KEGG   ENZYME: 1.8.1.18Help
Entry
EC 1.8.1.18                 Enzyme                                 

Name
NAD(P)H sulfur oxidoreductase (CoA-dependent);
NADPH NSR;
S0 reductase;
coenzyme A-dependent NADPH sulfur oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
hydrogen sulfide:NAD(P)+ oxidoreductase (CoA-dependent)
Reaction(IUBMB)
hydrogen sulfide + NAD(P)+ = sulfur + NAD(P)H + H+ [RN:R10419 R10438]
Reaction(KEGG)
Substrate
hydrogen sulfide [CPD:C00283];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
sulfur [CPD:C00087];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This FAD-dependent enzyme, characterized from the archaeon Pyrococcus furiosus, is responsible for NAD(P)H-linked sulfur reduction. The activity with NADH is about half of that with NADPH. The reaction is dependent on CoA, although the nature of this dependency is not well understood.
History
EC 1.8.1.18 created 2013
Orthology
K18367  CoA-dependent NAD(P)H sulfur oxidoreductase
Genes
AFU: AF_0254 AF_0395
AFG: AFULGI_00002410
AVE: Arcve_0623
AST: Asulf_00763 Asulf_00806
FPL: Ferp_1513
GAC: GACE_0171 GACE_1887
GAH: GAH_00177 GAH_00543
TAC: Ta0837
TVO: TVG0846070(TVG0846070)
PTO: PTO1479
FAI: FAD_1225
CDIV: CPM_1150
PHO: PH0572(PH0572)
PAB: PAB0936(noxA-1)
PFU: PF1186
PFI: PFC_05150
PYN: PNA2_1248
PYS: Py04_1126
TKO: TK1299
TON: TON_0305
TGA: TGAM_1050
TSI: TSIB_0263
THE: GQS_04305
THA: TAM4_984
THM: CL1_0500
TLT: OCC_09741
THS: TES1_0076
TNU: BD01_0098
TEU: TEU_06045
THH: CDI07_01600(cdr)
PPAC: PAP_01275
IHO: Igni_0671
IIS: EYM_06280
IAG: Igag_0286
HBU: Hbut_0802
STO: STK_22470(nox)
SSO: SSO2283
SOL: Ssol_0100
SSOA: SULA_0096(cdr)
SSOL: SULB_0097(cdr)
SSOF: SULC_0096(cdr)
SAI: Saci_0149(npx)
SID: M164_0094
SII: LD85_0095
SIH: SiH_0095
SIR: SiRe_0093
SIC: SiL_0093
MSE: Msed_2080
MCN: Mcup_0209
AHO: Ahos_0488
PAI: PAE2371
PIS: Pisl_0611
PCL: Pcal_1700
PAS: Pars_1572
TNE: Tneu_1510
TUZ: TUZN_2129
TTN: TTX_1268 TTX_1302(nox) TTX_1303(nox) TTX_1426(noxA)
TPE: Tpen_0143
 » show all
Taxonomy
Reference
1  [PMID:17449625]
  Authors
Schut GJ, Bridger SL, Adams MW
  Title
Insights into the metabolism of elemental sulfur by the hyperthermophilic archaeon Pyrococcus furiosus: characterization of a coenzyme A- dependent NAD(P)H sulfur oxidoreductase.
  Journal
J Bacteriol 189:4431-41 (2007)
DOI:10.1128/JB.00031-07
  Sequence
[pfu:PF1186]
Reference
2  [PMID:21965560]
  Authors
Bridger SL, Clarkson SM, Stirrett K, DeBarry MB, Lipscomb GL, Schut GJ, Westpheling J, Scott RA, Adams MW
  Title
Deletion strains reveal metabolic roles for key elemental sulfur-responsive proteins in Pyrococcus furiosus.
  Journal
J Bacteriol 193:6498-504 (2011)
DOI:10.1128/JB.05445-11
Reference
3  [PMID:15720393]
  Authors
Harris DR, Ward DE, Feasel JM, Lancaster KM, Murphy RD, Mallet TC, Crane EJ 3rd.
  Title
Discovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii. Implications for this disulfide metabolism of anaerobic hyperthermophiles.
  Journal
FEBS J 272:1189-200 (2005)
DOI:10.1111/j.1742-4658.2005.04555.x
  Sequence
[pho:PH0572]
Other DBs
ExplorEnz - The Enzyme Database: 1.8.1.18
IUBMB Enzyme Nomenclature: 1.8.1.18
ExPASy - ENZYME nomenclature database: 1.8.1.18
BRENDA, the Enzyme Database: 1.8.1.18
LinkDB All DBs

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