KEGG   ENZYME: 1.8.3.5
Entry
EC 1.8.3.5                  Enzyme                                 
Name
prenylcysteine oxidase;
prenylcysteine lyase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With oxygen as acceptor
Sysname
S-prenyl-L-cysteine:oxygen oxidoreductase
Reaction(IUBMB)
an S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2 [RN:R07360]
Reaction(KEGG)
R07360 > R09562
Substrate
S-prenyl-L-cysteine [CPD:C06751];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
prenal [CPD:C07330];
L-cysteine [CPD:C00097];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD). Cleaves the thioether bond of S-prenyl-L-cysteines, such as S-farnesylcysteine and S-geranylgeranylcysteine. N-Acetyl-prenylcysteine and prenylcysteinyl peptides are not substrates. May represent the final step in the degradation of prenylated proteins in mammalian tissues. Originally thought to be a simple lyase so it had been classified as EC 4.4.1.18.
History
EC 1.8.3.5 created 2000 as EC 4.4.1.18, transferred 2002 to EC 1.8.3.5
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K05906  prenylcysteine oxidase / farnesylcysteine lyase
Genes
HSA51449(PCYOX1)
PTR470398(PCYOX1)
PPS100971101(PCYOX1)
GGO101138892(PCYOX1)
PON100457284(PCYOX1)
NLE100606095(PCYOX1)
MCC710068(PCYOX1)
MCF101926201(PCYOX1)
CSAB103220094(PCYOX1)
CATY105576534(PCYOX1)
PANU101022266(PCYOX1)
TGE112605329(PCYOX1)
RRO104659273 104661318(PCYOX1)
RBB108516355(PCYOX1)
TFN117061975(PCYOX1)
PTEH111550486(PCYOX1)
CJC100404939(PCYOX1)
SBQ101047105(PCYOX1)
CSYR103264662(PCYOX1)
MMUR105863272 105863282(PCYOX1)
OGA100954104(PCYOX1)
MMU66881(Pcyox1)
MCAL110295686(Pcyox1)
MPAH110316366(Pcyox1)
RNO246302(Pcyox1)
MCOC116099179(Pcyox1)
MUN110547181(Pcyox1)
CGE100774789(Pcyox1)
PLEU114680827(Pcyox1)
NGI103725906(Pcyox1)
HGL101725032(Pcyox1)
CPOC100725382(Pcyox1)
CCAN109698768(Pcyox1)
DORD105990225(Pcyox1)
DSP122110515(Pcyox1)
OCU100354763(PCYOX1)
OPI101532356(PCYOX1)
TUP102492977(PCYOX1)
CFA481418(PCYOX1)
VVP112934410(PCYOX1)
VLG121490816(PCYOX1)
AML100468481(PCYOX1)
UMR103671811(PCYOX1)
UAH113244236(PCYOX1)
UAR123786032(PCYOX1)
ELK111148173
LLV125108533
MPUF101676752(PCYOX1)
ORO101383182(PCYOX1)
EJU114218922(PCYOX1)
ZCA113937570(PCYOX1)
MLX118007999(PCYOX1)
FCA101096467(PCYOX1)
PYU121019288(PCYOX1)
PBG122496968(PCYOX1)
PTG102955992(PCYOX1)
PPAD109262459(PCYOX1)
AJU106967763(PCYOX1)
HHV120236635(PCYOX1)
BTA100125835(PCYOX1)
BOM102279554(PCYOX1)
BIU109566249(PCYOX1)
BBUB102399126(PCYOX1)
CHX102176973(PCYOX1)
OAS101105397(PCYOX1)
ODA120851393(PCYOX1)
CCAD122441876(PCYOX1)
SSC100624596(PCYOX1)
CFR102511924(PCYOX1)
CBAI105075789(PCYOX1)
CDK105088901(PCYOX1)
VPC102546040(PCYOX1)
BACU103010853(PCYOX1)
LVE103091374(PCYOX1)
OOR101280418(PCYOX1)
DLE111167878(PCYOX1)
PCAD102993678(PCYOX1)
PSIU116764285(PCYOX1)
ECB100060594(PCYOX1) 100060629(PCYOX1L)
EPZ103547599(PCYOX1)
EAI106828313(PCYOX1)
MYB102262695(PCYOX1)
MYD102755614(PCYOX1)
MMYO118668888(PCYOX1)
MLF102436365(PCYOX1)
MNA107529289(PCYOX1)
PKL118717482(PCYOX1)
HAI109385413(PCYOX1)
DRO112303075(PCYOX1)
SHON118988494(PCYOX1)
AJM119035785(PCYOX1)
PDIC114499268(PCYOX1)
PHAS123811846(PCYOX1)
MMF118630835(PCYOX1)
RFQ117033026(PCYOX1)
PALE102888402(PCYOX1)
PGIG120594429(PCYOX1)
PVP105295760(PCYOX1)
RAY107519108(PCYOX1)
MJV108402540
TOD119259044(PCYOX1)
SARA101543825(PCYOX1)
LAV100674445(PCYOX1)
TMU101360021
DNM101416984(PCYOX1)
MDO100032803(PCYOX1)
GAS123236997(PCYOX1)
SHR100929029(PCYOX1)
PCW110207621(PCYOX1)
OAA100088724(PCYOX1L) 100091365(PCYOX1)
GGA426297(PCYOX1)
PCOC116231312(PCYOX1)
MGP100545768(PCYOX1)
CJO107323602(PCYOX1)
NMEL110387147(PCYOX1)
APLA101804304(PCYOX1L)
ACYG106046247(PCYOX1)
AFUL116499319(PCYOX1)
TGU100226181(PCYOX1L) 115498183(PCYOX1)
LSR110478629(PCYOX1)
SCAN103824661(PCYOX1) 103824662
PMOA120499138(PCYOX1)
OTC121336006(PCYOX1)
PRUF121352744(PCYOX1)
GFR102032195(PCYOX1)
FAB101808104(PCYOX1)
PHI102109379(PCYOX1)
PMAJ107213988(PCYOX1)
CCAE111938747(PCYOX1)
CCW104694867(PCYOX1)
ETL114066448(PCYOX1)
FPG101917041(PCYOX1)
FCH102057230(PCYOX1)
CLV102097250(PCYOX1)
EGZ104123772(PCYOX1)
NNI104019025(PCYOX1L)
ACUN113488068(PCYOX1)
PADL103914322(PCYOX1)
ACHC115349954(PCYOX1)
AAM106490249(PCYOX1)
AROW112973628(PCYOX1)
NPD112949768(PCYOX1)
DNE112996703(PCYOX1)
ASN102379956(PCYOX1)
AMJ102574611(PCYOX1)
CPOO109317286(PCYOX1)
PSS102452243(PCYOX1)
CMY102947169(PCYOX1)
CPIC101941069(PCYOX1)
TST117872906(PCYOX1)
CABI116833381
MRV120399585(PCYOX1)
ACS100563966(pcyox1)
PVT110072210(PCYOX1) 110075841
SUND121932951(PCYOX1)
PBI103055758(PCYOX1)
PMUR107283235(PCYOX1)
TSR106542621(PCYOX1)
PGUT117673340(PCYOX1)
VKO123016770(PCYOX1)
PMUA114602675(PCYOX1)
ZVI118086407(PCYOX1)
GJA107118770 107118771
XLA108711539(pcyox1.L)
XTR549056(pcyox1)
NPR108785358(PCYOX1)
RTEM120932969 120932970(PCYOX1)
BBUF120986091(PCYOX1)
BGAR122927443(PCYOX1) 122927444
DRE550289(pcyox1)
SRX107713365 107744114
SANH107686458 107688072
SGH107562568 107569400 107581983
CCAR109045315 109052061 109092885
CAUA113038184(pcyox1l) 113054126 113075381 113110395
IPU100304900 108276731(pcyox1)
PHYP113543127(pcyox1l) 113544142
SMEO124393874(pcyox1)
AMEX103021813(pcyox1l) 103023969 103044269
EEE113575162 113585763(pcyox1l)
TRU101065828(pcyox1l) 101067237(pcyox1)
TNGGSTEN00003251G001 GSTEN00017330G001
LCO104923352(pcyox1)
NCC104950632(pcyox1l) 104961020(pcyox1)
CGOB115017104 115019279(pcyox1l)
ELY117262769 117269681(pcyox1)
PLEP121952973 121959547(pcyox1)
SLUC116035072(pcyox1) 116037040
ECRA117955713 117959305(pcyox1)
PFLV114566340(pcyox1l) 114570624(pcyox1)
GAT120821779 120832249(pcyox1)
PPUG119215256 119226526(pcyox1)
MSAM119894904 119918692(pcyox1)
CUD121518342 121525634(pcyox1)
MZE101483866(pcyox1l) 101485660
ONL100689931(pcyox1l) 100704244(pcyox1)
OAU116319707 116322403(pcyox1)
OLA101155871(pcyox1l) 101172915(pcyox1)
OML112142954 112163513(pcyox1)
XMA102229017(pcyox1) 102235232(pcyox1l)
XCO114149713(pcyox1) 114153555(pcyox1l)
XHE116724427(pcyox1) 116728776(pcyox1l)
PRET103473683(pcyox1)
PFOR103139082(pcyox1l) 103148439(pcyox1)
PLAI106955705(pcyox1l) 106958396(pcyox1)
PMEI106907593(pcyox1l) 106927958(pcyox1)
GAF122844561 122846896(pcyox1)
CVG107084167(pcyox1l) 107092669(pcyox1)
CTUL119771586(pcyox1) 119792693
GMU124872403(pcyox1) 124876542
NFU107372848(pcyox1) 107386753(pcyox1l)
KMR108232575(pcyox1) 108238884
ALIM106514514(pcyox1) 106524041(pcyox1l)
NWH119420742 119424694(pcyox1)
AOCE111568369(pcyox1) 111584671(pcyox1l)
CSEM103390492(pcyox1) 103395449(pcyox1l)
POV109626079(pcyox1) 109643089(pcyox1l)
SSEN122779949 122781775(pcyox1)
HHIP117772032(pcyox1) 117774242
LCF108879214(pcyox1) 108893957(pcyox1l)
SDU111217056(pcyox1l) 111234251(pcyox1)
SLAL111647482(pcyox1l) 111668094(pcyox1)
XGL120802841 120806268(pcyox1)
HCQ109513148(pcyox1)
BPEC110155903(pcyox1l) 110160541(pcyox1)
MALB109960018(pcyox1l) 109963438(pcyox1)
SASA106564891
OTW112219406(pcyox1)
OMY110523690(pcyox1) 110537783
OGO124048853
ONE115124212(pcyox1)
SALP111961511(pcyox1) 111981600(pcyox1l)
SNH120026318
ELS105014988
SFM108934092(pcyox1l) 108935642(pcyox1)
PKI111836976(pcyox1l) 111849890(pcyox1)
AANG118212864(pcyox1)
LOC102682350(pcyox1)
PSPA121302340 121303146 121324023
ARUT117397725 117962552
LCM102366651(PCYOX1)
CMK103188150 103190257(pcyox1)
RTP109915331(pcyox1l)
BFO118414937 118419608
CIN100186242
SCLV120330559 120340686
SPU115918874 577359 582165 592408
APLC110989094
SKO100370797 102805603
AME412611
ACER107998886
ALAB122720980
BIM100743723
BBIF117211066
BVK117232243
BVAN117157814
BTER100649389
BPYO122573885
CCAL108626446
OBB114875502
MGEN117223232
NMEA116424831
CGIG122396007
SOC105193102 105198266 105206662
MPHA105831429
AEC105146005
ACEP105623574
PBAR105431014
VEM105560811
HST105192368
DQU106746985
CFO105249342
FEX115244363
LHU105678694
PGC109852538
OBO105280562
PCF106788841
PFUC122525219
VPS122627819
CSOL105364959
TPRE106651310
MDL103580178
CGLO123260709
FAS105265393
DAM107036125
AGIF122851958
CCIN107263592
API100160471
DNX107163506
AGS114127115
RMD113559222
BTAB109031110
DCI103506991
CLEC106672112
NLU111049375 120354361
PHUPhum_PHUM389870
ZNE110832717
FCD110846125
DPXDAPPUDRAFT_269767 DAPPUDRAFT_304769 DAPPUDRAFT_95738
PVM113802630
PJA122253278
PCLA123756431
HAZT108678704
EAF111701761
DPTE113792744
CSCU111615199
PTEP107451756
SDM118205609
LOALOAG_06248
TSPTsp_01052
LGILOTGIDRAFT_236715
PCAN112560113
BGT106056814
GAE121381029
CRG105323619
MYI110462099
PMAX117335498
OBI106883316
OSN115224350
LAK106171255
SMMSmp_125500
SHXMS3_0017856
OVIT265_00458
EGLEGR_06057
NVE5512734
EPA110254130
ATEN116302930
ADF107343001
AMIL114976187
PDAM113684316
SPIS111340782
DGT114523253
XEN124452467
HMG100200423
AQU100641107
ATHAT5G63910(FCLY)
ALY9302655
CRB17875809
CSAT104727020 104741908 104762535
EUSEUTSA_v10004131mg
BRP103873809
BNA106347946 106348069
BOE106336305
RSZ108856168
THJ104818420 104819345
CPAP110816574
CIT102619140
CICCICLE_v10000962mg
PVY116118145
MINC123199441
TCC18611918
GRA105763575
GHI107925476 107945423
GAB108483661
DZI111292606 111300977
EGR104418080 104418081
GMX100819877
GSJ114415804
PVUPHAVU_009G154600g
VRA106779708
VAR108330593
VUN114164811
CCAJ109814849
APRC113849182
MTRMTR_3g096675
CAM101495143
LJALj1g3v1355770.1(Lj1g3v1355770.1)
ADU107463306
AIP107613822
AHF112707944 112771151
LANG109339143
FVE101303553
RCN112188298
PPER18780160
PMUM103327053
PAVI110754263
PDUL117626550
MDM103400276
PXB103946782
ZJU107425615
MNT21393162
CSV101215055
CMO103486051
BHJ120073321
MCHA111025661
CMAX111467195
CMOS111435563
CPEP111804493
RCU8270275
JCU105641920
HBR110666793
MESC110628401
POP18100924 7466760
PEU105119050 105119051 105124535
PALZ118043479 118043487
JRE108996352
QSU112013734 112028612 112029314 112029316
QLO115965681
TWL119991679
VVI100268071
VRI117918625
SLY101250000
SPEN107006015
SOT102583614
CANN107850614
NTA107795977 107826766
NSY104243491
NTO104115921 104118441
NAU109237424
INI109172521
ITR116019000
SIND105178024
OEU111401093
EGT105976860
SSPL121769750
ECAD122581291
LSV111899421
CCAV112519116
DCR108226355
CSIN114256721 114256754 114285854
BVG104890578
SOE110779740 110798959
CQI110701286 110736618
NNU104605839 104606672
MING122056992
TSS122660313 122670028
PSOM113356270
NCOL116266860
OBR102720704
BDI100821994
ATS109768343
TDC119357246 119366537
TAES123047537 123055345 123161600 123191158
SBI8064304
ZMA103642227
SITA101780490
SVS117848456
PVIR120642230 120683689
PHAI112899569
PDA103702607
EGU105037230
MUS103971814
DCT110098590
PEQ110021299
AOF109826352
ATR18432903
SMOSELMODRAFT_170018 SELMODRAFT_443023
PPP112279627
CSLCOCSUDRAFT_47763
CVRCHLNCDRAFT_142455
APROF751_1899
CCPCHC_T00001248001
SLBAWJ20_3123
NCRNCU09710
NTENEUTE1DRAFT131085(NEUTE1DRAFT_131085)
SMPSMAC_06050
PANPODANSg1272
TTTTHITE_2145487
MTMMYCTH_2308190
MGRMGG_03858
TMNUCRPA7_7168
SSCKSPSK_04174
FGRFGSG_06053
FPUFPSE_04205
FVRFVEG_04685
FOXFOXG_07758
NHENECHADRAFT_78887
TRETRIREDRAFT_47814
TRRM419DRAFT_55662
MAWMAC_01917
MAJMAA_04674
PLJVFPFJ_02124
VALVDBG_03079
VDAVDAG_03987
CFJCFIO01_06455
SAPOSAPIO_CDS4414
ELAUCREL1_4173
PFYPFICI_03485
SSLSS1G_07921 SS1G_13940
BFUBCIN_15g00860 BCIN_15g04470
MBEMBM_07457
PSCOLY89DRAFT_686416 LY89DRAFT_786734
GLZGLAREA_07174 GLAREA_12356
ANIAN3057.2
AFMAFUA_3G09330
ACTACLA_037250
NFINFIA_067810
ANGANI_1_1612144(An16g02960)
AFVAFLA_004128
ALUCAKAW2_70257S
ACHEACHE_20881S
APUUAPUU_12387S APUU_30472A
PCSPc12g16150
PDPPDIP_75960
TMFPMAA_045370
CIMCIMG_01871
CPWCPC735_046370
UREUREG_06824
PBLPAAG_07424
PBNPADG_05122
ABEARB_01153
TVETRV_03271
AJEHCAG_05398
BGHBDBG_00461
PNOSNOG_11973
PTEPTT_12890
BZECOCCADRAFT_80711
BSCCOCSADRAFT_157070
BORCOCMIDRAFT_83964
AALTCC77DRAFT_1028353
ZTRMYCGRDRAFT_23211
PFJMYCFIDRAFT_87304
BCOMBAUCODRAFT_371035
TMLGSTUM_00006317001 GSTUM_00011429001
CNECNK01940
CNBCNBK1600
CGICGB_K2060C
TMSTREMEDRAFT_73026
TASAA1Q1_03762
TVSTRAVEDRAFT_172083
DSQDICSQDRAFT_155080
PCOPHACADRAFT_259228
SHSSTEHIDRAFT_89550
HIRHETIRDRAFT_308119
PSQPUNSTDRAFT_94528 PUNSTDRAFT_94532
ADLAURDEDRAFT_109626
FMEFOMMEDRAFT_146234
GTRGLOTRDRAFT_69176
LBCLACBIDRAFT_300931
MRRMoror_288
CCICC1G_01677
SCMSCHCODRAFT_46910
ABPAGABI1DRAFT117116(AGABI1DRAFT_117116)
ABVAGABI2DRAFT214837(AGABI2DRAFT_214837)
CPUTCONPUDRAFT_68904
SLASERLADRAFT_445942
WSEWALSEDRAFT_33355
WICJ056_001304
UMAUMAG_04318
PFPPFL1_04520
MRTMRET_1718
PGRPGTG_03244
MLRMELLADRAFT_79816
MBRMONBRDRAFT_26319
SREPTSG_07160 PTSG_10804
DDIDDB_G0287201
DPPDICPUDRAFT_94966
DFADFA_01059
ACANACA1_031620 ACA1_108260
TGOTGME49_236010
TETTTHERM_00158490
PTMGSPATT00000286001 PTMB.231c
SMINv1.2.010012.t1(symbB.v1.2.010012.t1) v1.2.035027.t1(symbB.v1.2.035027.t1)
PTIPHATRDRAFT_47005
TPSTHAPSDRAFT_5586
SPARSPRG_14908
EHXEMIHUDRAFT_109080
GTTGUITHDRAFT_162871
NGRNAEGRDRAFT_62621
HSUHLASF_1152
HSFHLASA_1140
 » show all
Reference
1  [PMID:9287348]
  Authors
Zhang L, Tschantz WR, Casey PJ.
  Title
Isolation and characterization of a prenylcysteine lyase from bovine brain.
  Journal
J Biol Chem 272:23354-9 (1997)
DOI:10.1074/jbc.272.37.23354
Reference
2  [PMID:11078725]
  Authors
Tschantz WR, Digits JA, Pyun HJ, Coates RM, Casey PJ.
  Title
Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase.
  Journal
J Biol Chem 276:2321-4 (2001)
DOI:10.1074/jbc.C000616200
Other DBs
ExplorEnz - The Enzyme Database: 1.8.3.5
IUBMB Enzyme Nomenclature: 1.8.3.5
ExPASy - ENZYME nomenclature database: 1.8.3.5
BRENDA, the Enzyme Database: 1.8.3.5
CAS: 196717-99-4
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