EC                  Enzyme                                 

very-long-chain acyl-CoA dehydrogenase;
ACADVL (gene name).
Acting on the CH-CH group of donors;
With a flavin as acceptor
very-long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
a very-long-chain acyl-CoA + electron-transfer flavoprotein = a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
(other) R01279 R03990
very-long-chain acyl-CoA [CPD:C20876];
electron-transfer flavoprotein [CPD:C04253]
very-long-chain trans-2,3-dehydroacyl-CoA [CPD:C20879];
reduced electron-transfer flavoprotein [CPD:C04570]
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme is most active toward long-chain acyl-CoAs such as C14, C16 and C18, but is also active with very-long-chain acyl-CoAs up to 24 carbons. It shows no activity for substrates of less than 12 carbons. Its specific activity towards palmitoyl-CoA is more than 10-fold that of the long-chain acyl-CoA dehydrogenase [1]. cf. EC, short-chain acyl-CoA dehydrogenase, EC, medium-chain acyl-CoA dehydrogenase, and EC, long-chain acyl-CoA dehydrogenase.
EC created 1961 as EC, transferred 1964 to EC, part transferred 2012 to EC
ec00071  Fatty acid degradation
ec01100  Metabolic pathways
K09479  very long chain acyl-CoA dehydrogenase
PTR: 455237(ACADVL)
PPS: 100986379(ACADVL)
GGO: 101143346(ACADVL)
PON: 100454381(ACADVL)
NLE: 100585921(ACADVL)
MCC: 714326(ACADVL)
CSAB: 103242278(ACADVL)
RRO: 104673335(ACADVL)
RBB: 108514298(ACADVL)
CJC: 100399197(ACADVL)
SBQ: 101028298(ACADVL)
MMU: 11370(Acadvl)
MCAL: 110304163(Acadvl)
MPAH: 110332221(Acadvl)
RNO: 25363(Acadvl)
MUN: 110555097(Acadvl)
CGE: 100767527(Acadvl)
NGI: 103752159(Acadvl)
HGL: 101707761(Acadvl)
CCAN: 109674520(Acadvl)
OCU: 100346654(ACADVL)
TUP: 102486032(ACADVL)
CFA: 489463(ACADVL)
VVP: 112924990(ACADVL)
AML: 100472785(ACADVL)
UMR: 103660348(ACADVL)
UAH: 113271108(ACADVL)
ORO: 101376612(ACADVL)
ELK: 111161073
FCA: 101094144(ACADVL)
PTG: 102968012(ACADVL)
PPAD: 109245981(ACADVL)
AJU: 106972414(ACADVL)
BTA: 282130(ACADVL)
BOM: 102273950
BIU: 109573934(ACADVL)
BBUB: 102405745(ACADVL)
CHX: 102181987(ACADVL)
OAS: 101117173(ACADVL)
SSC: 100520636(ACADVL)
CFR: 102516576(ACADVL)
CDK: 105103048(ACADVL)
BACU: 103000307(ACADVL)
LVE: 103077095(ACADVL)
OOR: 101275668(ACADVL)
DLE: 111185665(ACADVL)
PCAD: 102973774(ACADVL)
ECB: 100061583(ACADVL)
EPZ: 103557744(ACADVL)
EAI: 106844174(ACADVL)
MYB: 102257348(ACADVL)
MYD: 102774563(ACADVL)
MNA: 107544584(ACADVL)
HAI: 109394616(ACADVL)
DRO: 112308631(ACADVL)
PALE: 102879612(ACADVL)
RAY: 107509515(ACADVL)
MJV: 108401220(ACADVL)
LAV: 100657276(ACADVL)
TMU: 101361348
MDO: 100016619(ACADVL) 100032148
SHR: 100925698 100931501(ACADVL)
PCW: 110193114 110194404(ACADVL)
OAA: 100089853(ACADVL)
LSR: 110482134(ACADVL)
CCAE: 111922435(ACADVL)
AAM: 106485823(ACADVL)
ASN: 102371669 102384902(ACADVL)
AMJ: 102568802(ACADVL) 102576922
PSS: 102443861(ACADVL) 102456803
CMY: 102938508(ACADVL)
CPIC: 101946768 101948805(ACADVL)
PVT: 110082312(ACADVL)
PBI: 103051941 103059781(ACADVL)
PMUR: 107291707 107295343(ACADVL)
TSR: 106542417(ACADVL) 106551584
PMUA: 114581599(ACADVL) 114598214
GJA: 107118083(ACADVL) 107125630
XLA: 108711808(acadvl.L)
XTR: 100216267(acadvl)
DRE: 573723(acadvl)
SANH: 107675499 107683542(acadvl)
IPU: 108267840(acadvl)
PHYP: 113540141(acadvl)
AMEX: 103045531(acadvl)
EEE: 113567683(acadvl)
TRU: 101069830(acadvl)
LCO: 104937817(acadvl)
NCC: 104942951
MZE: 101472773(acadvl)
ONL: 100703037(acadvl)
OLA: 101165349(acadvl)
XMA: 102217028(acadvl)
XCO: 114157390(acadvl)
PRET: 103480485(acadvl)
CVG: 107087781(acadvl)
NFU: 107372430(acadvl)
KMR: 108241814(acadvl)
ALIM: 106529201(acadvl)
AOCE: 111575585(acadvl)
CSEM: 103386901(acadvl)
POV: 109634887(acadvl)
LCF: 108897054(acadvl)
SDU: 111232992(acadvl)
SLAL: 111665745(acadvl)
HCQ: 109506947(acadvl)
BPEC: 110157677(acadvl)
MALB: 109966474(acadvl)
SASA: 106602820(acadvl)
OTW: 112216747
SALP: 111950426(acadvl)
ELS: 105010800(acadvl)
SFM: 108918781(acadvl) 108923151
PKI: 111860921(acadvl)
LCM: 102364546(ACADVL)
RTP: 109912656 109918899(acadvl)
BFO: 118427578
CIN: 100183990
SPU: 584710
APLC: 110981027
SKO: 100369524
DME: Dmel_CG7461(CG7461)
DER: 6547331
DSE: 6609917
DSI: Dsimw501_GD11444(Dsim_GD11444)
DAN: 6506293
DSR: 110177854
DPE: 6602657
DMN: 117188910
DAZ: 108614533
DNV: 108651701
DHE: 111592309
DVI: 6623490
MDE: 101891231
LCQ: 111683088
AME: 412025
BIM: 100747671
BTER: 100651720
CCAL: 108632159
OBB: 114874036
SOC: 105200554
MPHA: 105838446
AEC: 105149521
ACEP: 105622411
PBAR: 105429882
VEM: 105562928
HST: 105188087
DQU: 106746266
CFO: 105251587
LHU: 105667331
PGC: 109854598
OBO: 105276471
PCF: 106788263
NVI: 100116828
CSOL: 105368265
MDL: 103574466
TCA: 659957
DPA: 109541041
ATD: 109601372
BMOR: 101744941
BMAN: 114241040
PMAC: 106710891
PRAP: 110996061
HAW: 110380632
TNL: 113500974
API: 100162051
DNX: 107164135
RMD: 113560282
BTAB: 109036499
CLEC: 106668658
ZNE: 110832869
FCD: 110843829
TUT: 107362076
DPTE: 113799491
CSCU: 111630174
PTEP: 107450301
CEL: CELE_E04F6.5(acdh-12)
CBR: CBG13088
BMY: Bm1_24055
TSP: Tsp_10283
PCAN: 112555772
CRG: 105344745
MYI: 110463202
OBI: 106875659
LAK: 106158444
NVE: 5510970
EPA: 110251159
ADF: 107343075
AMIL: 114953943
PDAM: 113681975
SPIS: 111335626
DGT: 114521443
HMG: 100201063
AQU: 100638454
GAU: GAU_0440
 » show all
1  [PMID:1730632]
Izai K, Uchida Y, Orii T, Yamamoto S, Hashimoto T
Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase.
J Biol Chem 267:1027-33 (1992)
2  [PMID:7769092]
Aoyama T, Souri M, Ushikubo S, Kamijo T, Yamaguchi S, Kelley RI, Rhead WJ, Uetake K, Tanaka K, Hashimoto T
Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients.
J Clin Invest 95:2465-73 (1995)
3  [PMID:18227065]
McAndrew RP, Wang Y, Mohsen AW, He M, Vockley J, Kim JJ
Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase.
J Biol Chem 283:9435-43 (2008)
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