| Entry |
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| Name |
nitrate reductase (quinone);
nitrate reductase A;
nitrate reductase Z;
quinol/nitrate oxidoreductase;
quinol-nitrate oxidoreductase;
quinol:nitrate oxidoreductase;
NarA;
NarZ;
NarGHI;
dissimilatory nitrate reductase
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| Class |
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a quinone or similar compound as acceptor
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| Sysname |
nitrite:quinone oxidoreductase
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| Reaction(IUBMB) |
nitrate + a quinol = nitrite + a quinone + H2O [RN: R09497]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A membrane-bound enzyme which supports anaerobic respiration on nitrate under anaerobic conditions and in the presence of nitrate. Contains the bicyclic form of the molybdo-bis(molybdopterin guanine dinucleotide) cofactor, iron-sulfur clusters and heme b. Escherichia coli expresses two forms NarA and NarZ, both being comprised of three subunits.
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| History |
EC 1.7.5.1 created 2010
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K00370 | nitrate reductase / nitrite oxidoreductase, alpha subunit |
| K00371 | nitrate reductase / nitrite oxidoreductase, beta subunit |
| K00374 | nitrate reductase gamma subunit |
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| Genes |
» show all
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| Reference |
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| Authors |
Enoch HG, Lester RL |
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| Title |
The role of a novel cytochrome b-containing nitrate reductase and quinone in the in vitro reconstruction of formate-nitrate reductase activity of E. coli. |
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| Journal |
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| Reference |
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| Authors |
Bertero MG, Rothery RA, Palak M, Hou C, Lim D, Blasco F, Weiner JH, Strynadka NC |
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| Title |
Insights into the respiratory electron transfer pathway from the structure of nitrate reductase A. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Lanciano P, Magalon A, Bertrand P, Guigliarelli B, Grimaldi S |
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| Title |
High-stability semiquinone intermediate in nitrate reductase A (NarGHI) from Escherichia coli is located in a quinol oxidation site close to heme bD. |
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| Journal |
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| Reference |
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| Authors |
Bertero MG, Rothery RA, Boroumand N, Palak M, Blasco F, Ginet N, Weiner JH, Strynadka NC |
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| Title |
Structural and biochemical characterization of a quinol binding site of Escherichia coli nitrate reductase A. |
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| Journal |
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| Reference |
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| Authors |
Bonnefoy V, Demoss JA |
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| Title |
Nitrate reductases in Escherichia coli. |
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| Journal |
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| Reference |
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| Authors |
Guigliarelli B, Asso M, More C, Augier V, Blasco F, Pommier J, Giordano G, Bertrand P |
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| Title |
EPR and redox characterization of iron-sulfur centers in nitrate reductases A and Z from Escherichia coli. Evidence for a high-potential and a low-potential class and their relevance in the electron-transfer mechanism. |
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| Journal |
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| Reference |
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| Authors |
Iobbi-Nivol C, Santini CL, Blasco F, Giordano G |
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| Title |
Purification and further characterization of the second nitrate reductase of Escherichia coli K12. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.7.5.1 |
| ExPASy - ENZYME nomenclature database: | 1.7.5.1 |
| BRENDA, the Enzyme Database: | 1.7.5.1 |
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| LinkDB |
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