KEGG   ENZYME: 1.3.4.1
Entry
EC 1.3.4.1                  Enzyme                                 

Name
fumarate reductase (CoM/CoB);
thiol:fumarate reductase;
Tfr
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a disulfide as acceptor
Sysname
fumarate CoM:CoB oxidoreductase (succinate-forming)
Reaction(IUBMB)
fumarate + CoM + CoB = succinate + CoM-S-S-CoB [RN:R10660]
Reaction(KEGG)
R10660
Substrate
fumarate [CPD:C00122];
CoM [CPD:C03576];
CoB [CPD:C04628]
Product
succinate [CPD:C00042];
CoM-S-S-CoB [CPD:C04832]
Comment
The enzyme, isolated from the archaeon Methanobacterium thermoautotrophicum, is very oxygen sensitive. It cannot use reduced flavins, reduced coenzyme F420, or NAD(P)H as an electron donor. Distinct from EC 1.3.1.6 [fumarate reductase (NADH)], EC 1.3.5.1 [succinate dehydrogenase (ubiquinone)], and EC 1.3.5.4 [fumarate reductase (quinol)].
History
EC 1.3.4.1 created 2014 as EC 1.3.98.2, transferred 2014 to EC 1.3.4.1
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18209  fumarate reductase (CoM/CoB) subunit A
K18210  fumarate reductase (CoM/CoB) subunit B
Genes
LCJ: NCTC11976_02789(nadB_2)
BGE: BC1002_5768
BFN: OI25_7370
PSPW: BJG93_06520
PPUL: RO07_01465
PSPU: NA29_12930
PNR: AT302_16660
SLAC: SKTS_06150
CSPF: CSF_1076
DMS: E8L03_00165
SPHI: TS85_13175
BACO: OXB_3153
DSY: DSY3532
DHD: Dhaf_1873
ATE: Athe_2084
FMA: FMG_0304
STED: SPTER_31650(nadB)
NCA: Noca_0032
ELE: Elen_0252
BIP: Bint_2001
MMP: MMP1067 MMP1277(frdA)
MMD: GYY_06170 GYY_07220(sdhA)
MMAK: MMKA1_12460(tfrB) MMKA1_15020(tfrA)
MMAO: MMOS7_11760(tfrB) MMOS7_13840(tfrA)
MMAD: MMJJ_15680(frdA) MMJJ_17830(frdB)
MMG: MTBMA_c00880(tfrA) MTBMA_c04210(tfrB)
MWO: MWSIV6_0043(tfrA) MWSIV6_0381(tfrB)
METE: tca_01449(nadB) tca_01787(frdB)
MST: Msp_0180(tfrA) Msp_1044(tfrB)
MRU: mru_0088(sdhA) mru_0655(sdhB) mru_1212(hdrB2)
MEB: Abm4_0015(sdhA) Abm4_1340(sdhB)
MMIL: sm9_0007(sdhA) sm9_0612(sdhB)
MEYE: TL18_00105(sdhA) TL18_02920
MFC: BRM9_0092(sdhA) BRM9_0542(sdhB)
MCUB: MCBB_0053(tfrA) MCBB_1554
MKA: MK0132(frdB_glpC) MK0498 MK0828(sdhA)
FPL: Ferp_1387
TGA: TGAM_1022
TSI: TSIB_0772
THE: GQS_01385
PPAC: PAP_08545
MBAR: MSBR2_0046
MBAK: MSBR3_0027
MMA: MM_1290
MMAC: MSMAC_0025
METM: MSMTP_0027
MTHR: MSTHT_1799
MTHE: MSTHC_1487
MHOR: MSHOH_0025
MMH: Mmah_1949
MPY: Mpsy_1801
MTP: Mthe_1652
MCJ: MCON_3042(hdrD)
MHI: Mhar_0709
MBG: BN140_0102(sdhB) BN140_0103(sdhA)
MPD: MCP_0282(hdrD-1) MCP_1107(hdrD-2)
 » show all
Reference
1  [PMID:2499256]
  Authors
Khandekar SS, Eirich LD
  Title
Purification and characterization of an anabolic fumarate reductase from Methanobacterium thermoautotrophicum.
  Journal
Appl Environ Microbiol 55:856-61 (1989)
DOI:10.1128/AEM.55.4.856-861.1989
Reference
2  [PMID:9578488]
  Authors
Heim S, Kunkel A, Thauer RK, Hedderich R
  Title
Thiol:fumarate reductase (Tfr) from Methanobacterium thermoautotrophicum--identification of the catalytic sites for fumarate reduction and thiol oxidation.
  Journal
Eur J Biochem 253:292-9 (1998)
DOI:10.1046/j.1432-1327.1998.2530292.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.4.1
IUBMB Enzyme Nomenclature: 1.3.4.1
ExPASy - ENZYME nomenclature database: 1.3.4.1
BRENDA, the Enzyme Database: 1.3.4.1
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