| Entry |
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| Name |
nitrite reductase [NAD(P)H];
nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate));
assimilatory nitrite reductase (ambiguous);
nitrite reductase [NAD(P)H2];
NAD(P)H2:nitrite oxidoreductase;
nit-6 (gene name)
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| Class |
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
ammonia:NAD(P)+ oxidoreductase
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| Reaction(IUBMB) |
NH3 + 3 NAD(P)+ + 2 H2O = nitrite + 3 NAD(P)H + 5 H+ [RN: R00787 R00789]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
An iron-sulfur flavoprotein (FAD) containing siroheme. The enzymes from the fungi Neurospora crassa [1], Emericella nidulans [2] and Candida nitratophila [4] and the bacterium Aliivibrio fischeri [3] can use either NADPH or NADH as electron donor. cf. EC 1.7.1.15, nitrite reductase (NADH).
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| History |
EC 1.7.1.4 created 1961 as EC 1.6.6.4, transferred 2002 to EC 1.7.1.4, modified 2013
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| Pathway |
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| Orthology |
| K17877 | nitrite reductase (NAD(P)H) |
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| Genes |
» show all
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| Reference |
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| Authors |
NICHOLAS DJ, MEDINA A, JONES OT |
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| Title |
A nitrite reductase from Neurospora crassa. |
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| Journal |
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| Reference |
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| Authors |
Pateman JA, Rever BM, Cove DJ |
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| Title |
Genetic and biochemical studies of nitrate reduction in Aspergillus nidulans. |
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| Journal |
Biochem J 104:103-11 (1967) |
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| Reference |
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| Authors |
Prakash OM, Sadana JC |
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| Title |
Purification, characterization and properties of nitrite reductase of Achromobacter fischeri. |
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| Journal |
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| Reference |
4 |
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| Authors |
Rivas, J., Guerrero, M. G., Paneque, A. and Losada, M. |
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| Title |
Characterization of the nitrate-reducing system of the yeast Torulopsis nitratophila. |
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| Journal |
Plant Sci Lett 1:105-113 (1973) |
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| Reference |
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| Authors |
Lafferty MA, Garrett RH |
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| Title |
Purification and properties of the Neurospora crassa assimilatory nitrite reductase. |
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| Journal |
J Biol Chem 249:7555-67 (1974) |
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| Reference |
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| Authors |
Vega JM, Garrett RH |
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| Title |
Siroheme: a prosthetic group of the Neurospora crassa assimilatory nitrite reductase. |
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| Journal |
J Biol Chem 250:7980-9 (1975) |
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| Reference |
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| Authors |
Greenbaum P, Prodouz KN, Garrett RH |
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| Title |
Preparation and some properties of homogeneous Neurospora crassa assimilatory NADPH-nitrite reductase. |
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| Journal |
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| Reference |
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| Authors |
Prodouz KN, Garrett RH |
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| Title |
Neurospora crassa NAD(P)H-nitrite reductase. Studies on its composition and structure. |
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| Journal |
J Biol Chem 256:9711-7 (1981) |
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| Reference |
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| Authors |
Exley GE, Colandene JD, Garrett RH |
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| Title |
Molecular cloning, characterization, and nucleotide sequence of nit-6, the structural gene for nitrite reductase in Neurospora crassa. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Colandene JD, Garrett RH. |
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| Title |
Functional dissection and site-directed mutagenesis of the structural gene for NAD(P)H-nitrite reductase in Neurospora crassa. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.7.1.4 |
| ExPASy - ENZYME nomenclature database: | 1.7.1.4 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 1.7.1.4 |
| BRENDA, the Enzyme Database: | 1.7.1.4 |
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| LinkDB |
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