KEGG ENZYME: 1.3.1.83

ENZYME: 1.3.1.83

Entry

EC 1.3.1.83                 Enzyme

Name

geranylgeranyl diphosphate reductase;
geranylgeranyl reductase;
CHL P

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

geranylgeranyl-diphosphate:NADP+ oxidoreductase

Reaction(IUBMB)

phytyl diphosphate + 3 NADP+ = geranylgeranyl diphosphate + 3 NADPH + 3 H+ [RN:R02063]

Reaction(KEGG)

R02063

Substrate

phytyl diphosphate [CPD:C05427];
NADP+ [CPD:C00006]

Product

geranylgeranyl diphosphate [CPD:C00353];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

This enzyme also acts on geranylgeranyl-chlorophyll a. The reaction occurs in three steps. Which order the three double bonds are reduced is not known.

History

EC 1.3.1.83 created 2009

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K10960

geranylgeranyl diphosphate/geranylgeranyl-bacteriochlorophyllide a reductase

Genes

ATH:

AT1G74470

ALY:

9325042

CRB:

17894023

CSAT:

104702172 104713087 104751317

EUS:	EUTSA_v10018504mg

BRP:	103831923 103852907

BNA:	106354395 106381375 106405742 106430268

BOE:	106300254 106327384

RSZ:	108816096 108818449

THJ:

104813881

CPAP:

110806885 110823599

CIT:	102606922 102628832

CIC:	CICLE_v10015206mg CICLE_v10020061mg

PVY:	116122320 116134344

MINC:

123204610 123212206

TCC:	18590126 18604703

GRA:	105788420 105799295

GHI:	107890070 107891506 107897682 107949818

GAB:	108457350 108483290

HSYR:

120142800 120158728 120168859

DZI:	111286751 111290004 111317484

EGR:	104419806 104433929

GMX:	100779933 100787525 100814603

GSJ:	114392628 114400616 114411854

PVU:	PHAVU_003G189600g PHAVU_008G208000g

VRA:	106764806 106768993

VAR:	108323777 108338269

VUN:	114178019 114195668

VUM:

124826967

CCAJ:

109808310 109808821

APRC:

113846755 113847511

MTR:	11429848 120580108

TPRA:

123884252 123921785

CAM:	101494746 101504312

PSAT:

127073792 127117929

VVO:	131615961 131635191

LJA:	Lj2g3v2971720.1(Lj2g3v2971720.1)

ADU:	107468034 107492652 107496713

AIP:	107608565 107633107

AHF:	112702176 112710187 112722504 112762670

LANG:

109344115 109353463 109360295 109362259

PCIN:

129318012 129320891

QSA:	O6P43_001962 O6P43_013942 O6P43_020843 O6P43_022855

FVE:	101303515 101305804

RCN:	112179713 112181866

PPER:

18772334 18776056

PMUM:

103338504

PAVI:

110762352 110766036

PDUL:

117627412 117631371

MDM:	103424544 103437824 103441948

MSYL:

126591304 126598918 126625843

PXB:

103931434

ZJU:	107410339 107419241

MNT:	21399031 21405360

CSAV:

115709045 115718586

CSV:	101221755 105435233

CMO:	103491620 103493994(GGPR)

BHJ:	120071403 120088075

CMAX:

111471190 111483717 111484810

CMOS:

111429842 111440944 111448779

CPEP:

111777177 111779576 111793372 111793523

RCU:	8263422 8268692

JCU:	105629331 105640543

HBR:	110650769 110655700 110655724

MESC:

110599909

POP:	18098056 7460095 7484745

PEU:	105112328 105112893

PALZ:

118029001 118032400 118038976

JRE:	108995457 109018163

CILL:

122281679 122281811

CAVE:

132164172 132176034

QSU:

111998707

QLO:	115963881 115986518

TWL:	119990626 120009962

VVI:	100243277 100253115

VRI:	117904575 117915532

SLY:	101262299 101266160

SPEN:

107012756 107014180

SOT:	102598599 102599900

SSTN:

125853391 125857621

SDUL:

129884876 129896300

CANN:

107854916 107862250

LBB:	132632936 132644837

NTA:	107769989 107783257(chlP) 107803012 107830453(GGR)

NSY:	104227957 104228313

NTO:	104107635 104116841

NAU:	109223807 109226123

INI:	109148056 109193543

ITR:	116010427 116029088

SIND:

105157101 105170139

OEU:	111388353 111394843 111394844

EGT:	105957028 105959765

SSPL:

121755671 121758317 121761887 121765547

SMIL:

131020407 131022361

SHIS:

125208823 125222222

APAN:

127241071 127246011

HAN:	110873825 110879946 110930151 110941795

ECAD:

122589605 122609866

LSV:	111877732 111877733 111877734 111877756 111895388 111909735

CCAV:

112510132 112510388 112514549

DCR:	108195887 108220046

CSIN:

114315105

RVL:	131309926 131309927 131313121

AEW:	130754337 130761079 130761128

BVG:	104894042 104899916

SOE:	110798610 110799455

CQI:	110683513 110688219 110700603 110726445

ATRI:

130799128 130814219

MOF:	131146344 131148010

NNU:

104602940

MING:

122076893

TSS:

122654450

PSOM:

113280589 113303555 113317764 113333991

OSA:	4326207 4330711

DOSA:

Os01t0265000-00(Os01g0265000) Os02t0744900-01(Os02g0744900)

OBR:	102704037 121055138

OGL:	127763342 127773849

BDI:	100821798 100836154

ATS:	109757451 109766926

TDC:	119267922 119275794 119317865 119325740

TAES:

123061037 123069628 123078110 123128382 123138239 780623

TUA:

125514635

LPER:

127306108 127342370

LRD:	124659248 124659493 124693120 124693176

SBI:	8075711 8085832

ZMA:	100283007 103649981

SITA:

101769245 101784760

SVS:	117837921 117857077

PVIR:

120641609 120657231 120672971 120706447

PHAI:

112892306 112902015

PDA:	103716420 103718980

EGU:	105032269 105058545

MUS:	103989643 103996389

ZOF:	121981453 122025374 122038090 122056583

DCT:	110107118 110107874

PEQ:

110032603

AOF:

109834138

MSIN:

131226795 131242072

NCOL:

116252913 116253458

ATR:

110007115

SMO:	SELMODRAFT_150713 SELMODRAFT_271030

PPP:	112275265 112295439 112296001

CRE:	CHLRE_01g050950v5

VCN:	VOLCADRAFT_77841

MNG:	MNEG_11486

CSL:	COCSUDRAFT_31829

CVR:	CHLNCDRAFT_29491

APRO:

F751_0551

OLU:	OSTLU_119498(ggh)

OTA:	OT_ostta02g02510

BPG:	Bathy14g02760

MIS:	MICPUN_91628

MPP:	MICPUCDRAFT_49640(JGI:MicpuC2_49640)

CME:	CYME_CMJ154C

GSL:	Gasu_07190

CCP:	CHC_T00009478001

SMIN:

v1.2.003912.t1(symbB.v1.2.003912.t1) v1.2.012563.t1(symbB.v1.2.012563.t1) v1.2.013265.t1(symbB.v1.2.013265.t1) v1.2.013265.t2(symbB.v1.2.013265.t2) v1.2.021307.t1(symbB.v1.2.021307.t1) v1.2.025959.t1(symbB.v1.2.025959.t1)

PTI:	PHATRDRAFT_50650

FCY:	FRACYDRAFT_267781(GGR)

TPS:	THAPSDRAFT_10234

AAF:	AURANDRAFT_31415

EHX:	EMIHUDRAFT_432259

GTT:	GUITHDRAFT_91519

PAQM:

E0F26_06715

ALV:	Alvin_2646

ATEP:

Atep_05700(bchP)

TVI:	Thivi_2414

TMB:	Thimo_0922

MPUR:

MARPU_13980

TSY:	THSYN_31555

TTP:	E6P07_13125

THIP:

N838_12615

CJAP:

GWK36_13340

THIM:

KFB96_13295

TBOG:

LT988_09015

TLR:	Thiosp_04088(bchP)

TFRI:

Thiofri_01159(bchP)

TWG:	Thiowin_00724(bchP)

HHA:

Hhal_1602

HHK:	HH1059_06380(bchP)

HHC:	M911_08255

EBS:	ECTOBSL9_2972

PDQ:	CL55_00013270

PANI:

DCO16_03310

PCOS:

C2747_06795

PWU:	A8O14_08475

RAC:	RA876_06160

LIM:	L103DPR2_01008(kmo)

LIH:	L63ED372_00664

HYR:	BSY239_1278

HCZ:	G9Q37_21655

MPT:

Mpe_A2779

METP:

C1M51_03440

RGE:	RGE_33390(bchP)

RBN:	RBXJA2T_09597

RDP:	RD2015_1020

ROI:	N4261_01125

ATER:

MW290_02645

METR:

BSY238_2473

BEB:	AEM42_07610

RPOD:

E0E05_11930

AGC:	BSY240_3640

RROS:

D4A92_02775

ABAW:

D5400_05075

PDES:

FE840_002465

BRA:	BRADO1632(bchP)

BBT:	BBta_6424(bchP)

BRS:	S23_19290(bchP)

AOL:

S58_59050

BRO:	BRAD285_5768(bchP)

BRQ:	CIT40_23885

BGZ:	XH91_02710

BBET:

F8237_24730

BROS:

QUH67_09890

RPA:	TX73_007880

RPB:

RPB_3990

RPC:

RPC_1304

RPD:

RPD_3745

RPE:

RPE_1338

RPT:

Rpal_1721

RPX:	Rpdx1_3987

BOS:	BSY19_4030

MEA:	Mex_1p5279(bchP)

MDI:	METDI5879(bchP)

MEX:

Mext_4822

MCH:

Mchl_5289

MPO:

Mpop_5367

MZA:	B2G69_06095

MRD:	Mrad2831_1854

MET:

M446_3712

MOR:	MOC_2259(bchP)

META:

Y590_24640

MAQU:

Maq22A_c01650(fixC)

MPHY:

MCBMB27_01476

MEE:	DA075_04020

METD:

C0214_26380

METX:

A3862_21655

METS:

DK389_01100

METI:

DK427_18055

MMES:

MMSR116_22220

MTEA:

DK419_04980

MIND:

mvi_09110(bchP)

MOG:	MMB17_13825

MTAD:

M6G65_04510

MSL:

Msil_2063

BBAR:

RHAL1_00139(bchP)

RVA:

Rvan_1004

RLAC:

QMO75_03335

BVR:

BVIR_564

BLAG:

BLTE_02000(bchP)

MROS:

EHO51_17145

CMET:

K6K41_01510

AUZ:	Sa4125_27490

AUB:	LXB15_06250

JIE:	OH818_05165

BSB:	Bresu_3058

BRL:	BZG35_15510

BREA:

HZ989_04545

RUT:	FIU92_10010

JAN:	Jann_0167(bchP)

RDE:	RD1_0146(bchP)

RLI:	RLO149_p940650(bchP)

RPON:

G3256_18955

DSH:	Dshi_3528(bchP)

RED:	roselon_01089

SUAM:

BOO69_19355

SUAL:

KDD17_18420

TOM:	BWR18_20045

RMM:	ROSMUCSMR3_00875

ROK:	RAK1035_3745

RID:	RIdsm_01785

ROM:	EI983_05580

ROH:	FIU89_14070

THAA:

CFI11_23675

ROT:	FIV09_18125

RMH:	LVO79_15100

MALU:

KU6B_16760

PLCG:

RVY76_14000

MARU:

FIU81_13800

RMAI:

MACH21_32910(bchP)

RSP:	RSP_0277(bchP)

RSH:	Rsph17029_1920

RSQ:	Rsph17025_1018

RSK:	RSKD131_1603

CAZT:

LV780_04440

RCP:	RCAP_rcc00673(bchP)

RBL:	B6K69_03440

PTP:	RCA23_c29730(bchP)

RSU:

NHU_00205

RHM:	B5V46_02425

RHC:

RGUI_1992

LVS:	LOKVESSMR4R_03330

RBG:	BG454_02965

GEH:	HYN69_05455

TAW:	EI545_18875

POZ:	I0K15_16865

NSM:	JO391_16395

PBAE:

P8S53_17155

FAQ:	G5B39_09965

RBX:	I3V23_09445

HBC:	AEM38_14345

NOT:	C7W88_00530

NGF:	FRF71_09195

NOG:	GKE62_08485

SPHI:

TS85_23035

SSAN:

NX02_18305

SCHY:

GVO57_11495

SAER:

NEF64_07815

SGLC:

M1K48_13670

SQO:	NMP03_02265

SRAD:

LLW23_12285

CIJ:	WG74_05085

BLAS:

BSY18_2715

BFW:	B5J99_04525

PALG:

HFP57_06900

PARJ:

J4G78_07490

SAND:

H3309_05840

POQ:	KZX46_18575

PMEA:

KTC28_16885

ALH:	G6N82_11480

ARUE:

QQX03_04260

ELQ:	Ga0102493_111829

ERK:	CD351_13920

ERF:	FIU90_13875

PNS:	A9D12_01330

PORL:

BG023_112679

PHZ:	CHX26_14545

POT:	E2E27_07290

AMV:	ACMV_18910(bchP)

RFL:	Rmf_21930(bchP)

SRF:	LHU95_14010

RAP:	RHOA_2392(bchP)

NCB:	C0V82_18025

SKT:	IGS68_17205

SMUC:

JL100_008830

SROE:

JL101_015385

RRU:

Rru_A0629

RRF:

F11_03225

RCE:	RC1_2080(bchP)

RPM:	RSPPHO_00051(bchP)

ELIO:

KO353_02765

THAR:

T8K17_11905

SULR:

B649_08370

ANT:	Arnit_0931

SUN:

SUN_1446

NAM:

NAMH_1575

NAP:	C3L23_08185

CMED:

FE773_02195

CPAF:

C6V80_00880

SYN:

sll1091

SYZ:	MYO_117820

SYY:	SYNGTS_1764(chlP)

SYT:	SYNGTI_1764(chlP)

SYS:	SYNPCCN_1763(chlP)

SYQ:	SYNPCCP_1763(chlP)

SYJ:	D082_12250(chlP)

SYO:	C7I86_09185(chlP)

SYC:	syc1129_d(chlP)

SYU:	M744_01055

SYF:	Synpcc7942_0385

SYD:	Syncc9605_1240

SYE:	Syncc9902_1239

SYG:	sync_1282(chlP)

SYR:	SynRCC307_1267(chlP)

SYX:	SynWH7803_1317(chlP)

CYA:	CYA_0072(chlP)

CYB:	CYB_1761(chlP)

SYNE:

Syn6312_1774

SYNP:

Syn7502_00552

SYNK:

KR100_09500

SYNR:

KR49_02790

SYND:

KR52_10480

SYH:	Syncc8109_1450(chlP)

SYNW:

SynWH8103_01240(chlP)

SYNC:

CB0101_03220(chlP)

SYNY:

BM449_10985

DSL:	Dacsa_0177

SYW:	SYNW1097(chlP)

CGC:	Cyagr_0506

CYI:	CBM981_0621(chlP)

PMA:	Pro_0832(chlP)

PMM:	PMM0760(chlP)

PMT:

PMT_0577

PMN:	PMN2A_0164

PMI:	PMT9312_0768

PMB:	A9601_08221(chlP)

PMC:	P9515_08231(chlP)

PMF:	P9303_16731(chlP)

PMG:	P9301_08201(chlP)

PMH:	P9215_08541(chlP)

PMJ:	P9211_10031(chlP)

PME:	NATL1_07961(chlP)

PRC:

EW14_0849

PRM:

EW15_0845

WNA:	KA717_28720(chlP)

CMP:	Cha6605_5468

CYN:	Cyan7425_1664

CEP:	Cri9333_1154

TVN:	NIES2134_123820(chlP)

SLW:	BRW62_10580

AMR:	AM1_2046(chlP)

TEL:	tll0150(chlP)

THN:	NK55_09970(chlP)

THEC:

FFX45_11910(chlP)

TSZ:	OOK60_18035(chlP)

LEN:	LEP3755_60180

LET:	O77CONTIG1_04651

LBO:	LBWT_24580

KOV:	K9N68_30930(chlP)

LSC:	KIK02_02930(chlP)

LSK:	J5X98_01545(chlP)

HHG:	XM38_015980(chlP_2)

PSEU:

Pse7367_0953

PSER:

ABRG53_0355(chlP)

PGX:	OA858_16810(chlP)

THEU:

HPC62_18410(chlP)

TOG:	HNI00_14050(chlP)

TSIN:

OXH18_08110(chlP)

GLP:	Glo7428_1539

CHON:

NIES4102_17970(chlP)

GDU:	P0S91_17690(chlP)

GEN:	GM3709_1900

GEE:	GM3708_1376

CAN:	Cyan10605_1785

CSN:	Cyast_1975

CYL:	AA637_11455(chlP)

SYP:	SYNPCC7002_A2476(chlP)

SYV:	AWQ23_12350

SYL:	AWQ21_12135

LEP:	Lepto7376_1028

SYNN:

NIES970_05430(chlP)

MAR:	MAE_50020(chlP)

MPK:

VL20_2943

MIQ:	B5D77_11380

MVZ:	myaer102_23260(chlP)

HAO:	PCC7418_3094

ENN:	FRE64_09415(chlP)

CYU:	UCYN_09570

CYT:	cce_3146(chlP)

CWA:	CwatDRAFT_1268

CYP:	PCC8801_0178

CYH:	Cyan8802_0173

CYC:	PCC7424_4276

CYJ:	Cyan7822_2454

TER:

Tery_1823

ARP:	NIES39_E00570(chlP)

PAGH:

NIES204_40830(chlP)

PPSU:

NO713_00939(chlP)

PRUN:

PCC7821_04834(chlP)

OXY:	HCG48_23715(chlP)

MVAG:

D0A34_25150(chlP)

LFS:	HFV01_21020(chlP)

OAC:	Oscil6304_0501

ONI:	Osc7112_5726

MPRO:

BJP34_22960

PHOR:

JWS08_16450(chlP)

PYH:	NEA10_16600(chlP)

MIC:	Mic7113_4883

GEI:	GEI7407_0045

GVI:	glr4377(chlP)

GLJ:	GKIL_3454(chlP)

GML:	ISF26_05925(chlP)

ANA:	alr0128(chlP)

NPU:	Npun_F3720

NOS:	Nos7107_1348

NOP:	Nos7524_5371

NON:	NOS3756_20520

NFL:	COO91_03837

NOE:	CLI64_23700(chlP)

NSH:

GXM_02661

NED:	HUN01_21950(chlP)

NPZ:	ACX27_16515

AVA:

Ava_1497

NAZ:

Aazo_4038

ANB:	ANA_C12069(chlP)

ACY:	Anacy_4688

AWA:	AA650_02215

ANN:	EH233_05305(chlP)

CSG:	Cylst_2521

RSIN:

B6N60_01483

HBQ:	QI031_26515(chlP)

CALO:

Cal7507_0409

CALT:

Cal6303_4336

CALH:

IJ00_23305

CALN:

NIES2098_01640

CALS:

NIES3974_17590

RIV:	Riv7116_2307

FIS:	FIS3754_07060

NSPH:

BDGGKGIB_01472(kmo_1)

DOU:	BMF77_03658(kmo)

DFS:	HGD76_23605(chlP)

DHT:	NG743_16125(chlP)

CCUR:

IAR63_08040(chlP)

CRK:	L3I90_00445(chlP)

AFLO:

HEQ12_15450(chlP)

STOQ:

K2F26_14950(chlP)

AEE:	IM676_10450(chlP)

RCS:	NIES932_03680

TOQ:	HCG51_14735(chlP)

ALAX:

NIES50_23260

NCN:	BZZ01_13220

CTHE:

Chro_3960

PLP:	Ple7327_3206

SCS:	Sta7437_1400

STAN:

STA3757_13410(chlP)

GLT:	GlitD10_2510(bchP)

GCY:	LQF76_09125(chlP)

RRS:	RoseRS_3265

RCA:

Rcas_3751

CAU:

Caur_2087

CHL:	Chy400_2250

CAG:

Cagg_2633

VAB:	WPS_12930 WPS_26110

CTM:	Cabther_A0150

CVL:	J8C06_00995

CHLO:

J8C02_00760

GPH:	GEMMAAP_06365

GGR:	HKW67_08925

CTE:	CT2256(bchP)

CPC:

Cpar_0021

CLZ:	BIU88_11310

CCH:

Cag_0035

CPH:	Cpha266_0044

CPB:	Cphamn1_0023

CLI:

Clim_0022

PVI:

Cvib_0020

PLT:

Plut_0016

PPH:

Ppha_0029

PAA:

Paes_0023

PROC:

Ptc2401_00022(cbrA)

PRS:	B9H02_00110

PROS:

CHL67_00125

PROW:

OO006_00120

PROI:

OO005_00115

CTS:

Ctha_1271

TYE:	THEYE_A1608

DTP:	JZK55_04270

» show all

Reference

1 [PMID:16662918]

Authors

Soll J, Schultz G, Rudiger W, Benz J

Title

Hydrogenation of Geranylgeraniol : Two Pathways Exist in Spinach Chloroplasts.

Journal

Plant Physiol 71:849-854 (1983)
DOI:10.1104/pp.71.4.849

Reference

2 [PMID:10398704]

Authors

Tanaka R, Oster U, Kruse E, Rudiger W, Grimm B

Title

Reduced activity of geranylgeranyl reductase leads to loss of chlorophyll and tocopherol and to partially geranylgeranylated chlorophyll in transgenic tobacco plants expressing antisense RNA for geranylgeranyl reductase

Journal

Plant Physiol 120:695-704 (1999)
DOI:10.1104/pp.120.3.695

Sequence

[ag:CAA07683]

Reference

3 [PMID:9492312]

Authors

Keller Y, Bouvier F, d'Harlingue A, Camara B

Title

Metabolic compartmentation of plastid prenyllipid biosynthesis--evidence for the involvement of a multifunctional geranylgeranyl reductase.

Journal

Eur J Biochem 251:413-7 (1998)
DOI:10.1046/j.1432-1327.1998.2510413.x