KEGG   ENZYME: 1.5.99.5
Entry
EC 1.5.99.5                 Enzyme                                 

Name
methylglutamate dehydrogenase;
N-methylglutamate dehydrogenase;
N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With unknown physiological acceptors
Sysname
N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)
Reaction(IUBMB)
N-methyl-L-glutamate + acceptor + H2O = L-glutamate + formaldehyde + reduced acceptor [RN:R00609]
Reaction(KEGG)
R00609
Substrate
N-methyl-L-glutamate [CPD:C01046];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Product
L-glutamate [CPD:C00025];
formaldehyde [CPD:C00067];
reduced acceptor [CPD:C00030]
Comment
A number of N-methyl-substituted amino acids can act as donor; 2,6-dichloroindophenol is the best acceptor.
History
EC 1.5.99.5 created 1976
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K22084  methylglutamate dehydrogenase subunit A
K22085  methylglutamate dehydrogenase subunit B
K22086  methylglutamate dehydrogenase subunit C
K22087  methylglutamate dehydrogenase subunit D
Genes
NHL: Nhal_3490 Nhal_3491
NWR: E3U44_06770 E3U44_06775
SSAL: SPISAL_05340 SPISAL_05345 SPISAL_05350 SPISAL_05355 SPISAL_05360
GAI: IMCC3135_27100(soxB_2) IMCC3135_28025(soxB_3) IMCC3135_28030(soxD_3) IMCC3135_28035(soxA_4) IMCC3135_28040
LLP: GH975_07590 GH975_07595 GH975_07600
TSN: W908_05605 W908_05610 W908_05615 W908_05620
THIN: CRN91_04775 CRN91_04780 CRN91_04785 CRN91_04790
BPE: BP2515(soxG) BP2516(soxA) BP2517(soxD) BP2518(soxB)
BPC: BPTD_2472(soxG) BPTD_2473(soxA) BPTD_2474(soxD) BPTD_2475(soxB)
BPER: BN118_1508(soxB) BN118_1509(soxD) BN118_1510(soxA) BN118_1511(soxG)
BPET: B1917_1341(soxB) B1917_1342(soxD) B1917_1343(soxA) B1917_1344(soxG)
BPEU: Q425_21050(soxB) Q425_21060(soxD) Q425_21070(soxA) Q425_21080(soxG)
BPA: BPP3502(soxG) BPP3503(soxA) BPP3504(soxD) BPP3505(soxB)
BBH: BN112_4463(soxB) BN112_4464(soxD) BN112_4465(soxA) BN112_4466(soxG)
BBM: BN115_3626(soxG) BN115_3627(soxA) BN115_3628(soxD) BN115_3629(soxB)
BBX: BBS798_3730(soxG) BBS798_3731(soxA) BBS798_3732(soxD) BBS798_3733(soxB)
SME: SMc02606(soxA1) SMc02607(soxD) SMc02608(soxB)
SMX: SM11_chr3554(soxA1) SM11_chr3555(soxD1) SM11_chr3556(soxB1)
SMI: BN406_03217(soxA3) BN406_03218 BN406_03219(soxB3)
SMEL: SM2011_c02606(soxA1) SM2011_c02607(soxD) SM2011_c02608(soxB)
RHI: NGR_c14340(soxA2) NGR_c14350(soxD2) NGR_c14360(soxB2)
SFH: SFHH103_06340(soxB) SFHH103_06341(soxD) SFHH103_06342(soxA)
EAD: OV14_4045(soxA2) OV14_4047(soxB2)
ATU: Atu4222(soxA) Atu4223(soxD) Atu4224(soxB)
ARA: Arad_3493(soxAe) Arad_3494(soxDe) Arad_3496(soxBe) Arad_8357(soxDe) Arad_8358(soxBe)
ATF: Ach5_40390(soxA) Ach5_40400(soxD) Ach5_40410(soxB)
AVI: Avi_5744(soxA) Avi_5745(soxD) Avi_5746(soxB)
RET: RHE_PE00424(soxBe) RHE_PE00425(soxDe) RHE_PE00426(soxAe)
REL: REMIM1_PD00446(soxB-2) REMIM1_PD00447(soxD-2) REMIM1_PD00448(soxA-2)
REP: IE4803_PA00376(soxB-2) IE4803_PA00377(soxD-2) IE4803_PA00378(soxA-2)
REI: IE4771_PC00389(soxB-2) IE4771_PC00390(soxD-2) IE4771_PC00391(soxA-2)
RLE: pRL110560(soxB2) pRL110561(soxD2) pRL110562(soxA2)
RGA: RGR602_PC01866(soxB-2) RGR602_PC01867(soxD-2) RGR602_PC01868(soxA-2)
RHN: AMJ98_PD00431(soxB-2) AMJ98_PD00432(soxD-2) AMJ98_PD00433(soxA-2)
RPHA: AMC79_PB00345(soxB-2) AMC79_PB00346(soxD-2) AMC79_PB00347(soxA-2)
RHX: AMK02_PE00438(soxB-2) AMK02_PE00439(soxD-2) AMK02_PE00440(soxA-2)
RHK: Kim5_PB00407(soxB-2) Kim5_PB00408(soxD-2) Kim5_PB00409(soxA-2)
REZ: AMJ99_PC00432(soxB-2) AMJ99_PC00433(soxD-2) AMJ99_PC00434(soxA-2)
BRA: BRADO5878(soxB) BRADO5879(soxD) BRADO5880(soxA) BRADO5881(soxG)
BBT: BBta_1946(soxG) BBta_1947(soxA) BBta_1948(soxD) BBta_1949(soxB)
MEA: Mex_1p1545(soxG) Mex_1p1546 Mex_1p1547(soxD) Mex_1p1548(soxB)
MDI: METDI2319(soxG) METDI2320(soxA) METDI2321(soxD) METDI2322(soxB)
PLEO: OHA_1_03145(gcvT_3) OHA_1_03146 OHA_1_03147(soxB_1)
HDI: HDIA_3402(soxB_2) HDIA_3403 HDIA_3404(gcvT_3) HDIA_3405
RDE: RD1_0010(soxA) RD1_0011(soxD) RD1_0012(soxB) RD1_1788(soxB) RD1_1789(soxD) RD1_1790(soxA)
PAMN: pAMV1p0120(mgdA) pAMV1p0121(mgdB) pAMV1p0122(mgdC)
PSF: PSE_2334
PGL: PGA2_239p1680(soxA) PGA2_239p1690(soxD) PGA2_239p1700(soxB) PGA2_c08480(soxB1)
OAR: OA238_c05800(soxB1) OA238_c26540(soxB3) OA238_c26550(soxD2) OA238_c26560(soxA2)
OTM: OSB_22460(gcvT_2) OSB_22470 OSB_22490(soxB_2)
PTP: RCA23_c06810(soxB1) RCA23_c06820(soxD1) RCA23_c06830(soxA1) RCA23_c19580(soxB4) RCA23_c19590(soxD4) RCA23_c19600(soxA4) RCA23_c21700(soxB5)
AZL: AZL_a09550(soxB) AZL_a09560(soxD) AZL_a09570(soxA) AZL_a09580
PUB: SAR11_1284(soxB2) SAR11_1304
 » show all
Reference
1  [PMID:5028076]
  Authors
Hersh LB, Stark MJ, Worthen S, Fiero MK.
  Title
N-methylglutamate dehydrogenase: kinetic studies on the solubilized enzyme.
  Journal
Arch Biochem Biophys 150:219-26 (1972)
DOI:10.1016/0003-9861(72)90029-X
Other DBs
ExplorEnz - The Enzyme Database: 1.5.99.5
IUBMB Enzyme Nomenclature: 1.5.99.5
ExPASy - ENZYME nomenclature database: 1.5.99.5
BRENDA, the Enzyme Database: 1.5.99.5
CAS: 37217-26-8
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