| Entry |
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| Name |
acyl-CoA dehydrogenase (NADP+);
2-enoyl-CoA reductase;
dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate);
enoyl coenzyme A reductase;
crotonyl coenzyme A reductase;
crotonyl-CoA reductase;
acyl-CoA dehydrogenase (NADP+)
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
acyl-CoA:NADP+ 2-oxidoreductase
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| Reaction(IUBMB) |
acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+ [RN: R00385]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The liver enzyme acts on enoyl-CoA derivatives of carbon chain length 4 to 16, with optimum activity on 2-hexenoyl-CoA. In Escherichia coli, cis-specific and trans-specific enzymes exist [EC 1.3.1.37 cis-2-enoyl-CoA reductase (NADPH) and EC 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)].
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| History |
EC 1.3.1.8 created 1972, modified 1986
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| Pathway |
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| Reference |
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| Authors |
Dommes V, Luster W, Cvetanovic M, Kunau WH. |
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| Title |
Purification by affinity chromatography of 2,4-dienoyl-CoA reductases from bovine liver and Escherichia coli. |
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| Journal |
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| Reference |
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| Authors |
Seubert W, Lamberts I, Kramer R, Ohly B |
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| Title |
On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.3.1.8 |
| ExPASy - ENZYME nomenclature database: | 1.3.1.8 |
| BRENDA, the Enzyme Database: | 1.3.1.8 |
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| LinkDB |
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