KEGG   ENZYME: 1.8.1.19
Entry
EC 1.8.1.19                 Enzyme                                 

Name
sulfide dehydrogenase;
SuDH
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
Sysname
hydrogen sulfide,polysulfide:NADP+ oxidoreductase
Reaction(IUBMB)
hydrogen sulfide + (sulfide)n + NADP+ = (sulfide)n+1 + NADPH + H+ [RN:R10512]
Reaction(KEGG)
R10512
Substrate
hydrogen sulfide [CPD:C00283];
(sulfide)n [CPD:C19692];
NADP+ [CPD:C00006]
Product
(sulfide)n+1;
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
A iron-sulfur flavoprotein. In the archaeon Pyrococcus furiosus the enzyme is involved in the oxidation of NADPH which is produced in peptide degradation. The enzyme also catalyses the reduction of sulfur with lower activity.
History
EC 1.8.1.19 created 2013
Orthology
K20202  sulfide dehydrogenase subunit alpha
K20203  sulfide dehydrogenase subunit beta
Genes
PCAG: NCTC12856_00737(pyrK_2)
ASAC: ATHSA_1628
PFU: PF1327 PF1328
PFI: PFC_05850 PFC_05855
PAB: PAB1737 PAB1738
PYN: PNA2_1556 PNA2_1557
PYA: PYCH_00010 PYCH_08330
PYS: Py04_1133 Py04_1134
PYC: TQ32_03135
TON: TON_0056 TON_0057
 » show all
Reference
1  [PMID:7961401]
  Authors
Ma K, Adams MW
  Title
Sulfide dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus: a  new multifunctional enzyme involved in the reduction of elemental sulfur.
  Journal
J Bacteriol 176:6509-17 (1994)
DOI:10.1128/JB.176.21.6509-6517.1994
  Sequence
Reference
2  [PMID:10968624]
  Authors
Hagen WR, Silva PJ, Amorim MA, Hagedoorn PL, Wassink H, Haaker H, Robb FT
  Title
Novel structure and redox chemistry of the prosthetic groups of the iron-sulfur flavoprotein sulfide dehydrogenase from Pyrococcus furiosus; evidence for a [2Fe-2S] cluster with Asp(Cys)3 ligands.
  Journal
J Biol Inorg Chem 5:527-34 (2000)
DOI:10.1007/PL00021452
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.8.1.19
IUBMB Enzyme Nomenclature: 1.8.1.19
ExPASy - ENZYME nomenclature database: 1.8.1.19
BRENDA, the Enzyme Database: 1.8.1.19
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