Entry |
|
Name |
sterigmatocystin 8-O-methyltransferase;
sterigmatocystin methyltransferase;
O-methyltransferase II;
sterigmatocystin 7-O-methyltransferase (incorrect);
S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase (incorrect);
OmtA
|
Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
|
Sysname |
S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase
|
Reaction(IUBMB) |
(1) S-adenosyl-L-methionine + sterigmatocystin = S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin [RN: R03111];
(2) S-adenosyl-L-methionine + dihydrosterigmatocystin = S-adenosyl-L-homocysteine + 8-O-methyldihydrosterigmatocystin [RN: R10307]
|
Reaction(KEGG) |
|
Substrate |
S-adenosyl-L-methionine [CPD: C00019];
sterigmatocystin [CPD: C00961];
dihydrosterigmatocystin [CPD: C20445]
|
Product |
S-adenosyl-L-homocysteine [CPD: C00021];
8-O-methylsterigmatocystin [CPD: C03686];
8-O-methyldihydrosterigmatocystin [CPD: C03944]
|
Comment |
Dihydrosterigmatocystin can also act as acceptor. Involved in the biosynthesis of aflatoxins in fungi.
|
History |
EC 2.1.1.110 created 1992, modified 2005, modified 2013
|
Pathway |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K17650 | sterigmatocystin 8-O-methyltransferase |
|
Genes |
|
Reference |
|
Authors |
Bhatnagar D, McCormick SP, Lee LS, Hill RA. |
Title |
Identification of O-methylsterigmatocystin as an aflatoxin B1 and G1 precursor in Aspergillus parasiticus. |
Journal |
|
Reference |
|
Authors |
Yabe K, Ando Y, Hashimoto J, Hamasaki T. |
Title |
Two distinct O-methyltransferases in aflatoxin biosynthesis. |
Journal |
|
Reference |
|
Authors |
Yu J, Cary JW, Bhatnagar D, Cleveland TE, Keller NP, Chu FS |
Title |
Cloning and characterization of a cDNA from Aspergillus parasiticus encoding an O-methyltransferase involved in aflatoxin biosynthesis. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Lee LW, Chiou CH, Linz JE |
Title |
Function of native OmtA in vivo and expression and distribution of this protein in colonies of Aspergillus parasiticus. |
Journal |
|
Other DBs |
ExPASy - ENZYME nomenclature database: | 2.1.1.110 |
|
LinkDB |
|