KEGG   ENZYME: 1.5.4.1
Entry
EC 1.5.4.1                  Enzyme                                 

Name
pyrimidodiazepine synthase;
PDA synthase;
pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening, cyclizing);
pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With a disulfide as acceptor
Sysname
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
Reaction(IUBMB)
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyltetrahydropterin + 2 glutathione [RN:R03984]
Reaction(KEGG)
R03984
Substrate
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one [CPD:C02587];
glutathione disulfide [CPD:C00127];
H2O [CPD:C00001]
Product
6-pyruvoyltetrahydropterin [CPD:C03684];
glutathione [CPD:C00051]
Comment
In the reverse direction, the reduction of 6-pyruvoyl-tetrahydropterin is accompanied by the opening of the 6-membered pyrazine ring and the formation of the 7-membered diazepine ring. The pyrimidodiazepine formed is an acetyldihydro derivative. Involved in the formation of the eye pigment drosopterin in Drosophila melanogaster.
History
EC 1.5.4.1 created 1990, modified 2014
Pathway
ec00480  Glutathione metabolism
ec00790  Folate biosynthesis
ec01100  Metabolic pathways
Orthology
K00310  pyrimidodiazepine synthase
Genes
BFO: 118417884 118418016 118418017
APLC: 110980055 110980113
SKO: 102801608 102805287 102805394
DME: Dmel_CG6673(GstO2) Dmel_CG6776(GstO3) Dmel_CG6781(se)
DER: 6545776 6545777 6545778
DSE: 6604889 6604890
DSI: Dsimw501_GD12980(Dsim_GD12980) Dsimw501_GD14099(Dsim_GD14099) Dsimw501_GD14100(Dsim_GD14100)
DYA: Dyak_GE20748 Dyak_GE20749 Dyak_GE21298
DAN: 6506964
DSR: 110189883 110189884 110190145
MDE: 101891696
AGA: AgaP_AGAP005749(GSTO1)
AAG: 23687505
AME: 552118
BIM: 100745560
BTER: 100646742
CCAL: 108628071
OBB: 114882731
SOC: 105200535
AEC: 105147922
ACEP: 105622284
PBAR: 105424214
VEM: 105563796
HST: 105185767
DQU: 106745381
CFO: 105256274
LHU: 105676415
PGC: 109858549
OBO: 105280891
PCF: 106789144
NVI: 100116224(GstO1)
CSOL: 105363631
MDL: 103577336
NVL: 108564623
BMOR: 100141441(GSTo4) 692819(GSTo1) 692941(GSTo2) 732973(GSTo3)
PMAC: 106708065
DNX: 107163884
AGS: 114121972
RMD: 113551979
BTAB: 109042194
CLEC: 106668275
TUT: 107364114
SHX: MS3_04642
 » show all
Reference
1  [PMID:6438092]
  Authors
Wiederrecht GJ, Brown GM.
  Title
Purification and properties of the enzymes from Drosophila melanogaster that catalyze the conversion of dihydroneopterin triphosphate to the pyrimidodiazepine precursor of the drosopterins.
  Journal
J Biol Chem 259:14121-7 (1984)
Reference
2  [PMID:16712527]
  Authors
Kim J, Suh H, Kim S, Kim K, Ahn C, Yim J
  Title
Identification and characteristics of the structural gene for the Drosophila eye  colour mutant sepia, encoding PDA synthase, a member of the omega class glutathione S-transferases.
  Journal
Biochem J 398:451-60 (2006)
DOI:10.1042/BJ20060424
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.4.1
IUBMB Enzyme Nomenclature: 1.5.4.1
ExPASy - ENZYME nomenclature database: 1.5.4.1
BRENDA, the Enzyme Database: 1.5.4.1
CAS: 93586-06-2
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