KEGG   ENZYME: 1.8.98.6
Entry
EC 1.8.98.6                 Enzyme                                 

Name
formate:CoB-CoM heterodisulfide,ferredoxin reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With other, known, physiological acceptors
Sysname
coenzyme B,coenzyme M,ferredoxin:formate oxidoreductase
Reaction(IUBMB)
2 CO2 + 2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+ = 2 formate + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB [RN:R11944]
Reaction(KEGG)
R11944
Substrate
CO2 [CPD:C00011];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
CoB [CPD:C04628];
CoM [CPD:C03576];
H+ [CPD:C00080]
Product
formate [CPD:C00058];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139];
CoM-S-S-CoB [CPD:C04832]
Comment
The enzyme is found in formate-oxidizing CO2-reducing methanogenic archaea such as Methanococcus maripaludis. It consists of a cytoplasmic complex of HdrABC reductase and formate dehydrogenase. Electron pairs donated by formate dehydrogenase are transferred to the HdrA subunit of the reductase, where they are bifurcated, reducing both ferredoxin and CoB-CoM heterodisulfide. cf. EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase, EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.
History
EC 1.8.98.6 created 2017
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00125  formate dehydrogenase (coenzyme F420) beta subunit
K03388  heterodisulfide reductase subunit A2
K03389  heterodisulfide reductase subunit B2
K03390  heterodisulfide reductase subunit C2
K14127  F420-non-reducing hydrogenase iron-sulfur subunit
K22516  formate dehydrogenase (coenzyme F420) alpha subunit
Genes
VNA: PN96_21155
VEJ: VEJY3_20411
PGB: H744_1c0419
PGH: FH974_23235(fdhF)
PSH: Psest_3905
PSTU: UIB01_19765
PCH: EY04_14750
PSED: DM292_16890
GNI: GNIT_2862
TIG: THII_2279 THII_2280
TNI: TVNIR_3244(hdrB_[H]) TVNIR_3245(hdlC_[H]) TVNIR_3247(hdrA_[H]) TVNIR_3248(hdlB_[H]) TVNIR_3249
ENM: EBS_2144(hdrC) EBS_2145(hdrB)
CBX: Cenrod_2147(hdrA) Cenrod_2148(mvhD)
SHD: SUTH_02768(hdrC) SUTH_02769(hdrB)
SDR: SCD_n01881(hdrB) SCD_n01882(hdrC)
ABRE: pbN1_04290(bzdV)
CCO: CCC13826_0200(fdhH)
CCOC: CCON33237_0536(fdhH)
CGRA: CGRAC_1361(fdhH)
CPIN: CPIN18020_0262(fdhH)
CGEO: CGEO_1649(fdhH)
CMUC: CMCT_1635(fdhH)
CSHO: CSHOW_0456(fdhH)
AHS: AHALO_1025(fdhH)
AMAR: AMRN_1963(fdhH)
ACAA: ACAN_2017(fdhH)
SULJ: SJPD1_1032
GSU: GSU0088(hdrD) GSU0089(hdrG) GSU0090(hdrA) GSU0091(hdrB) GSU0092(hdrC)
GSK: KN400_0063(hdrD) KN400_0064(hdrG) KN400_0065(hdrA) KN400_0066(hdrB) KN400_0067(hdrC)
GME: Gmet_2083(bamF) Gmet_2084(bamE) Gmet_3424(hdrC) Gmet_3425(hdrB) Gmet_3426(hdrA) Gmet_3427(hdrG) Gmet_3428(hdrD)
GBM: Gbem_0028(hdrD) Gbem_0029(hdrG) Gbem_0030(hdrA) Gbem_0031(hdrB) Gbem_0032(hdrC) Gbem_1447(bamE) Gbem_1448(bamF)
GEO: Geob_0149 Geob_0215(bamE-1) Geob_0216(bamF-1) Geob_0231(bamE-2) Geob_0232(bamF-2) Geob_3720(hdrD) Geob_3721(hdrG) Geob_3723(hdrA) Geob_3724(hdrB) Geob_3725(hdrC)
PCA: Pcar_2701
DVU: DVU_2402(hdrA) DVU_2403(hdrB) DVU_2404(hdrC)
DGG: DGI_1048(hdrC) DGI_1049(hdrB) DGI_1050(hdrA) DGI_1051(floxD) DGI_1052(floxC)
DTR: RSDT_0565(hdrC) RSDT_0566(hdrB) RSDT_0567(hdrA)
DPI: BN4_11858(hdrC) BN4_11859(hdrB) BN4_11860(hdrA) BN4_11861(mvhD) BN4_11862
DML: Dmul_02420 Dmul_02770(hdrA1) Dmul_24490(bamF) Dmul_24500(bamE) Dmul_28840(mvhD2) Dmul_28860(hdrA2) Dmul_28870(hdrB) Dmul_28880(hdrC)
DAT: HRM2_11710(hdrA1) HRM2_11720(mvhD2) HRM2_11850(hdrA2) HRM2_11860(mvhD3) HRM2_11880(fdhA3) HRM2_14330(hdrA3) HRM2_14340(hdrA3') HRM2_14350(mvhD4) HRM2_14370(fdhA4) HRM2_22080(fdhB5) HRM2_22090(mvhD5) HRM2_22100(hdrL1) HRM2_22720(hdrL2) HRM2_22730(mvhD6) HRM2_22740(fdhB6) HRM2_22750(hdrA4) HRM2_22760(hdrD2) HRM2_22770(hdrD2') HRM2_30780 HRM2_30880(mvhD7) HRM2_30890(hdrL3)
ADE: Adeh_4164
ATX: GCD22_01577(hdrB1) GCD22_02661(hdrB1) GCD22_03145(hdrB) GCD22_03146(hdlC) GCD22_03148(hdrA) GCD22_03149(hdrB1) GCD22_03150 GCD22_03192(hdrB1) GCD22_03279(hdrA)
EFS: EFS1_1216
ENE: ENT_08450
CSQ: CSCA_0253
DSY: DSY1990
DHD: Dhaf_3153
PTH: PTH_1407(RnfC) PTH_1409(FrhD) PTH_1410(HdrA) PTH_1412(HdrB) PTH_1413(GlpC)
SFI: SFUL_466
DFO: Dform_00893(hdrA) Dform_00920(hdrA) Dform_00940(mvhD|vhcD) Dform_00941(hdrA) Dform_00942(hdrB) Dform_00943(hdrC)
CTE: CT1245 CT1246(hdrA-2) CT1247(mvhD)
AAE: aq_391 aq_395(hdrA) aq_398(hdrC) aq_400(hdrB)
HTH: HTH_1878(hdrB1) HTH_1879(hdrC1) HTH_1881(hdrA) HTH_1882(hdrB2) HTH_1883(hdrC2)
MMP: MMP0138(fdhA) MMP0139(fdhB) MMP0821(vhcD) MMP0825(hdrA) MMP1053(hdrB2) MMP1054(hdrC2) MMP1154(hdrC1) MMP1155(hdrB1) MMP1297(fdhB) MMP1298(fdhA) MMP1696(vhuD) MMP1697(hdrA)
MMAK: MMKA1_01430(fdhA) MMKA1_01440(fdhB) MMKA1_09060(vhcD) MMKA1_09100(hdrA) MMKA1_12180(hdrB) MMKA1_12190(hdrC) MMKA1_13320(hdrC) MMKA1_13330(hdrB) MMKA1_15220(fdhB) MMKA1_15230(fdhA) MMKA1_19300(vhuD) MMKA1_19310(hdrA)
MMAO: MMOS7_01690(fdhA) MMOS7_01700(fdhB) MMOS7_08840(vhcD) MMOS7_08880(hdrA) MMOS7_11480(hdrB) MMOS7_11490(hdrC) MMOS7_12620(hdrC) MMOS7_12630(hdrB) MMOS7_14040(fdhB) MMOS7_14050(fdhA) MMOS7_18110(vhuD) MMOS7_18120(hdrA)
MST: Msp_0314(mvhD1) Msp_0638(mvhD2) Msp_0639(fdhB) Msp_0640(fdhA) Msp_1013(hdrB1) Msp_1014(hdrC1) Msp_1476(hdrA1)
MRU: mru_0117(hdrA) mru_0333(fdhA1) mru_0334(fdhB1) mru_0816(hdrC) mru_0817(hdrB1) mru_1908(mvhD1) mru_2074(fdhA2) mru_2075(fdhB2) mru_2076(mvhD2)
MEB: Abm4_0131(fdhA) Abm4_0132(fdhB) Abm4_0853(mvhD2) Abm4_0854(fdhB2) Abm4_0855(fdhA2) Abm4_1308(hdrB2) Abm4_1309(hdrC2) Abm4_1512(mvhD) Abm4_1691(hdrA2)
MMIL: sm9_1348(flpD) sm9_1349(flpB) sm9_1350(flpA) sm9_1716(hdrB3) sm9_1717(hdrC2) sm9_2013(mvhD) sm9_2182(fdhB) sm9_2183(fdhA) sm9_2251(hdrA2)
METH: MBMB1_0103(fdhB) MBMB1_0104(fdhA) MBMB1_1274(hdrB) MBMB1_1275 MBMB1_1663(mvhD) MBMB1_1958(hdrA)
MFC: BRM9_0167(fdhB) BRM9_0168(fdhA) BRM9_0490(hdrB1) BRM9_0491(hdrC1) BRM9_0915(mvhD) BRM9_2298(hdrA2)
MCUB: MCBB_1489(hdrB3) MCBB_1490(hdrC3) MCBB_1968(mvhD) MCBB_2028(fdhA) MCBB_2029(fdhB1) MCBB_2030(vhcD) MCBB_2031(fdhB3) MCBB_2243(hdrA3)
MKA: MK0249(hdrA_1) MK0265(hdrA_2) MK0268(flpD_1) MK0321 MK0322 MK0572(hdrB) MK0573(hdrC) MK0627(flpD_2)
PYN: PNA2_1925
PYS: Py04_1234
TKO: TK2076
TGA: TGAM_0065(mhy2A) TGAM_0631(fdhA)
TSI: TSIB_0067
THA: TAM4_610
THS: TES1_1496
TEU: TEU_00760
PPAC: PAP_03230
MAC: MA_2868(hdrA) MA_4236(hdrC) MA_4237(hdrB)
MBU: Mbur_0552(hdrA) Mbur_1516(hdrC) Mbur_1517(hdrB)
MCJ: MCON_2237(fdhA) MCON_3279(hdrA) MCON_3282(hdrC) MCON_3283(hdrB)
MBG: BN140_0752(hdrA1) BN140_0841(fdhB) BN140_0842(fdhA) BN140_1327(fdhA1) BN140_1328(fdhB1) BN140_1329(fdhA2) BN140_1330(fdhB2) BN140_1726(hdrC) BN140_1727(hdrB) BN140_1728(hdrA3) BN140_1729(MvhD) BN140_2197(fdhB3) BN140_2198(fdhA3)
MEMA: MMAB1_0971(hdrA) MMAB1_1105(fdhB) MMAB1_1106(fdhA) MMAB1_1689(fdhA) MMAB1_1690(fdhB) MMAB1_2221(hdrC) MMAB1_2222(hdrB) MMAB1_2223(hdrA) MMAB1_2224(vhcD) MMAB1_2913(fdhB) MMAB1_2914(fdhA)
MPD: MCP_1569(fdhB-1) MCP_1570(fdhA-1) MCP_1575(mvhD-1) MCP_1576(hdrA-1) MCP_1577(hdrB-1) MCP_1578(hdrC-1) MCP_2406(fdhB-2) MCP_2407(fdhA-2) MCP_2767(mvhD-2) MCP_2768(hdrA-2) MCP_2769(hdrB-3) MCP_2770(hdrC-3)
MEZ: Mtc_2124(fdhB) Mtc_2125(fdhA) Mtc_2472(mvhD-2) Mtc_2473(hdrA-2) Mtc_2474(hdrB-2) Mtc_2475(hdrC-2)
RCI: RCIX1628(fdhA-1) RCIX1630(fdhB-1) RCIX2372(fdhB-2) RCIX2373(fdhA-2) RCIX2376(fdhB-3) RCIX2378(fdhA-3) RCIX594(hdrC-2) RCIX595(hdrB-2) RCIX596(hdrA-2) RCIX597(mvhD-1) RRC251(fdhA-4) RRC252(fdhB-4) RRC256(hdrC-3) RRC257(hdrB-3) RRC258(hdrA-3) RRC259(mvhD-2)
HHB: Hhub_2705(fdhA)
HALH: HTSR_1736(fdhA) HTSR_1740(fdhA2)
HHSR: HSR6_1802(fdoG2) HSR6_1806(fdoG3)
HHI: HAH_5041(fdhA)
NMO: Nmlp_2714(fdhA)
HLA: Hlac_1238
HALQ: Hrr1229_013155(fdhF)
HSS: J7656_05930(fdhF) J7656_13980(fdhF)
HALU: HUG12_20610(fdhF)
HDF: AArcSl_0465(fdoG) AArcSl_1489(fdoG2) AArcSl_1855(hdrA)
HTU: Htur_0685
HALY: HYG82_00570(fdhF)
HSAL: JMJ58_05665(fdhF)
TAC: Ta0045
TVO: TVG0003442(TVG0003442)
FAI: FAD_1471
MEAR: Mpt1_c02960(hdrC1) Mpt1_c02970(hdrB1) Mpt1_c08830(hdrB2) Mpt1_c08840(hdrC2) Mpt1_c10570(vhcD) Mpt1_c10580(hdrA)
IHO: Igni_1101
IIS: EYM_07315
SSO: SSO1127(hdrC-1) SSO1129(hdrB-1) SSO1131(hdrA) SSO1134(hdrC-2) SSO1135(hdrB-2)
TPE: Tpen_0190
BARC: AOA65_0030(hdrC_1) AOA65_1112(hdrA_1) AOA65_1400(hdrC_2) AOA65_1401(hdrB_2) AOA65_1402(hdrA_3) AOA65_1715(mvhD_1) AOA65_1718(mvhD_2) AOA65_1719(hdlA_2) AOA65_1720(sudA_4) AOA65_1887(hdrB_3) AOA65_1888(hdrC_3) AOA65_1889(vhcD) AOA65_1993(hdrB_4) AOA65_1994(hdrC_4) AOA65_1995(hdrA_4)
BARB: AOA66_0155(hdrA_1) AOA66_1507(hdrB_1) AOA66_1508(hdrC_1) AOA66_1509(vhcD) AOA66_1510(hdrA_2) AOA66_1511(mvhD) AOA66_1512(hdlA_2) AOA66_1513(hdrA_3) AOA66_1526(hdrA_4) AOA66_1731(hdrB_2) AOA66_1732(hdrC_2)
PSYT: DSAG12_01135(mvhD_1) DSAG12_01136(hdrA_1) DSAG12_01137(hdrB_1) DSAG12_01138(hdrC_1) DSAG12_01145(hdrC_2) DSAG12_01146(hdrB_2) DSAG12_01147(hdrA_2) DSAG12_01148(mvhD_2) DSAG12_01161(hdrB_3) DSAG12_01162(hdrC_3) DSAG12_02784(fdhB_1) DSAG12_02804(mvhD_4) DSAG12_02805(hdrA_4) DSAG12_02806(hdrC_4) DSAG12_02807(hdrB_4) DSAG12_03218(hdrC_5) DSAG12_03220(hdrA_5) DSAG12_03223(hdrB_5) DSAG12_03719(fdhB_2) DSAG12_03720(vhcD) DSAG12_03721(hdrA_6) DSAG12_03722(mvhD_5) DSAG12_03723(hdlA_4) DSAG12_03724(hdrA_7) DSAG12_03725(hdrB_6) DSAG12_03726(hdrC_6) DSAG12_03952(hdrB_7) DSAG12_03953(hdrC_7)
 » show all
Reference
1  [PMID:20534465]
  Authors
Costa KC, Wong PM, Wang T, Lie TJ, Dodsworth JA, Swanson I, Burn JA, Hackett M, Leigh JA
  Title
Protein complexing in a methanogen suggests electron bifurcation and electron delivery from formate to heterodisulfide reductase.
  Journal
Proc Natl Acad Sci U S A 107:11050-5 (2010)
DOI:10.1073/pnas.1003653107
Reference
2  [PMID:24039260]
  Authors
Costa KC, Lie TJ, Xia Q, Leigh JA
  Title
VhuD facilitates electron flow from H2 or formate to heterodisulfide reductase in Methanococcus maripaludis.
  Journal
J Bacteriol 195:5160-5 (2013)
DOI:10.1128/JB.00895-13
Other DBs
ExplorEnz - The Enzyme Database: 1.8.98.6
IUBMB Enzyme Nomenclature: 1.8.98.6
ExPASy - ENZYME nomenclature database: 1.8.98.6
BRENDA, the Enzyme Database: 1.8.98.6
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