KEGG   ENZYME: 1.3.1.86
Entry
EC 1.3.1.86                 Enzyme                                 
Name
crotonyl-CoA reductase;
butyryl-CoA dehydrogenase;
butyryl dehydrogenase;
unsaturated acyl-CoA reductase;
ethylene reductase;
enoyl-coenzyme A reductase;
unsaturated acyl coenzyme A reductase;
butyryl coenzyme A dehydrogenase;
short-chain acyl CoA dehydrogenase;
short-chain acyl-coenzyme A dehydrogenase;
3-hydroxyacyl CoA reductase;
butanoyl-CoA:(acceptor) 2,3-oxidoreductase;
CCR
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
butanoyl-CoA:NADP+ 2,3-oxidoreductase
Reaction(IUBMB)
butanoyl-CoA + NADP+ = (E)-but-2-enoyl-CoA + NADPH + H+ [RN:R09738]
Reaction(KEGG)
R09738
Substrate
butanoyl-CoA [CPD:C00136];
NADP+ [CPD:C00006]
Product
(E)-but-2-enoyl-CoA [CPD:C00877];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the reaction in the reverse direction. This enzyme from Streptomyces collinus is specific for (E)-but-2-enoyl-CoA, and is proposed to provide butanoyl-CoA as a starter unit for straight-chain fatty acid biosynthesis.
History
EC 1.3.1.86 created 2011
Pathway
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K17829  crotonyl-CoA reductase
Genes
ANTArnit_2215
DDSDdes_1332
DEFCNY67_08750(ccrA)
DOAAXF15_01755
RSUNHU_00907(ttmP)
NNONONO_c15260
NTPCRH09_08285(ccrA)
NAHF5544_31360(ccrA)
RFAA3L23_04984(ccrA2)
TPRTpau_3474
SCOSCO6473(SC9C7.09c)
SALBXNR_0456
SMASAVERM_1911(ccrA2) SAVERM_2890(ccrA1)
SGRSGR_1170
SGBWQO_29560
SCBSCAB_17621 SCAB_79701
SSXSACTE_5660
SVLStrvi_2501 Strvi_3810
SHYSHJG_7434
SHOSHJGH_7194
SRCM271_06415 M271_13255 M271_39450
SMALSMALA_1349 SMALA_1368 SMALA_6101 SMALA_7129
SSOII1A49_10240(ccrA) I1A49_10355(ccrA) I1A49_34355(ccrA) I1A49_39425(ccrA)
SCTSCAT_0122 SCAT_3263(ccr) SCAT_4859(ccr) SCAT_5748(ccrA)
SCYSCATT_01300 SCATT_32610 SCATT_48530 SCATT_57510
SFASfla_0905
SBHSBI_01394 SBI_02836
SVESVEN_6307
SDVBN159_0687 BN159_1952
SALSSLNWT_0464 SLNWT_7289
STRPF750_5949
SFISFUL_6327
SCIB446_01590(kirN) B446_29770 B446_33700(kirN)
SALUDC74_1416 DC74_6487
SALLSAZ_07600 SAZ_33460
SLVSLIV_06060(ccrA2)
SGUSGLAU_27255(ccrA2)
SVTSVTN_30770
STREGZL_00064 GZL_02323 GZL_09198 GZL_09349
SCWTU94_22520 TU94_27475
SLDT261_1717
SLCSL103_24360
SXISXIM_01950
STRMM444_04520 M444_27580
STRCAA958_28645 AA958_29285
SAMBSAM23877_5633(srm4) SAM23877_6067(ccr)
SPRISPRI_1330
SCZABE83_04720 ABE83_07185
SCXAS200_10820
SRWTUE45_01107(ccr_1) TUE45_07075(ccr_2)
STRFASR50_29040
SLEsle_13020(sle_13020)
SRNA4G23_04917(ccr)
SPAVSpa2297_26930 Spa2297_32695
STRTA8713_26360
SCLFBB341_03675
SGSAVL59_13890
STSIA4E84_33270
SKYD0C37_03820(ccrA)
SALWCP975_29945(ccrA)
SGMGCM10017557_10790(qor) GCM10017557_14280
SCADDN051_09610(ccrA)
SLSSLINC_6419 SLINC_6872 SLINC_8376
SNRSNOUR_10725(ccrA2) SNOUR_41350(ccr)
SPLULK06_027860
STRDNI25_06035
SNWBBN63_00225 BBN63_05335
SAUOBV401_10555 BV401_10670 BV401_34300 BV401_39275
SSIAA7J05_00360 A7J05_06520 A7J05_36375
SVUB1H20_30390
SPUNBFF78_09060 BFF78_11115
SGVB1H19_32470
SLAUSLA_6261 SLA_7255
SALFSMD44_00393(ccrA) SMD44_07018(ccrA)
SALJSMD11_0917(ccrA) SMD11_1338(ccrA)
SLXSLAV_08020(ccrA1)
SFKKY5_6787c KY5_7834
SNZDC008_28375(ccrA)
SGEDWG14_00538(ccr_1) DWG14_00548(ccr_2) DWG14_01738(ccrA2)
SRJSRO_1425
SLKSLUN_32575(ccrA)
SDXC4B68_06490(ccrA)
SGDELQ87_06715(ccrA)
SQZFQU76_28255(ccrA) FQU76_32240(ccrA)
SCYAEJ357_38675(ccrA)
SASTCD934_04580(ccrA)
SNQCP978_27100(ccrA)
STIRDDW44_26350(ccrA)
SKACP970_06740(ccrA)
SGZC0216_10225(ccrA) C0216_31390(ccrA)
SVNCP980_06480(ccrA)
SNKCP967_03935(ccrA)
SHAWCEB94_34120(ccrA) CEB94_37125(ccrA)
SRKFGW37_26435(ccrA)
SFICEIZ62_05455(ccrA)
SGALCP966_29715(ccrA)
SSPODDQ41_27620(ccrA)
SVRCP971_08930(ccrA)
SPADDVK44_29750(ccrA)
SFYGFH48_09625(ccrA)
SAQUEJC51_37845(ccrA)
SGFHEP81_01391(ccrA_1)
SCAVCVT27_29040(ccrA)
SSEOD0Z67_24055(ccrA)
SBYH7H31_05440(ccrA)
SRIMCP984_01705(ccrA) CP984_07145(ccrA)
SSUBCP968_06975(ccrA)
SPHVF9278_34525(ccrA) F9278_39485(ccrA)
SCINCP977_28235(ccrA)
SFUGCNQ36_27180(ccrA)
SPACB1H29_06755 B1H29_11735
STSUB7R87_01675 B7R87_28645
SCHACP983_08255(ccrA)
SGXH4W23_31955(ccrA)
SCOECP976_35275(ccrA)
SBATG4Z16_04710(ccrA)
SSPBCP982_33020(ccrA)
SNFJYK04_06750(ccrA2_1)
SPLACP981_31660(ccrA)
SBROGQF42_34505(ccrA)
STUIGCM10017668_58330
SATAC5746_34340(ccrA)
SCHFIPT68_30325(ccrA)
SHUNDWB77_01615(ccrA2)
SCYGS1361_04920(ccrA2) S1361_32255(ccr2)
SFEUIM697_30275(ccrA)
SLIAHA039_05415(ccrA) HA039_05625(ccrA)
SDWK7C20_30100(ccrA)
SVDCP969_31025(ccrA)
SCALI6J39_30195(ccrA)
SAUHSU9_028725(ccrA) SU9_031630(ccrA)
SFBCP974_26300(ccrA)
SMOBJ7W19_26405(ccrA)
SPRACP972_29695(ccrA)
SPEUCGZ69_30580(ccrA)
SROIIAG44_00130(ccrA) IAG44_07405(ccrA)
SXNIAG42_06400(ccrA)
SGJIAG43_27270(ccrA)
SHKJ2N69_31310(ccrA)
SANUK7396_06910(ccrA)
STRYEQG64_00020(ccrA) EQG64_30325(ccrA)
SDDD9753_06035(ccrA)
SACTDMT42_31230(ccrA)
KSKKSE_56510(ccr1) KSE_65530(ccr3) KSE_70410(ccr2)
KABB7C62_31670
KAUB6264_03990
KITCFP65_0766 CFP65_5574
STRIC7M71_024015(ccrA)
YIALO772_11890(ccrA)
ICAIntca_2418
ARSADJ73_15655
JTEASJ30_04335
JLIEXU32_10460(ccrA)
JMEEEW87_010490(ccrA)
TEHGKE56_08395(ccrA)
NCANoca_1795
NDKI601_3892(ccr_1)
NOYEXE57_04975(ccrA)
NOIFCL41_11260(ccrA)
NOOFE634_09285(ccrA)
NSNEXE58_14365(ccrA)
NBEBack2_04340
NANOG5V58_14345(ccrA)
NMESH9L09_15910(ccrA)
NAROCFH99_10030(ccrA)
NPIG7071_11245(ccrA)
NAQUENKNEFLB_01882(ccr_1)
NROK8W59_11035(ccrA)
NOQLN652_20215(ccrA)
PSIMKR76_10630
AERAERYTH_06800
AEZC3E78_12365(ccrA)
AEBC6I20_10340(ccrA)
AEFGEV26_12405(ccrA)
MUZH4N58_06095(ccrA)
KFLKfla_4989
KQIF1D05_07275(ccrA)
NALB005_2057
TCUTcur_4755
ACTWF7P10_02800(ccrA) F7P10_21870(ccrA)
AGRAAGRA3207_004337(ccrA) AGRA3207_007748(ccrA)
SROSros_8814
NOABKM31_49275
NCXNocox_19935(ccr1) Nocox_38800(ccr3)
NGNLCN96_52210(ccrA)
FRAFrancci3_0999 Francci3_3690
FREFranean1_1041 Franean1_3014 Franean1_4051
FRIFraEuI1c_0956 FraEuI1c_3079
FALFRAAL2539(ccrA) FRAAL5913
FSYFsymDg_3826
GOBGobs_4114
BSDBLASA_3898
SACCEYD13_07795(ccr)
AMDAMED_1574(qor)
AMNRAM_07995
AMMAMES_1564(qor)
AMZB737_1565(qor)
AOIAORI_6359(ccr)
AJAAJAP_07605(ccr)
AMQAMETH_5552(qor)
AMYCCU254_06330(ccrA)
AMYBBKN51_25265
AABA4R43_20575
AMYYYIM_09020(ccr1)
AORISD37_08570
AACDLWP59_32235(ccrA)
PDXPsed_1713
PSEAWY02_10715
PSEEFRP1_03485
PSEHXF36_19290
PSEQAD006_11095
PECQAD017_18925
PHHAFB00_04595
PAUTPdca_54450(qor_4)
PBROHOP40_14625(ccrA)
AMIAmir_3664
SESPBN6_73120
SSYIEKG83_15875(ccrA) EKG83_40835(ccrA)
KALKALB_7555
KPHYAOZ06_46110
LEDBBK82_20900
AHMTL08_14615 TL08_14655
ACTIUA75_17085 UA75_17830
ACADUA74_16555 UA74_17295
AHGAHOG_15470(ccr)
ALOCRK58980
PMADBAY61_24435
STPStrop_1018 Strop_3612
SAQSare_3994
MAUMicau_5101
MILML5_3210
MICBMicB006_4119
MTUACSH63_32170(ccrA)
MTEMGCE86_20130(ccrA)
MCABHXZ27_06160(rosM)
ACTNL083_2886
PFLAPflav_056950
PSUUPsuf_000180(qor_1) Psuf_016530 Psuf_046990(qor_4)
CATICS0771_21970(qor_1)
DVCDvina_05675(ccrA) Dvina_07605(ccrA)
CAICaci_1252
SNASnas_4138
EKEEK0264_16515(ccrA)
ABAIIMCC26256_11169
AFOAfer_0105
AYMYM304_37120
ATQGH723_16625(ccrA)
AQZKSP35_14110(ccrA)
IAMHC251_22975(ccrA)
EUZDVS28_a1285
 » show all
Reference
1  [PMID:8521864]
  Authors
Wallace KK, Bao ZY, Dai H, Digate R, Schuler G, Speedie MK, Reynolds KA
  Title
Purification of crotonyl-CoA reductase from Streptomyces collinus and cloning, sequencing and expression of the corresponding gene in Escherichia coli.
  Journal
Eur J Biochem 233:954-62 (1995)
DOI:10.1111/j.1432-1033.1995.954_3.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.86
IUBMB Enzyme Nomenclature: 1.3.1.86
ExPASy - ENZYME nomenclature database: 1.3.1.86
BRENDA, the Enzyme Database: 1.3.1.86
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