehydrogenase (ambiguous);
cyclohexadienyl dehydrogenase;
pretyrosine dehydrogenase (ambiguous)
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
L-arogenate:NAD(P)+ oxidoreductase (decarboxylating)
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| Reaction(IUBMB) |
L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2 [RN: R00732 R00733]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). Enzymes that can utilize both cofactors have been reported from some Proteobacteria, including Burkholderia caryophylli, Burkholderia cepacia, Pseudomonas marginata and Delftia acidovorans.
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| History |
EC 1.3.1.79 created 2005
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| Pathway |
| ec00400 | Phenylalanine, tyrosine and tryptophan biosynthesis |
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| Reference |
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| Authors |
Byng GS, Whitaker RJ, Gherna RL, Jensen RA |
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| Title |
Variable enzymological patterning in tyrosine biosynthesis as a means of determining natural relatedness among the Pseudomonadaceae. |
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| Journal |
J Bacteriol 144:247-57 (1980) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.3.1.79 |
| ExPASy - ENZYME nomenclature database: | 1.3.1.79 |
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| LinkDB |
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