KEGG   ENZYME: 1.3.1.89
Entry
EC 1.3.1.89                 Enzyme                                 
Name
tRNA-dihydrouridine47 synthase [NAD(P)+];
Dus3p;
tRNA-dihydrouridine synthase 3
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
tRNA-5,6-dihydrouracil47:NAD(P)+ oxidoreductase
Reaction(IUBMB)
5,6-dihydrouracil47 in tRNA + NAD(P)+ = uracil47 in tRNA + NAD(P)H + H+
Substrate
5,6-dihydrouracil47 in tRNA;
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
uracil47 in tRNA;
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
A flavoenzyme. The enzyme specifically modifies uracil47 in tRNA.
History
EC 1.3.1.89 created 2011
Orthology
K05544  tRNA-dihydrouridine synthase 3
Genes
HSA56931(DUS3L)
PTR739498(DUS3L)
GGO101151804(DUS3L)
PON100431229(DUS3L)
NLE100585707(DUS3L)
MCC719524(DUS3L)
MCF102142821(DUS3L)
CSAB103233747(DUS3L)
CATY105591839(DUS3L)
PANU101022796(DUS3L)
TGE112612683(DUS3L)
RRO104665393(DUS3L)
RBB108512077(DUS3L)
TFN117074495(DUS3L)
PTEH111530844(DUS3L)
CJC100408736(DUS3L)
SBQ101045935(DUS3L)
CSYR103249914(DUS3L)
MMUR105869649(DUS3L)
OGA100966916(DUS3L)
MMU224907(Dus3l)
MCAL110312617(Dus3l)
MPAH110335629(Dus3l)
RNO301122(Dus3l)
MCOC116075090(Dus3l)
MUN110546251(Dus3l)
CGE100760481(Dus3l)
PLEU114688891(Dus3l)
NGI103737197(Dus3l)
HGL101709476(Dus3l)
CPOC100719819(Dus3l)
CCAN109688203(Dus3l)
DORD105990496(Dus3l)
DSP122122844(Dus3l)
OCU100348232(DUS3L)
OPI101524042(DUS3L)
TUP102497152(DUS3L)
CFA100856098(DUS3L)
VVP112935612(DUS3L)
VLG121494822(DUS3L)
AML100468946(DUS3L)
UMR103681858(DUS3L)
UAH113242862(DUS3L)
UAR123779014(DUS3L)
ELK111161874
LLV125088137
MPUF101679541(DUS3L)
ORO101366158(DUS3L)
EJU114226338(DUS3L)
ZCA113918948(DUS3L)
MLX118005273(DUS3L)
FCA101084938(DUS3L)
PYU121021336(DUS3L)
PBG122486761(DUS3L)
PTG102972702(DUS3L)
PPAD109255926(DUS3L)
AJU106975445(DUS3L)
HHV120242108(DUS3L)
BTA508812(DUS3L)
BOM102271270(DUS3L)
BIU109561712(DUS3L)
BBUB102414724(DUS3L)
CHX102181591(DUS3L)
OAS101110760(DUS3L)
ODA120864862(DUS3L)
CCAD122440276(DUS3L)
SSC100513458(DUS3L)
CFR102505239(DUS3L)
CBAI105078243(DUS3L)
CDK105091786(DUS3L)
VPC102528369(DUS3L)
BACU103014038(DUS3L)
LVE103077829(DUS3L)
OOR101275618(DUS3L)
DLE111166097(DUS3L)
PCAD102981752(DUS3L)
PSIU116752196(DUS3L)
EAI106832724(DUS3L)
MYB102247531(DUS3L)
MYD102774570(DUS3L)
MMYO118658788(DUS3L)
MLF102436297(DUS3L)
MNA107525743(DUS3L)
PKL118731243(DUS3L)
DRO112312666(DUS3L)
SHON118984544(DUS3L)
AJM119063783(DUS3L)
PDIC114503533(DUS3L)
PHAS123813829(DUS3L)
MMF118616265(DUS3L)
RFQ117038403(DUS3L)
PALE102882846(DUS3L)
PGIG120615424(DUS3L)
PVP105301068(DUS3L)
RAY107510955(DUS3L)
MJV108389544(DUS3L)
TOD119240614(DUS3L)
SARA101550193(DUS3L)
LAV100677027(DUS3L)
TMU101354264
DNM101411832(DUS3L)
MDO100025142(DUS3L)
GAS123232126(DUS3L)
SHR100923227(DUS3L)
PCW110197460(DUS3L)
OAA100082525(DUS3L)
GGA428339(DUS3L)
PCOC116236119(DUS3L)
MGP100544526(DUS3L)
CJO107325602(DUS3L)
NMEL110388836(DUS3L)
APLA101803268(DUS3L)
ACYG106048415(DUS3L)
AFUL116499206(DUS3L)
TGU101232919(DUS3L)
LSR110478467(DUS3L)
SCAN103824705(DUS3L)
PMOA120499022(DUS3L)
OTC121347406(DUS3L)
PRUF121352669(DUS3L)
GFR102041664(DUS3L)
FAB101812667(DUS3L)
PHI102112645(DUS3L)
PMAJ107215453(DUS3L)
CCAE111940296(DUS3L)
CCW104697413(DUS3L)
ETL114070322(DUS3L)
ZAB102065373(DUS3L)
FPG101923780(DUS3L)
FCH102050218(DUS3L)
CLV102083711(DUS3L)
EGZ104124393(DUS3L)
NNI104018811(DUS3L)
ACUN113489513(DUS3L)
TALA104361305(DUS3L)
PADL103916459(DUS3L)
ACHC115349280(DUS3L)
AAM106500052(DUS3L)
AROW112972319(DUS3L)
NPD112949119(DUS3L)
DNE112989609(DUS3L)
ASN102376845(DUS3L)
AMJ102560014(DUS3L)
CPOO109324947(DUS3L)
GGN109294851(DUS3L)
PSS102444762(DUS3L)
CMY102935238(DUS3L)
CPIC101933640(DUS3L)
TST117868964(DUS3L)
CABI116835885(DUS3L)
MRV120391807(DUS3L)
ACS100553540(dus3l)
PVT110072456(DUS3L)
SUND121937056 121937063(DUS3L) 121937069
PBI103056248(DUS3L)
PMUR107297530(DUS3L)
TSR106554076(DUS3L)
PGUT117656778
VKO123017608(DUS3L)
PMUA114588370(DUS3L)
ZVI118087416(DUS3L)
GJA107120005(DUS3L)
XLA379349(dus3l.L)
XTR394959(dus3l)
NPR108785684(DUS3L)
RTEM120939935(DUS3L)
BBUF121000600(DUS3L)
BGAR122938138(DUS3L)
DRE393647(dus3l)
SRX107712289(dus3l)
SANH107694385(dus3l)
SGH107569919(dus3l)
CCAR109062304 109071143
CAUA113062496 113062497
IPU108274798(dus3l)
PHYP113523890
SMEO124392968(dus3l)
AMEX103038121(dus3l)
EEE113567755(dus3l)
TRU101061502(dus3l)
TNGGSTEN00032548G001
LCO104927572(dus3l)
NCC104962951(dus3l)
CGOB115016189(dus3l)
ELY117263201(dus3l)
PLEP121958260(dus3l)
SLUC116047368(dus3l)
ECRA117956963(dus3l)
PFLV114568118(dus3l)
GAT120826289(dus3l)
PPUG119219245(dus3l)
MSAM119907081(dus3l)
CUD121523256(dus3l)
MZE101487919(dus3l)
ONL100702831(dus3l)
OAU116320037(dus3l)
OLA101158743(dus3l)
OML112148327(dus3l)
XMA102224392(dus3l)
XCO114156490(dus3l)
XHE116731805(dus3l)
PRET103472484(dus3l)
PFOR103146843(dus3l)
PLAI106958642(dus3l)
PMEI106916859(dus3l)
GAF122843116(dus3l)
CVG107103158(dus3l)
CTUL119779646(dus3l)
GMU124879601(dus3l)
NFU107394615(dus3l)
KMR108238118(dus3l)
ALIM106518135(dus3l)
NWH119425918(dus3l)
AOCE111585221(dus3l)
CSEM103394280(dus3l)
POV109638765(dus3l)
SSEN122760929 122786015(dus3l)
HHIP117770884(dus3l)
LCF108879478(dus3l)
SDU111223238(dus3l)
SLAL111657650(dus3l)
XGL120786445(dus3l)
HCQ109512007(dus3l)
BPEC110161134(dus3l)
MALB109958801(dus3l)
SASA100195410(dus3l)
OTW112264693(dus3l)
OMY110496336(dus3l)
OGO124012632(dus3l)
ONE115128482(dus3l)
SALP111955889(dus3l)
SNH120022638(dus3l)
ELS105012658(dus3l)
SFM108933330(dus3l)
PKI111852243(dus3l)
AANG118234288(dus3l)
LOC102685673(dus3l)
PSPA121315011(dus3l)
ARUT117394208 117399648
LCM102347817(DUS3L)
CMK103190441(dus3l)
RTP109910589(dus3l)
BFO118419945
BBEL109467953
CIN100169986(zf(c3h)-5)
SCLV120331711
SPU115926003 588676
APLC110982625
SKO100377501
DMEDmel_CG10463(CG10463)
DER6548935
DSE6614733
DSIDsimw501_GD24232(Dsim_GD24232)
DYADyak_GE13280
DAN6497256
DSR110178702 110181338 110181395
DPODpse_GA10329
DPE6593381
DMN108163199
DWI6642779
DGR6567036
DMODmoj_GI20204
DAZ108611224
DNV108649605
DHE111598908
DVI6628322
CCAT101461465
BOD106617930
MDE101900854
SCAC106081386
LCQ111689705
AGAAgaP_AGAP009171
ACOZ120959581
AARA120901635
AAG5568803
AALB109409261
CQUCpipJ_CPIJ010410
CPII120414074
CNS116337318
AME409969
ACER108003195
ALAB122711526
BIM100749204
BBIF117214371
BVK117242541
BVAN117161143
BTER100642985
BPYO122576611
CCAL108626007
OBB114877852
MGEN117217999
NMEA116425906
CGIG122401228
SOC105194988
MPHA105837805
AEC105155004
ACEP105626879
PBAR105426348
VEM105566823
HST105184979
DQU106749383
CFO105255989
FEX115243765
LHU105669826
PGC109857901
OBO105284470
PCF106788819
PFUC122525165
VPS122627809
NVI100115483
CSOL105360289
TPRE106655116
MDL103580013
CGLO123262172
FAS105268517
DAM107035723
AGIF122858866
CCIN107266365
TCA659320
DPA109537386
SOY115875405
ATD109601781
CSET123311065
AGB108915718
LDC111513584
NVL108557697
APLN108745081
PPYR116181355
OTU111419774
BMOR101735770
BMAN114245859
MSEX115456266
DPLKGM_214117
BANY112058284
PMAC106714278
PPOT106099612
PXU106127604
PRAP110994232
ZCE119840032
HAW110371037
TNL113501001
OFU114357868
API100162121
DNX107162737
AGS114132395
RMD113556397
BTAB109038834
DCI103513175
CLEC106670774
HHAL106691541
NLU111049371
PHUPhum_PHUM335280 Phum_PHUM499910
FOC113211162
ZNE110827735
CSEC111869793
FCD110862545
DPXDAPPUDRAFT_304378
DMK116915771
PVM113820737 113821701
PJA122268154
HAME121879955
PCLA123757311
PTRU123504479
HAZT108672908
EAF111717092
ISCIscW_ISCW009921
DSV119441597
RSAN119386506
RMP119178796
VDE111249259
VJA111263377
TUT107362878
DPTE113789433
DFR124498120
CSCU111620230
PTEP107450347
SDM118202183
CELCELE_Y37E11B.5(Y37E11B.5)
CBRCBG_08326
NAINECAME_02607
TSPTsp_08111
LGILOTGIDRAFT_144742
PCAN112563626
BGT106050820
GAE121381327
HRF124110726
HRJ124281656
CRG105326754
MYI110452916
PMAX117343752
MMER123532978
OBI106882047
OSN115225883
LAK106160940
OVIT265_01957
NVE5514013
EPA110232275
ATEN116301789
AMIL114971765
PDAM113679646
SPIS111344051
DGT114523003
XEN124439743 124440483
HMG100199545
TADTRIADDRAFT_49631
AQU100641100 100641428
ATHAT4G38890
ALY9302895
CRB17880395
CSAT104716167 104727473 104729190
EUSEUTSA_v10024574mg
BRP103860413
BNA106434003 111201311
BOE106317520
RSZ108842141
THJ104824786
CPAP110808209
CIT102621230
CICCICLE_v10027934mg
PVY116143783
MINC123214707
TCC18607673
GRA105766797
GHI107903715 107920288
GAB108463709
DZI111297356 111308801
EGR104453390
GMX100783494
GSJ114408425
PVUPHAVU_009G002300g
VRA106762712
VAR108331987
VUN114164684
CCAJ109802550
APRC113864438
MTRMTR_3g117580
CAM101506864
LJALj1g3v3354300.1(Lj1g3v3354300.1) Lj1g3v3354300.2(Lj1g3v3354300.2)
ADU107460306
AIP107609100
AHF112705779 112764135
LANG109326897
FVE101297891
RCN112172969
PPER18766784
PMUM103335589
PAVI110750338
MDM103445154
PXB103938792 103966948
ZJU107426709
MNT21395474
CSV101215945
CMO103490332
BHJ120078469
MCHA111007837
CMAX111468431
CMOS111455351
CPEP111811451
RCU8284388
JCU105643823
HBR110635460
MESC110626785
POP7494292
PEU105141560
PALZ118058985
JRE108986972
QSU111995727 112005877 112027713
QLO115968347
TWL119990375 120001636 120002129
VVI100262408
VRI117910889
SLY101268622
SPEN107007930
SOT102598558
CANN107840492
NTA107766363 107782150
NSY104219352
NTO104104650
NAU109213279
INI109154087
ITR115999787
SIND105169744
OEU111410107
EGT105957734
SSPL121747972 121752042
HAN110926282
ECAD122585950
LSV111903730
CCAV112526036
DCR108192980
CSIN114267315 114278563
BVG104883109
SOE110787720
CQI110705201 110718854
NNU104602061
MING122084551
TSS122658630
PSOM113288809 113289814
NCOL116248834
OSA4334955
DOSAOs04t0117600-01(Os04g0117600)
OBR102722112
BDI100840789
ATS109760365
TDC119352663 119361678
TAES123043074 123050965 123186928
SBI8080272
ZMA100279244
SITA101756688
SVS117864013
PVIR120639634 120681924
PHAI112900054
PDA103701488
EGU105044135
MUS103983045
DCT110115784
PEQ110029492
AOF109837426
ATR18442714
SMOSELMODRAFT_267436 SELMODRAFT_409324 SELMODRAFT_89139
PPP112281898
VCNVOLCADRAFT_105302
MNGMNEG_0739 MNEG_5928
CSLCOCSUDRAFT_19841
CVRCHLNCDRAFT_140504 CHLNCDRAFT_25754
APROF751_1206
OLUOSTLU_1214 OSTLU_86070
OTAOT_ostta01g01750 OT_ostta10g01740 OT_ostta12g02890
BPGBathy01g01600 Bathy09g04430 Bathy11g01730
MISMICPUN_56024 MICPUN_66278 MICPUN_99494
MPPMICPUCDRAFT_11009 MICPUCDRAFT_16983 MICPUCDRAFT_17474
GSLGasu_08660
CCPCHC_T00007932001
SCEYLR401C(DUS3)
AGOAGOS_AER070C
ERCEcym_3254
KLAKLLA0_B03069g
KMXKLMA_40458(DUS3)
LTHKLTH0D14696g
VPOKpol_483p21
ZROZYRO0B12716g
CGRCAGL0M09977g
NCSNCAS_0J01580(NCAS0J01580)
NDINDAI_0J02350(NDAI0J02350)
TPFTPHA_0B00720(TPHA0B00720)
TBLTBLA_0I03030(TBLA0I03030)
TDLTDEL_0E01060(TDEL0E01060)
TGBHG536_0E01850
KAFKAFR_0A05860(KAFR0A05860)
ZMKHG535_0B06580
PPAPAS_chr4_0178
DHADEHA2D11286g
PICPICST_83606(DUS3)
PGUPGUG_00726
SPAASPAPADRAFT_60480
LELLELG_00757
CALCAALFM_C202420CA(CaO19.1565)
CTPCTRG_01391
COTCORT_0A10260
CDUCD36_17170
CTENCANTEDRAFT_100359
YLIYALI0E26048g
CLUCLUG_00141
CLUSA9F13_20g00704
CAURCJI97_003716
SLBAWJ20_836(DUS3)
PKZC5L36_0A03940
BNNFOA43_001809
BBRXBRETT_004693
NCRNCU02619
NTENEUTE1DRAFT126438(NEUTE1DRAFT_126438)
SMPSMAC_05742
PANPODANSg09694
TTTTHITE_2121449
MTMMYCTH_2294623
CTHRCTHT_0058200
MGRMGG_01205
TMNUCRPA7_5931
SSCKSPSK_08590
FGRFGSG_00665
FPUFPSE_00637
FVRFVEG_00530
FOXFOXG_00984
NHENECHADRAFT_75304
TRETRIREDRAFT_109015
TRRM419DRAFT_131276
MAWMAC_06225
MAJMAA_00740
CMTCCM_05402
PLJVFPFJ_09152
VALVDBG_07353
VDAVDAG_06058
CFJCFIO01_10686
SAPOSAPIO_CDS1426
ELAUCREL1_7587
PFYPFICI_13664
SSLSS1G_05865
BFUBCIN_05g02250(Bcdus3)
MBEMBM_03504
PSCOLY89DRAFT_713139
GLZGLAREA_08076
ANIAN0818.2
AFMAFUA_1G14770
ACTACLA_020610
NFINFIA_010640
AORAO090003000505
ANGANI_1_1738014(An01g12800)
AFVAFLA_001185
ALUCAKAW2_10340A(DUS3)
ACHEACHE_30615A(DUS3)
APUUAPUU_51000A(DUS3)
PCSPc16g13720
PDPPDIP_66090
TMFPMAA_074000
TRGTRUGW13939_09064
CIMCIMG_03259
CPWCPC735_009210
UREUREG_07107
PBLPAAG_05442
PBNPADG_12183(PADG_06792)
ABEARB_01907
TVETRV_02123
AJEHCAG_02383
BGHBDBG_08418
PNOSNOG_11628
PTEPTT_06777
BZECOCCADRAFT_29232
BSCCOCSADRAFT_100973
BORCOCMIDRAFT_3299
AALTCC77DRAFT_463405
ZTRMYCGRDRAFT_65640
PFJMYCFIDRAFT_153683
BCOMBAUCODRAFT_58554
NPAUCRNP2_3550
TMLGSTUM_00006564001 GSTUM_00008939001
SPOSPAC16.04(dus3)
CNECNI00050
CNBCNBH0060
CGICGB_H0450W
TMSTREMEDRAFT_68591
TASAA1Q1_02606
TVSTRAVEDRAFT_133692
DSQDICSQDRAFT_105612
SHSSTEHIDRAFT_96778
HIRHETIRDRAFT_156632
PSQPUNSTDRAFT_57398
ADLAURDEDRAFT_111541
FMEFOMMEDRAFT_168578
GTRGLOTRDRAFT_80968
LBCLACBIDRAFT_184083
MRRMoror_4173
CCICC1G_12476
SCMSCHCODRAFT_82562
ABPAGABI1DRAFT60503(AGABI1DRAFT_60503)
ABVAGABI2DRAFT187624(AGABI2DRAFT_187624)
CPUTCONPUDRAFT_145072
SLASERLADRAFT_347999
UMAUMAG_05921
PFPPFL1_02664
MGLMGL_0420
MRTMRET_2242
MSYMMSY001_1420
MLRMELLADRAFT_48857
MBRMONBRDRAFT_15444
SREPTSG_02176
DDIDDB_G0292686(dus3l)
DPPDICPUDRAFT_31125
DFADFA_03618(dus3l)
EHIEHI_140340(150.t00019)
EDIEDI_043290
EIVEIN_345770
ACANACA1_031670 ACA1_384000
CPVcgd5_2440
CHOChro.50134
TGOTGME49_228080
SMINv1.2.017108.t1(symbB.v1.2.017108.t1) v1.2.040733.t1(symbB.v1.2.040733.t1)
PTIPHATRDRAFT_13664
FCYFRACYDRAFT_158848
TPSTHAPSDRAFT_32996
AAFAURANDRAFT_1138
PIFPITG_02557
PSOJPHYSODRAFT_324006
SPARSPRG_08593
EHXEMIHUDRAFT_251582 EMIHUDRAFT_428642
GTTGUITHDRAFT_158684
TBRTb927.7.6450
TBGTbgDal_VII7460
TCR510053.70 511321.20
LMALMJF_17_0350
LIFLINJ_17_0400
LDOLDBPK_170400
LMILMXM_17_0350
LBZLBRM_17_0330
LPANLPMP_170310
GLAGL50803_003565
ABACLuPra_03129(dus_1)
 » show all
Reference
1  [PMID:14970222]
  Authors
Xing F, Hiley SL, Hughes TR, Phizicky EM
  Title
The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs.
  Journal
J Biol Chem 279:17850-60 (2004)
DOI:10.1074/jbc.M401221200
  Sequence
[sce:YLR401C]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.89
IUBMB Enzyme Nomenclature: 1.3.1.89
ExPASy - ENZYME nomenclature database: 1.3.1.89
BRENDA, the Enzyme Database: 1.3.1.89
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