KEGG   ENZYME: 1.3.8.9Help
Entry
EC 1.3.8.9                  Enzyme                                 

Name
very-long-chain acyl-CoA dehydrogenase;
ACADVL (gene name).
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
BRITE hierarchy
Sysname
very-long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Reaction(IUBMB)
a very-long-chain acyl-CoA + electron-transfer flavoprotein = a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Reaction(KEGG)
(other) R01279 R03990
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Substrate
very-long-chain acyl-CoA [CPD:C20876];
electron-transfer flavoprotein [CPD:C04253]
Product
very-long-chain trans-2,3-dehydroacyl-CoA [CPD:C20879];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme is most active toward long-chain acyl-CoAs such as C14, C16 and C18, but is also active with very-long-chain acyl-CoAs up to 24 carbons. It shows no activity for substrates of less than 12 carbons. Its specific activity towards palmitoyl-CoA is more than 10-fold that of the long-chain acyl-CoA dehydrogenase [1]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.8, long-chain acyl-CoA dehydrogenase.
History
EC 1.3.8.9 created 1961 as EC 1.3.2.2, transferred 1964 to EC 1.3.99.3, part transferred 2012 to EC 1.3.8.9
Pathway
ec00071  Fatty acid degradation
ec01100  Metabolic pathways
Orthology
K09479  very long chain acyl-CoA dehydrogenase
Genes
HSA: 37(ACADVL)
PTR: 455237(ACADVL)
PPS: 100986379(ACADVL)
GGO: 101143346(ACADVL)
PON: 100454381(ACADVL)
NLE: 100585921(ACADVL)
MCC: 714326(ACADVL)
CSAB: 103242278(ACADVL)
RRO: 104673335(ACADVL)
RBB: 108514298(ACADVL)
CJC: 100399197(ACADVL)
SBQ: 101028298(ACADVL)
MMU: 11370(Acadvl)
MCAL: 110304163(Acadvl)
MPAH: 110332221(Acadvl)
RNO: 25363(Acadvl)
MUN: 110555097(Acadvl)
CGE: 100767527(Acadvl)
NGI: 103752159(Acadvl)
HGL: 101707761(Acadvl)
CCAN: 109674520(Acadvl)
OCU: 100346654(ACADVL)
TUP: 102486032(ACADVL)
CFA: 489463(ACADVL)
VVP: 112912949 112924990(ACADVL)
AML: 100472785(ACADVL)
UMR: 103660348(ACADVL)
UAH: 113271108(ACADVL)
ORO: 101376612(ACADVL)
FCA: 101094144(ACADVL)
PTG: 102968012(ACADVL)
PPAD: 109245981(ACADVL)
AJU: 106972414(ACADVL)
BTA: 282130(ACADVL)
BIU: 109573934(ACADVL)
BBUB: 102405745(ACADVL)
CHX: 102181987(ACADVL)
OAS: 101117173(ACADVL)
SSC: 100520636(ACADVL)
CFR: 102516576(ACADVL)
CDK: 105103048(ACADVL)
BACU: 103000307(ACADVL)
LVE: 103077095(ACADVL)
OOR: 101275668(ACADVL)
DLE: 111185665(ACADVL)
PCAD: 102973774(ACADVL)
ECB: 100061583(ACADVL)
EPZ: 103557744(ACADVL)
EAI: 106844174(ACADVL)
MYB: 102257348(ACADVL)
MYD: 102774563(ACADVL)
MNA: 107544584(ACADVL)
HAI: 109394616(ACADVL)
DRO: 112308631(ACADVL)
PALE: 102879612(ACADVL)
RAY: 107509515(ACADVL)
MJV: 108401220(ACADVL)
LAV: 100657276(ACADVL)
TMU: 101361348
MDO: 100016619(ACADVL)
SHR: 100925698 100931501(ACADVL)
PCW: 110193114 110194404(ACADVL)
OAA: 100089853(ACADVL)
LSR: 110482134(ACADVL)
CCAE: 111922435(ACADVL)
AAM: 106485823(ACADVL)
ASN: 102371669 102384902(ACADVL)
AMJ: 102568802(ACADVL) 102576922
PSS: 102443861(ACADVL) 102456803
CMY: 102938508(ACADVL)
CPIC: 101946768 101948805(ACADVL)
PVT: 110082312(ACADVL)
PBI: 103051941 103059781(ACADVL)
PMUR: 107291707 107295343(ACADVL)
TSR: 106542417(ACADVL) 106551584
PMUA: 114581599(ACADVL) 114598214
GJA: 107118083(ACADVL) 107125630
XLA: 108711808(acadvl.L)
DRE: 573723(acadvl)
SANH: 107675499 107683542(acadvl)
IPU: 108267840(acadvl)
PHYP: 113540141(acadvl)
AMEX: 103045531(acadvl)
EEE: 113567683(acadvl)
TRU: 101069830(acadvl)
LCO: 104937817(acadvl)
MZE: 101472773(acadvl)
ONL: 100703037(acadvl)
OLA: 101165349(acadvl)
XMA: 102217028(acadvl)
XCO: 114157390(acadvl)
PRET: 103480485(acadvl)
CVG: 107087781(acadvl)
NFU: 107372430(acadvl)
KMR: 108241814(acadvl)
ALIM: 106529201(acadvl)
AOCE: 111575585(acadvl)
CSEM: 103386901(acadvl)
POV: 109634887(acadvl)
LCF: 108897054(acadvl)
SDU: 111232992(acadvl)
SLAL: 111665745(acadvl)
HCQ: 109506947(acadvl)
BPEC: 110157677(acadvl)
MALB: 109966474(acadvl)
SASA: 106602820(acadvl)
OTW: 112216747
SALP: 111950426(acadvl)
ELS: 105010800(acadvl)
SFM: 108918781(acadvl) 108923151
PKI: 111860921(acadvl)
LCM: 102364546(ACADVL)
RTP: 109912656 109918899(acadvl)
CIN: 100183990
SPU: 584710
APLC: 110981027
SKO: 100369524
DME: Dmel_CG7461(CG7461)
DER: 6547331
DSI: Dsimw501_GD11444(Dsim_GD11444)
DSR: 110177854
DPE: 6602657
DWI: 6651878
DAZ: 108614533
DNV: 108651701
DHE: 111592309
MDE: 101891231
LCQ: 111683088
AME: 412025
BIM: 100747671
BTER: 100651720
CCAL: 108632159
OBB: 114874036
SOC: 105200554
MPHA: 105838446
AEC: 105149521
ACEP: 105622411
PBAR: 105429882
VEM: 105562928
HST: 105188087
DQU: 106746266
CFO: 105251587
LHU: 105667331
PGC: 109854598
OBO: 105276471
PCF: 106788263
NVI: 100116828
CSOL: 105368265
MDL: 103574466
TCA: 659957
DPA: 109541041
ATD: 109601372
BMOR: 101744941
PMAC: 106710891
PRAP: 110996061
HAW: 110380632
TNL: 113500974
API: 100162051
DNX: 107164135
RMD: 113560282
BTAB: 109036499
CLEC: 106668658
ZNE: 110832869
FCD: 110843829
TUT: 107362076
DPTE: 113799491
CSCU: 111630174
PTEP: 107450301
CEL: CELE_E04F6.5(acdh-12)
CBR: CBG13088
BMY: Bm1_24055
TSP: Tsp_10283
PCAN: 112555772
CRG: 105344745
MYI: 110463202
OBI: 106875659
EPA: 110251159
ADF: 107343075
PDAM: 113681975
SPIS: 111335626
DGT: 114521443
HMG: 100201063
AQU: 100638454
 » show all
Taxonomy
Reference
1  [PMID:1730632]
  Authors
Izai K, Uchida Y, Orii T, Yamamoto S, Hashimoto T
  Title
Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase.
  Journal
J Biol Chem 267:1027-33 (1992)
  Sequence
[rno:25363]
Reference
2  [PMID:7769092]
  Authors
Aoyama T, Souri M, Ushikubo S, Kamijo T, Yamaguchi S, Kelley RI, Rhead WJ, Uetake K, Tanaka K, Hashimoto T
  Title
Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients.
  Journal
J Clin Invest 95:2465-73 (1995)
DOI:10.1172/JCI117947
  Sequence
[hsa:37]
Reference
3  [PMID:18227065]
  Authors
McAndrew RP, Wang Y, Mohsen AW, He M, Vockley J, Kim JJ
  Title
Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase.
  Journal
J Biol Chem 283:9435-43 (2008)
DOI:10.1074/jbc.M709135200
  Sequence
[hsa:37]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.9
IUBMB Enzyme Nomenclature: 1.3.8.9
ExPASy - ENZYME nomenclature database: 1.3.8.9
BRENDA, the Enzyme Database: 1.3.8.9
LinkDB All DBs

DBGET integrated database retrieval system