Entry |
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Name |
acyl-CoA dehydrogenase (NADP+);
2-enoyl-CoA reductase;
dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate);
enoyl coenzyme A reductase;
crotonyl coenzyme A reductase;
crotonyl-CoA reductase;
acyl-CoA dehydrogenase (NADP+)
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Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
acyl-CoA:NADP+ 2-oxidoreductase
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Reaction(IUBMB) |
acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+ [RN: R00385]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The liver enzyme acts on enoyl-CoA derivatives of carbon chain length 4 to 16, with optimum activity on 2-hexenoyl-CoA. In Escherichia coli, cis-specific and trans-specific enzymes exist [EC 1.3.1.37 cis-2-enoyl-CoA reductase (NADPH) and EC 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)].
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History |
EC 1.3.1.8 created 1972, modified 1986
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Pathway |
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Reference |
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Authors |
Dommes V, Luster W, Cvetanovic M, Kunau WH. |
Title |
Purification by affinity chromatography of 2,4-dienoyl-CoA reductases from bovine liver and Escherichia coli. |
Journal |
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Reference |
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Authors |
Seubert W, Lamberts I, Kramer R, Ohly B |
Title |
On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.3.1.8 |
ExPASy - ENZYME nomenclature database: | 1.3.1.8 |
BRENDA, the Enzyme Database: | 1.3.1.8 |
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LinkDB |
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