KEGG   ENZYME: 1.5.99.15
Entry
EC 1.5.99.15                Enzyme                                 

Name
dihydromethanopterin reductase (acceptor);
DmrX
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With unknown physiological acceptors
Sysname
5,6,7,8-tetrahydromethanopterin:acceptor 5,6-oxidoreductase
Reaction(IUBMB)
5,6,7,8-tetrahydromethanopterin + oxidized acceptor = 7,8-dihydromethanopterin + reduced acceptor [RN:R10802]
Reaction(KEGG)
R10802
Substrate
5,6,7,8-tetrahydromethanopterin [CPD:C01217];
oxidized acceptor
Product
7,8-dihydromethanopterin [CPD:C05927];
reduced acceptor [CPD:C00030]
Comment
This archaeal enzyme catalyses the last step in the biosynthesis of tetrahydromethanopterin, a coenzyme used in methanogenesis. The enzyme, characterized from the archaea Methanosarcina mazei and Methanocaldococcus jannaschii, is an iron-sulfur flavoprotein. cf. EC 1.5.1.47, dihydromethanopterin reductase [NAD(P)+].
History
EC 1.5.99.15 created 2014
Pathway
ec00790  Folate biosynthesis
Orthology
K18853  dihydromethanopterin reductase (acceptor)
Genes
MMT: Metme_1237
MDN: JT25_000420
MDH: AYM39_08130
MKO: MKLM6_1700
METL: U737_09955
MAH: MEALZ_1628
MBUR: EQU24_12275
MPSY: CEK71_07200
MEJ: Q7A_317
MEC: Q7C_1997
BPH: Bphy_5942
MPT: Mpe_A2615
LCH: Lcho_3144
RGE: RGE_40310
MFA: Mfla_1582
MMB: Mmol_0896
MEH: M301_0950
MEP: MPQ_1685
XAU: Xaut_4101
SNO: Snov_0764
MSC: BN69_1046
HDI: HDIA_2296
MJA: MJ_0208
MTH: MTH_1379
METC: MTCT_1253
MWO: MWSIV6_1760(dmrX)
METE: tca_01333
MST: Msp_1473
MRU: mru_0123(afpA)
MSI: Msm_1338
MEB: Abm4_1689(afpA)
MMIL: sm9_2248(afpA)
MEYE: TL18_00390
MOL: YLM1_1552
METH: MBMB1_1960
MFC: BRM9_2301(afpA3)
MCUB: MCBB_2245(dmrX)
MFV: Mfer_0803
MKA: MK1484
TSI: TSIB_0734
TLT: OCC_04872
THS: TES1_0923
PPAC: PAP_04215
MBAR: MSBR2_2801
MBAK: MSBR3_1897
MAC: MA_0696
MMA: MM_1854
MMAC: MSMAC_1600
METM: MSMTP_2728
MTHR: MSTHT_2252
MTHE: MSTHC_1028
MHOR: MSHOH_3527
MTP: Mthe_1166
MHI: Mhar_0340
MPD: MCP_1352
MEZ: Mtc_1049
RCI: RRC38
IHO: Igni_0932
IIS: EYM_03085
DKA: DKAM_0424
TAG: Tagg_0595
IAG: Igag_0279
 » show all
Reference
1  [PMID:23995635]
  Authors
Wang S, Tiongson J, Rasche ME
  Title
Discovery and characterization of the first archaeal dihydromethanopterin reductase, an iron-sulfur flavoprotein from Methanosarcina mazei.
  Journal
J Bacteriol 196:203-9 (2014)
DOI:10.1128/JB.00457-13
  Sequence
[mma:MM_1854]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.99.15
IUBMB Enzyme Nomenclature: 1.5.99.15
ExPASy - ENZYME nomenclature database: 1.5.99.15
BRENDA, the Enzyme Database: 1.5.99.15
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