Entry
Name
very-long-chain enoyl-CoA reductase;
TSC13 (gene name);
CER10 (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
very-long-chain acyl-CoA:NADP+ oxidoreductase
Reaction(IUBMB)
a very-long-chain acyl-CoA + NADP+ = a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH + H+ [RN:
R10828 ]
Reaction(KEGG)
Substrate
Product
very-long-chain trans-2,3-dehydroacyl-CoA [CPD:
C20879 ];
NADPH [CPD:
C00005 ];
H+ [CPD:
C00080 ]
Comment
This is the fourth component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. cf. EC
2.3.1.199 , very-long-chain 3-oxoacyl-CoA synthase, EC
1.1.1.330 , very-long-chain 3-oxoacyl-CoA reductase, and EC
4.2.1.134 , very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase.
History
EC 1.3.1.93 created 2012
Pathway
ec01040 Biosynthesis of unsaturated fatty acids
ec01110 Biosynthesis of secondary metabolites
Orthology
K10258 very-long-chain enoyl-CoA reductase
Genes
PTEH : 111546248 111554381(TECR) 113222062
RNO : 191576(Tecr) 499018(RGD1560015)
PPAD : 109247758 109253922(TECR)
SARA : 101543878 101557823(TECR)
MDO : 100026440(TECR) 100032861
SHR : 100914010(TECR) 116423386
PCW : 110197969 110203436(TECR)
OAA : 100080249 100081999(TECR)
GGA : 107050163 424491(TECR)
PCOC : 116238972(TECR) 116243504
PMOA : 120508662 120510871
PRUF : 121362023 121363358
PHI : 102099600(TECR) 106628096
CCAE : 111922653(TECR) 111932652
ACHC : 115348278 115348983
ASN : 102370679(TECR) 102383204
AMJ : 102559187(TECR) 102575131
PSS : 102457301(TECR) 102459125
CMY : 102929357(TECR) 102931932
CPIC : 101937001(TECR) 101945886
TST : 117881252 117888503(TECR)
CABI : 116820507 116825406(TECR)
MRV : 120370281 120391408(TECR)
ACS : 100560578 100566730(tecr)
PVT : 110070802(TECR) 110076484
SUND : 121921198(TECR) 121928617
PBI : 103058993 103065171(TECR)
PMUR : 107292471(TECR) 107295608
PGUT : 117659321(TECR) 117677238
VKO : 123024554 123035425(TECR)
PMUA : 114590788(TECR) 114598728
ZVI : 118079968(TECR) 118088377
GJA : 107112228 107117643(TECR)
XLA : 108713542(MGC146850.L) 380153(tecr.L) 444160(tecr.S)
XTR : 493561(tecr) 780081(MGC146850)
NPR : 108789250 108797751(TECR)
RTEM : 120933242(TECR) 120945671
BBUF : 120978502 120986215(TECR)
BGAR : 122927358 122927359 122943401
DRE : 326954(tecrb) 450002(tecrl2b) 566085(tecra) 798606(tecrl2a)
SRX : 107711203 107714113 107729653 107745691 107747144(tecr)
SANH : 107661839 107670448 107680044 107694603 107697782 107703756
SGH : 107564537 107573605 107594239 107599304 107602715
CCAR : 109063766 109080996 109103830 109106768
CAUA : 113042176 113051426 113066137 113067679 113074513 113097128 113115733
IPU : 100528865(tecrb) 108255190(tecrl2a) 108256782(tecra)
PHYP : 113524968 113537422(tecr) 113546295 113547559
SMEO : 124376328(tecra) 124378407(tecrb) 124384339(tecrl2a) 124402984(tecrl2b)
AMEX : 103029998 103040826 103043316 103047753(tecr)
EEE : 113584545 113590736 113592021(tecr)
TRU : 101061272 101070143(tecr) 101076261
TNG : GSTEN00016634G001 GSTEN00026306G001
CGOB : 115009472(tecr) 115011694 115025451
ELY : 117255374(tecrb) 117264704 117268496(tecra)
PLEP : 121956431(tecra) 121960674
SLUC : 116042814(tecrb) 116055761 116059458(tecra)
ECRA : 117937872 117958745(tecra) 117959246(tecrb)
PFLV : 114549393 114565710(tecr) 114568924
GAT : 120811678 120825752(tecrb) 120827143(tecra)
PPUG : 119198318 119217402(tecrb) 119220462(tecra)
MSAM : 119896514(tecra) 119899464(tecrb) 119907318
CUD : 121503681(tecra) 121508514(tecrb) 121527467
MZE : 101469805 101471785 101483996(tecr)
ONL : 100699909 100701654(tecr) 100710535
OAU : 116310621(tecrb) 116317697(tecra) 116335763
OLA : 101155407(tecr) 101163495 101171706
OML : 112137470(tecrb) 112146832(tecra) 112151473
XMA : 102220976 102224233 102224945(tecr)
XCO : 114136676 114144650(tecr) 114159783
XHE : 116711637 116720152(tecr) 116735325
PRET : 103461133(tecr) 103482281
PFOR : 103143338 103143372 103151989 103154161(tecr)
PLAI : 106945992(tecr) 106958234 106963585
PMEI : 106914552 106922055(tecr) 106932487
GAF : 122821457(tecra) 122824237(tecrl2a) 122829703(tecrb)
CVG : 107084911 107093427 107094408(tecr)
CTUL : 119794849(tecra) 119795985 119798025(tecrb)
GMU : 124857930(tecrl2a) 124862898 124864986 124868154(tecrb)
KMR : 108241336(tecra) 108241483(tecrb)
ALIM : 106529633 106530387(tecr)
NWH : 119421720(tecra) 119422775(tecrb)
AOCE : 111569904(tecr) 111573670 111574563
CSEM : 103377076 103383916(tecr) 103392722
POV : 109627729(tecr) 109629827 109634303
SSEN : 122771204(tecrb) 122772526(tecrl2a) 122785720(tecra)
HHIP : 117753845 117765698(tecra) 117769039(tecrb)
LCF : 108885426(tecr) 108902677
SDU : 111227218 111228193 111229346(tecr)
SLAL : 111648242 111653695 111665569(tecr)
XGL : 120788205(tecra) 120789966 120800507(tecrb)
HCQ : 109521419 109527436(tecr)
BPEC : 110165444 110166151 110169504
MALB : 109952401(tecr) 109966006
SASA : 106564267(tecr) 106569794 106590656
OTW : 112215531 112260940 121841110
OMY : 110485397(tecrb) 110486719 110489543 110530851 110535481 110538672
OGO : 123990210(tecrl2a) 123998942 124003155(tecrb) 124009868 124015393 124019190 124039094
ONE : 115104342 115114041 115120682 115123622
SALP : 111972518 112071494 112073603
SNH : 120027677 120034433 120040317(tecrb) 120041688 120044634 120050274
ELS : 105010434 105013088 105022597 105029730(tecr)
PKI : 111840958 111849227 111849411
AANG : 118219786(tecrb) 118225720
LOC : 102686016 102686340(tecr)
PSPA : 121304508(tecrb) 121326563 121330590
ARUT : 117402162(tecrb) 117408311 117417360 117962766
DSI : Dsimw501_GD13786(Dsim_GD13786)
AALB : 109418540 115257884
BTAB : 109042406 109044523
EAF : 111708945 111718244 111718258
DPTE : 113796694 113799520
CBR : CBG_11196(Cbr-art-1)
CSAT : 104781415 104791824
MINC : 123192664 123228367
GHI : 107904734 107934412 107959873 121207779
MCHA : 111006458 111013716
CMAX : 111487465 111489004
CMOS : 111429991 111444958
MESC : 110619378 110624009
PALZ : 118052410 118059725
QSU : 111987111 112014784 112027661
NTA : 107785715 107796650(ER)
HAN : 110872584 110904732 110913412
CCAV : 112520649 112525420
PSOM : 113313744 113322500 113345081
DOSA : Os01t0150000-01(Os01g0150000)
TAES : 123060149 123068633 123077157
PVIR : 120672887 120705981
PEQ : 110022982 110024888 110024890
SMO : SELMODRAFT_186154 SELMODRAFT_270920
NCS : NCAS_0I01880(NCAS0I01880)
NDI : NDAI_0A06480(NDAI0A06480)
TPF : TPHA_0A04340(TPHA0A04340)
TBL : TBLA_0B01660(TBLA0B01660)
TDL : TDEL_0D04380(TDEL0D04380)
KAF : KAFR_0F02320(KAFR0F02320)
LEL : LELG_01381 LELG_05600
CAL : CAALFM_C101050CA(CaO19.3293)
NTE : NEUTE1DRAFT117529(NEUTE1DRAFT_117529)
AOR : AO090003001139 AO090038000096
ANG : ANI_1_968184(An04g05930)
AFV : AFLA_000527 AFLA_012367
ALUC : AKAW2_51558S(TSC13)
PNO : SNOG_07392(SNOG_07391)
ADL : AURDEDRAFT_105341 AURDEDRAFT_152816
EHI : EHI_045030(3.t00089) EHI_076870(40.t00027)
EDI : EDI_220060 EDI_292090
PCB : PCHAS_071400(PC000427.01.0)
BBO : BBOV_III001830(17.m10668)
PTM : GSPATT00012181001 GSPATT00013728001
» show all
Taxonomy
Reference
Authors
Kohlwein SD, Eder S, Oh CS, Martin CE, Gable K, Bacikova D, Dunn T
Title
Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae.
Journal
Sequence
Reference
Authors
Gable K, Garton S, Napier JA, Dunn TM
Title
Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system.
Journal
Sequence
Reference
Authors
Kvam E, Gable K, Dunn TM, Goldfarb DS
Title
Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles.
Journal
Sequence
Reference
Authors
Zheng H, Rowland O, Kunst L
Title
Disruptions of the Arabidopsis Enoyl-CoA reductase gene reveal an essential role for very-long-chain fatty acid synthesis in cell expansion during plant morphogenesis.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.93
ExPASy - ENZYME nomenclature database: 1.3.1.93
LinkDB
All DBs