| Entry |
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| Name |
sterigmatocystin 8-O-methyltransferase;
sterigmatocystin methyltransferase;
O-methyltransferase II;
sterigmatocystin 7-O-methyltransferase (incorrect);
S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase (incorrect);
OmtA
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase
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| Reaction(IUBMB) |
(1) S-adenosyl-L-methionine + sterigmatocystin = S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin [RN: R03111];
(2) S-adenosyl-L-methionine + dihydrosterigmatocystin = S-adenosyl-L-homocysteine + 8-O-methyldihydrosterigmatocystin [RN: R10307]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
sterigmatocystin [CPD: C00961];
dihydrosterigmatocystin [CPD: C20445]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
8-O-methylsterigmatocystin [CPD: C03686];
8-O-methyldihydrosterigmatocystin [CPD: C03944]
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| Comment |
Dihydrosterigmatocystin can also act as acceptor. Involved in the biosynthesis of aflatoxins in fungi.
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| History |
EC 2.1.1.110 created 1992, modified 2005, modified 2013
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K17650 | sterigmatocystin 8-O-methyltransferase |
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| Genes |
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| Reference |
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| Authors |
Bhatnagar D, McCormick SP, Lee LS, Hill RA. |
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| Title |
Identification of O-methylsterigmatocystin as an aflatoxin B1 and G1 precursor in Aspergillus parasiticus. |
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| Journal |
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| Reference |
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| Authors |
Yabe K, Ando Y, Hashimoto J, Hamasaki T. |
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| Title |
Two distinct O-methyltransferases in aflatoxin biosynthesis. |
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| Journal |
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| Reference |
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| Authors |
Yu J, Cary JW, Bhatnagar D, Cleveland TE, Keller NP, Chu FS |
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| Title |
Cloning and characterization of a cDNA from Aspergillus parasiticus encoding an O-methyltransferase involved in aflatoxin biosynthesis. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Lee LW, Chiou CH, Linz JE |
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| Title |
Function of native OmtA in vivo and expression and distribution of this protein in colonies of Aspergillus parasiticus. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.110 |
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| LinkDB |
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