KEGG   ENZYME: 1.7.2.7Help
Entry
EC 1.7.2.7                  Enzyme                                 

Name
hydrazine synthase;
HZS
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor
BRITE hierarchy
Sysname
hydrazine:ferricytochrome-c oxidoreductase
Reaction(IUBMB)
hydrazine + H2O + 3 ferricytochrome c = nitric oxide + ammonium + 3 ferrocytochrome c [RN:R09799]
Reaction(KEGG)
Substrate
hydrazine [CPD:C05361];
H2O [CPD:C00001];
ferricytochrome c [CPD:C00125]
Product
nitric oxide [CPD:C00533];
ammonium;
ferrocytochrome c [CPD:C00126]
Comment
The enzyme, characterized from anaerobic ammonia oxidizers (anammox bacteria), is one of only two enzymes that are known to form an N-N bond (the other being EC 1.7.1.14, nitric oxide reductase [NAD(P)+, nitrous oxide-forming]). The enzyme from the bacterium Candidatus Kuenenia stuttgartiensis is heterotrimeric and contains multiple c-type cytochromes.
History
EC 1.7.2.7 created 2016
Pathway
ec00910  Nitrogen metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K20932  hydrazine synthase subunit
K20933  hydrazine synthase subunit
K20934  hydrazine synthase subunit
Genes
KST: KSMBR1_2703(hzsC_3) KSMBR1_2704(hzsB_3) KSMBR1_2713(hzsA_1)
Taxonomy
Reference
1  [PMID:21964329]
  Authors
Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den Camp HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M.
  Title
Molecular mechanism of anaerobic ammonium oxidation.
  Journal
Nature 479:127-30 (2011)
DOI:10.1038/nature10453
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.7.2.7
IUBMB Enzyme Nomenclature: 1.7.2.7
ExPASy - ENZYME nomenclature database: 1.7.2.7
BRENDA, the Enzyme Database: 1.7.2.7
LinkDB All DBs

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