KEGG   ENZYME: 1.8.98.1
Entry
EC 1.8.98.1                 Enzyme                                 

Name
dihydromethanophenazine:CoB-CoM heterodisulfide reductase;
hdrDE (gene names);
CoB---CoM heterodisulfide reductase (ambiguous);
heterodisulfide reductase (ambiguous);
coenzyme B:coenzyme M:methanophenazine oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With other, known, physiological acceptors
Sysname
CoB:CoM:methanophenazine oxidoreductase
Reaction(IUBMB)
CoB + CoM + methanophenazine = CoM-S-S-CoB + dihydromethanophenazine [RN:R04540]
Reaction(KEGG)
R04540
Substrate
CoB [CPD:C04628];
CoM [CPD:C03576];
methanophenazine [CPD:C11903]
Product
CoM-S-S-CoB [CPD:C04832];
dihydromethanophenazine [CPD:C11904]
Comment
This enzyme, found in methanogenic archaea that belong to the Methanosarcinales order, regenerates CoM and CoB after the action of EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. It is a membrane-bound enzyme that contains (per heterodimeric unit) two distinct b-type hemes and two [4Fe-4S] clusters. cf. EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase, EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase and EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase.
History
EC 1.8.98.1 created 2003, modified 2017
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08264  heterodisulfide reductase subunit D
K08265  heterodisulfide reductase subunit E
Genes
DAL: Dalk_1625 Dalk_4040 Dalk_4954
DTO: TOL2_C11570 TOL2_C26590
DTI: Desti_0745 Desti_5348 Desti_5359
SFU: Sfum_1176 Sfum_1801
DBR: Deba_2985
BJU: BJ6T_87480
BJP: RN69_42255
RHZ: RHPLAN_09760
BFD: NCTC4823_02385(fadF_3)
CLS: CXIVA_16140(GlpC)
STED: SPTER_30050(fadF)
AFO: Afer_2003
MBAS: ALGA_3860
CPI: Cpin_5887
FLN: FLA_3557
SGN: SGRA_1094
PHE: Phep_0746
SDJ: NCTC13534_04277(glpC)
STHA: NCTC11429_03180(glpC)
MUC: MuYL_1450
CHU: CHU_0123(ykgE)
DFE: Dfer_4016
SLI: Slin_5544
LBY: Lbys_2731
FAE: FAES_0224
HSW: Hsw_4302
FLM: MY04_1429
GFO: GFO_1636
GFL: GRFL_3307
FIN: KQS_07140
COC: Coch_0507
ZPR: ZPR_2739
MARM: YQ22_14830
CBAL: M667_12255
CBAT: M666_12175
DDO: I597_2441(glpC_2)
MLT: VC82_2479
NDO: DDD_3081
MPW: MPR_1407
WIN: WPG_3012
TMAR: MARIT_1250
SPON: HME9304_02805(glcD)
KAN: IMCC3317_06930(lutA)
MARF: CJ739_3272
MESQ: C7H62_2405
FBA: FIC_00133
FBU: UJ101_02687(glcD)
RAI: RA0C_1249
RAR: RIA_1247
RAG: B739_0901
RAE: G148_0626
RAT: M949_1368
EAO: BD94_3883
ELB: VO54_02815(lutA_1)
CHZ: CHSO_4739
METC: MTCT_0104
METE: tca_00123(glpC)
MOL: YLM1_0621
METH: MBMB1_0927
FPL: Ferp_0942
GAC: GACE_1903
GAH: GAH_00753
MEAR: Mpt1_c14100(hdrD2)
MARC: AR505_0040
ABI: Aboo_0983
MAC: MA_0687(hdrE) MA_0688(hdrD)
MMA: MM_1843(hdrE) MM_1844(hdrD)
MCJ: MCON_3441(hdrE) MCON_3442(hdrD)
IHO: Igni_1369
TPE: Tpen_0594
BARC: AOA65_0539(hdrD_2) AOA65_0555(hdrD_3) AOA65_1721(hdrD_4) AOA65_2237(hdrD_5)
BARB: AOA66_1745(hdrD_3) AOA66_1757(hdrD_4)
PSYT: DSAG12_01123(hdrD_1) DSAG12_02413(hdrD_2) DSAG12_02953(hdrD_3) DSAG12_03453(hdrD_6)
 » show all
Reference
1  [PMID:2121478]
  Authors
Hedderich R, Berkessel A, Thauer RK
  Title
Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 193:255-61 (1990)
DOI:10.1111/j.1432-1033.1990.tb19331.x
Reference
2  [PMID:9555882]
  Authors
Abken HJ, Tietze M, Brodersen J, Baumer S, Beifuss U, Deppenmeier U.
  Title
Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1.
  Journal
J Bacteriol 180:2027-32 (1998)
DOI:10.1128/JB.180.8.2027-2032.1998
Reference
3  [PMID:9665708]
  Authors
Simianu M, Murakami E, Brewer JM, Ragsdale SW.
  Title
Purification and properties of the heme- and iron-sulfur-containing heterodisulfide reductase from Methanosarcina thermophila.
  Journal
Biochemistry 37:10027-39 (1998)
DOI:10.1021/bi9726483
Reference
4  [PMID:11034998]
  Authors
Murakami E, Deppenmeier U, Ragsdale SW.
  Title
Characterization of the intramolecular electron transfer pathway from 2-hydroxyphenazine to the heterodisulfide reductase from Methanosarcina thermophila.
  Journal
J Biol Chem 276:2432-9 (2001)
DOI:10.1074/jbc.M004809200
Other DBs
ExplorEnz - The Enzyme Database: 1.8.98.1
IUBMB Enzyme Nomenclature: 1.8.98.1
ExPASy - ENZYME nomenclature database: 1.8.98.1
BRENDA, the Enzyme Database: 1.8.98.1
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